Pre- and post-synaptic sympathetic function in human hibernating myocardium

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 34, Issue 12, 2007, Pages 1973-1980

  John, Anna S ^a   Mongillo, Marco ^b   Depre, Christophe ^c   Khan, Muhammad T ^b   Rimoldi, Ornella E ^a,b,d   Pepper, John R ^a   Dreyfus, Gilles D ^a   Pennell, Dudley J ^a   Camici, Paolo G ^a,b  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^d NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Beta adrenergic receptors; Coronary disease; Heart failure; Hibernation; Imaging

Indexed keywords

4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; 4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE C 11; BETA ADRENERGIC RECEPTOR; METAHYDROXYEPHEDRINE C 11; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DATA ANALYSIS; DIAGNOSTIC IMAGING; FEMALE; HEART DISEASE; HEART FAILURE; HEART INFARCTION; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART SURGERY; HUMAN; MALE; MYOCARDIAL HIBERNATION; NORADRENALIN UPTAKE; NUCLEAR MAGNETIC RESONANCE IMAGING; PERIPHERAL NERVOUS SYSTEM; POSITRON EMISSION TOMOGRAPHY; POSTSYNAPTIC POTENTIAL; PRESYNAPTIC POTENTIAL; STATISTICAL SIGNIFICANCE; SWINE; SYMPATHETIC FUNCTION; SYMPATHETIC TONE;

AGED; AGED, 80 AND OVER; CORONARY ARTERY DISEASE; HUMANS; MIDDLE AGED; MYOCARDIAL STUNNING; NOREPINEPHRINE; RECEPTORS, ADRENERGIC, BETA; SYMPATHETIC NERVOUS SYSTEM; SYNAPSES;

EID: 36749082801     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-007-0507-1     Document Type: Article

References (31)

1. Cowie MR, Mosterd A, Wood DA, Deckers JW, Poole-Wilson PA, Sutton GC, et al. The epidemiology of heart failure. Eur Heart J 1997;18:208-25.
2. Rahimtoola SH. A perspective on the three large multicenter randomized clinical trials of coronary bypass surgery for chronic stable angina. Circulation 1985;72:V123-35.
3. Wijns W, Vatner SF, Camici PG. Hibernating myocardium. N Engl J Med 1998;339:173-81.
4. Eisenhofer G, Friberg P, Rundqvist B, Quyyumi AA, Lambert G, Kaye DM, et al. Cardiac sympathetic nerve function in congestive heart failure. Circulation 1996;93:1667-76.
5. Spyrou N, Rosen SD, Fath-Ordoubadi F, Jagathesan R, Foale R, Kooner JS, et al. Myocardial beta-adrenoceptor density one month after acute myocardial infarction predicts left ventricular volumes at six months. J Am Coll Cardiol 2002;40:1216-24.
6. Luisi AJ, Jr, Fallavollita JA, Suzuki G, Canty JM Jr. Spatial inhomogeneity of sympathetic nerve function in hibernating myocardium. Circulation 2002;106:779-81.
7. 11C-hydroxyephedrine retention in hibernating myocardium: chronic inhomogeneity of sympathetic innervation in the absence of infarction. J Nucl Med 2005;46:1368-74.
8. Shan K, Bick RJ, Poindexter BJ, Nagueh SF, Shimoni S, Verani MS, et al. Altered adrenergic receptor density in myocardial hibernation in humans: a possible mechanism of depressed myocardial function. Circulation 2000;102:2599-606.
9. Kim RJ, Fieno DS, Parrish TB, Harris K, Chen EL, Simonetti O, et al. Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. Circulation 1999;100:1992-2002.
10. Kim RJ, Shah DJ, Judd RM. How we perform delayed enhancement imaging. J Cardiovasc Magn Reson 2003;5:505-14.
11. 99mTc-tetrofosmin, and dobutamine magnetic resonance imaging for identifying hibernating myocardium. Circulation 1998;98:1869-74.
12. Schafers M, Dutka D, Rhodes CG, Lammertsma AA, Hermansen F, Schober O, et al. Myocardial presynaptic and postsynaptic autonomic dysfunction in hypertrophic cardiomyopathy. Circ Res 1998;82:57-62.
13. 11C]CGP 12177) as a preferred radioligand for beta-adrenergic receptors. Int J Rad Appl Instrum [A] 1991;42:621-8.
14. Lefroy DC, de Silva R, Choudhury L, Uren NG, Crake T, Rhodes CG, et al. Diffuse reduction of myocardial beta-adrenoceptors in hypertrophic cardiomyopathy: a study with positron emission tomography. J Am Coll Cardiol 1993;22:1653-60.
15. Delforge J, Syrota A, Lancon JP, Nakajima K, Loc'h C, Janier M, et al. Cardiac beta-adrenergic receptor density measured in vivo using PET, CGP 12177, and a new graphical method. J Nucl Med 1991;32:739-48.
16. Lorenzoni R, Pagano D, Boyd H, Camici PG. A report system for PET assessment of myocardial viability. Nucl Med Commun 1999;20:895-9.
17. Bax JJ, Poldermans D, Elhendy A, Cornel JH, Boersma E, Rambaldi R, et al. Improvement of left ventricular ejection fraction, heart failure symptoms and prognosis after revascularization in patients with chronic coronary artery disease and viable myocardium detected by dobutamine stress echocardiography. J Am Coll Cardiol 1999;34:163-9.
18. Fath-Ordoubadi F, Beatt KJ, Spyrou N, Camici PG. Efficacy of coronary angioplasty for the treatment of hibernating myocardium. Heart. 1999;82:210-6.
19. Pagano D, Camici PG, Bonser RS. Revascularisation for chronic heart failure: a valid option? Eur J Heart Fail 1999;1:269-73.
20. Pagano D, Fath-Ordoubadi F, Beatt KJ, Townend JN, Bonser RS, Camici PG. Effects of coronary revascularisation on myocardial blood flow and coronary vasodilator reserve in hibernating myocardium. Heart. 2001;85:208-12.
21. Selvanayagam JB, Petersen SE, Francis JM, Robson MD, Kardos A, Neubauer S, et al. Effects of off-pump versus on-pump coronary surgery on reversible and irreversible myocardial injury: a randomized trial using cardiovascular magnetic resonance imaging and biochemical markers. Circulation 2004;109:345-50.
22. Porto I, Selvanayagam JB, Van Gaal WJ, Prati F, Cheng A, Channon K, et al. Plaque volume and occurrence and location of periprocedural myocardial necrosis after percutaneous coronary intervention: insights from delayed-enhancement magnetic resonance imaging, thrombolysis in myocardial infarction myocardial perfusion grade analysis, and intravascular ultrasound. Circulation 2006;114:662-9.
23. Unger T, Li J. The role of the renin-angiotensin-aldosterone system in heart failure. J Renin Angiotensin Aldosterone Syst 2004;5 Suppl 1:S7-10.
24. Ungerer M, Bohm M, Elce JS, Erdmann E, Lohse MJ. Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart. Circulation 1993;87:454-63.
25. Bristow MR, Ginsburg R, Minobe W, Cubicciotti RS, Sageman WS, Lurie K, et al. Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts. N Engl J Med 1982;307:205-11.
26. 11C CGP-12177 to assess beta-adrenergic receptor concentration in idiopathic dilated cardiomyopathy. Circulation 1993;87:1169-78.
27. Choudhury L, Rosen SD, Lefroy DC, Nihoyannopoulos P, Oakley CM, Camici PG. Myocardial beta adrenoceptor density in primary and secondary left ventricular hypertrophy. Eur Heart J 1996;17:1703-9.
28. Schwaiger M, Kalff V, Rosenspire K, Haka MS, Molina E, Hutchins GD, et al. Noninvasive evaluation of sympathetic nervous system in human heart by positron emission tomography. Circulation 1990;82:457-64.
29. Mardon K, Montagne O, Elbaz N, Malek Z, Syrota A, Dubois-Rande JL, et al. Uptake-1 carrier downregulates in parallel with the beta-adrenergic receptor desensitization in rat hearts chronically exposed to high levels of circulating norepinephrine: implications for cardiac neuroimaging in human cardiomyopathies. J Nucl Med 2003;44:1459-66.
30. Bristow MR, Minobe W, Rasmussen R, Larrabee P, Skerl L, Klein JW, et al. Beta-adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms. J Clin Invest 1992;89:803-15.
31. Leineweber K, Wangemann T, Giessler C, Bruck H, Dhein S, Kostelka M, et al. Age-dependent changes of cardiac neuronal noradrenaline reuptake transporter (uptake1) in the human heart. J Am Coll Cardiol 2002;40:1459.