Expression profile of total VEGF, VEGF splice variants and VEGF receptors in the myocardium and arterial vasculature of diabetic and non-diabetic patients with coronary artery disease

Clinical Biochemistry

Volumn 41, Issue 1-2, 2008, Pages 82-87

  Zygalaki, Eleni ^a   Kaklamanis, Loukas ^b   Nikolaou, Nikolaos I ^b   Kyrzopoulos, Stamatis ^b   Houri, Mazen ^b   Kyriakides, Zenon ^b   Lianidou, Evi S ^a   Kremastinos, Dimitrios Th ^b  

^a UNIVERSITY OF ATHENS   (Greece)

^b ONASSIS CARDIAC SURGERY CENTER   (Greece)

Author keywords

Diabetes; Left internal mammary artery; Real time RT PCR; Right atrium; VEGF; VEGF receptors; VEGF splice variants

Indexed keywords

MESSENGER RNA; UNCLASSIFIED DRUG; VASCULOTROPIN 121; VASCULOTROPIN 145; VASCULOTROPIN 148; VASCULOTROPIN 165; VASCULOTROPIN 183; VASCULOTROPIN 189; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY DISEASE; DIABETES MELLITUS; FEMALE; GENE EXPRESSION; GENETIC HETEROGENEITY; HEART RIGHT ATRIUM; HUMAN; INTERNAL MAMMARY ARTERY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; VASCULARIZATION;

AGED; ALTERNATIVE SPLICING; CORONARY ARTERY DISEASE; CORONARY VESSELS; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; ENDOTHELIUM, VASCULAR; FEMALE; GENE EXPRESSION PROFILING; HEART ATRIA; HUMANS; MALE; MAMMARY ARTERIES; MIDDLE AGED; MYOCARDIUM; PROTEIN ISOFORMS; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 36749022850     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2007.09.005     Document Type: Article

References (32)

1. Ferrara N. The biology of vascular endothelial growth factor. Endocr Rev 18 (1997) 4-25
2. Ferrara N., Gerber H.P., and LeCouter J. The biology of VEGF and its receptors. Nat Med 9 (2003) 669-676
3. Ruhrberg C. Growing and shaping the vascular tree: multiple roles for VEGF. BioEssays 25 (2003) 1052-1060
4. Toi M., Matsumoto T., and Bando H. Vascular endothelial growth factor: its prognostic, predictive, and therapeutic implications. Lancet Oncol 2 (2001) 667-673
5. Ladomery M.R., Harper S.J., and Bates D.O. Alternative splicing in angiogenesis: the vascular endothelial growth factor paradigm. Cancer Lett 249 (2007) 133-142
6. Tisher E., Mitchell R., Hartmann T., et al. The human gene for vascular endothelial growth factor. J Biol Chem 266 (1991) 11947-11954
7. 148 mRNA, a novel truncated splice variant. Clin Sci 97 (1999) 303-312
8. Lei J., Jiang A., and Pei D. Identification and characterization of a new splicing variant of vascular endothelial growth factor: VEGF 183. Biochim Biophys Acta 14443 (1998) 400-406
9. Poltorak Z., Cohen T., Sivan R., et al. VEGF 145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix. J Biol Chem 272 (1997) 7151-7158
10. Stimpfl M., Tong D., Fasching B., et al. Vascular endothelial growth factor splice variants and their prognostic value in breast and ovarian cancer. Clin Cancer Res 8 (2002) 2253-2259
11. Zygalaki E., Stathopoulou A., Kroupis C., et al. Real time RT-PCR quantification of vascular endothelial growth factor (VEGF) splice variants. Clin Chem 51 (2005) 1518-1520
12. Houck K.A., Ferrara N., Winer J., Cachianes G., Li B., and Leung D.W. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 5 (1991) 1806-1814
13. Duh E., and Aiello L.P. Vascular endothelial growth factor and diabetes. The agonist versus antagonist paradox. Diabetes 48 (1999) 1899-1905
14. Aiello L.P., Avery R.L., Arrigg P.G., et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 331 (1994) 1480-1487
15. Cooper M.E., Vranes D., Youssef S., et al. Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes. Diabetes 48 (1999) 2229-2239
16. Matsunaga T., Warltier D.C., Weihrauch D.W., Moniz M., Tessmer J., and Chilian W.M. Ischemia-induced coronary collateral growth is dependent on vascular endothelial growth factor and nitric oxide. Circulation 102 (2000) 3098-3103
17. Schultz A., Lavie L., Hochberg I., et al. Interindividual heterogeneity in the hypoxic regulation of VEGF. Significance for the development of the coronary artery collateral circulation. Circulation 100 (1999) 547-552
18. Waltenberger J., Lange J., and Kranz A. Vascular endothelial growth factor-a-induced chemotaxis of monocytes is attenuated in patients with diabetes mellitus. A potential predictor for the individual capacity to develop collaterals. Circulation 102 (2000) 185-190
19. Rivard A., Silver M., Chen D., et al. Rescue of diabetes-related impairment of angiogenesis by intramuscular gene therapy with adeno-VEGF. Am J Pathol 154 (1999) 355-363
20. Chou E., Suzuma I., Way K.J., et al. Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic states. A possible explanation for impaired collateral formation in cardiac tissue. Circulation 105 (2002) 373-379
21. Sasso F.C., Carbonara O., Persico E., et al. Increased vascular endothelial growth factor mRNA expression in the heart of streptozotocin-induced diabetic rats. Metabolism 52 (2003) 675-678
22. Sasso F.C., Torella D., Carbonara O., et al. Increased vascular endothelial growth factor expression but impaired vascular endothelial growth factor receptor signalling in the myocardium of type 2 diabetic patients with chronic coronary artery disease. J Am Coll Cardiol 46 (2005) 827-834
23. Yoon Y., Uchida S., Masuo O., et al. Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of local vascular endothelial growth factor. Circulation 111 (2005) 2073-2085
24. A receptor antagonist. EJP 542 (2006) 184-185
25. Lorusso R., Pentiricci S., Raddino R., et al. Influence of type 2 diabetes on functional and structural properties of coronary artery bypass conduits. Diabetes 52 (2003) 2814-2820
26. Zygalaki E., Tsaroucha E.G., Kaklamanis L., and Lianidou E. Quantitative real time RT-PCR study of the expression of vascular endothelial growth factor (VEGF) splice variants and VEGF receptors (VEGFR-1 and VEGFR-2) in non small cell lung cancer. Clin Chem 53 (2007) 1433-1439
27. Moniotte S., Vaerman J.L., Kockx M.M., et al. Real-time RT-PCR for the detection of beta-adrenoceptor messenger RNAs in small human endomyocardial biopsies. J Mol Cell Cardiol 33 (2001) 2121-2133
28. Chung A.W.Y., Hsiang Y.N., Matzke L.A., Mcmanus B.M., Van Breemen C., and Okon E.B. Reduced expression of vascular endothelial growth factor paralleled with the increased angiostatin expression resulting from the upregulated activities of matrix metalloproteinase-2 and -9 in human type 2 diabetic arterial vasculature. Circ Res 99 (2006) 140-148
29. Abaci A., Oguzhan A., Kahraman S., et al. Effect of diabetes mellitus on formation of coronary collateral vessels. Circulation 99 (1999) 2239-2242
30. Werner G.S., Richartz B.M., Heinke S., Ferrari M., and Figulla H.R. Impaired acute collateral recruitment as a possible mechanism for increased cardiac adverse events in patients with diabetes mellitus. Eur Heart J 24 (2003) 1134-1142
31. Carmeliet P., Ng Y.S., Nuyens D., et al. Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial isoforms VEGF164 and VEGF188. Nat Med 5 (1999) 495-502
32. NG Y.S., Rohan R., Sunday M.E., Demello D.E., and D'Amore P.A. Differential expression of VEGF isoforms in mouse during development and in the adult. Dev Dyn 220 (2001) 112-121