New routes to steroidal heterocyclic derivatives: Synthesis of biologically active pyrazolyl- and isoxazolylpregnene derivatives

Journal of Heterocyclic Chemistry

Volumn 44, Issue 1, 2007, Pages 7-11

  Abdelhamid, Abdou O ^a   Abdelhalim, Mervat M ^b   Elmegeed, Gamal A ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

10,13 DIMETHYL 17 (7 METHYL 2 PHENYL 2H PYRAZOL[3,4 D]PYRIDAZIN 2 YL) 1,2,6,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDROCYCLOPENTA[A]PHENANTHREN 3 ONE; 10,13 DIMETHYL 17 (7 PHENYLISOXAZOLO[3,4 D]PYRIDAZIN 4 YL) 1,2,6,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDROCYCLOPENTA[A]PHENANTHREN 3 ONE; 10,13 DIMETHYL 17 [7 (4 THIEN 2 YL)ISOXAZOLO[3,4 D]PYRIDAZIN 4 YL] 1,2,6,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDROCYCLOPENTA[A]PHENANTHREN 3 ONE; 17 (2,7 DIPHENYL 2H PYRAZOLO[3,4 D]PYRIDAZIN 4 YL) 10,13 DIMETHYL 1,2,6,7,8,9,10,11,12,13,1,4,15,16,17 TETRADECAHYDROCYCLOPENTA[A]PHENANTHREN 3 ONE; 4 (10,13 DIMETHYL 3 OXO 2,3,6,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 1H CYCLOPENTA[A]PHENANTHREN 17 YL) 2 PHENYL 2,5 DIHYDROPYRAZOLO[3,4 D]PYRIDAZIN 4 ONE; CHLORAMPHENICOL; ENAMINE; HETEROCYCLIC COMPOUND; HYDRAZONE DERIVATIVE; ISOXAZOLE DERIVATIVE; PREGNANE DERIVATIVE; PROGESTERONE DERIVATIVE; PYRAZOLE DERIVATIVE; TERBINAFINE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; BACILLUS SUBTILIS; BIOTRANSFORMATION; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; NONHUMAN; PENICILLIUM ITALICUM; PLANT FUNGUS INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; REACTION ANALYSIS; SACCHAROMYCES CEREVISIAE; STAPHYLOCOCCUS ALBUS; STRUCTURE ACTIVITY RELATION; SYNCEPHALASTRUM RACEMOSUM;

EID: 36749006024     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.5570440102     Document Type: Article

References (18)

1. T. Kwon, A. S. Heiman, E. T. Oriaku, K. Yoon, H. J. Lee, J. Med. Chem. 38(6), 1048 (1995).
2. D. P. Jindal, P. Piplani, H. Fajrak, C. Prior, I. G. Marshall, Eur. J. Med. Chem. 36, 195 (2001).
3. R. M. Hoyte, J. Zhong, R. Lerum, A. Oluyemi, P. Persaud, C. O'Connor, D. C., Labaree, R. B. Hochberg, J. Med. Chem., 45 (24), 5397 (2002).
4. E. J. Jacobsen, M. McCall, D. E. Ayer, F. J. Van Doorink, J. R. Palmer, K. L. Belonga, M. Broughler, E. D. Hall, D. J. Houser, M. A. Krook, T. A. Runge, J. Med. Chem., 33, 1145 (1990).
5. Y. Zhengqing, A. S. Heiman, C. E. Hudson, H. J. Lee, Steroids, 67, 353 (2002).
6. D. KO, A. S. Heiman, M. Chen, H. J. Lee, Steroids, 65, 210 (2000).
7. H. J. Lee, J. S. Cooperwood, Z. You, D. Ko, Arch. Pharm. Res., 25 (2), 111 (2002).
8. S. H. Doss, N. A. Louca, G. A. Elmegeed, R. M. Mohareb, Arch Pharm Res, 22, 495 (1999).
9. G. Hajos, Tetrahedron, Asymetry, 4 (3), 393 (1993).
10. R. Gupta, D. Pathak, D. P. Jindal, Eur. J. Med. Chem., 34, 659 (1999).
11. G. A. Elmegeed, W. W. Wardakhan, M. Younis, N. A. Louca, Arch. Pharm. Med. Chem., 337, 140 (2004).
12. W. B. Smith, Mag. Reson. Chem. 37(2), 103 (1999).
13. N. S. Bhacca, D. H. William, "Application of NMR spectroscopy inorganic chemistry", 1964, Holden Day, San Francisco.
14. W. E. Solomons, N. J. Doorenbos, J. Pharma. Sci., 63, 19 (1974).
15. G. Fravel, Bull. Soc. Chim. Fr., 31, 150 (1904).
16. N. F. Eweiss, A. Osman, Tetrahederon Lett., 1179 (1979).
17. C. Parkanyi, A. O. Abdelhamid, J. C. S. Cheng, A. S. Shawali, J. Heterocycl. Chem., 21, 1029 (1984).
18. A. O. Abdelhamid, F. A. Khalifa, S. S. Ghabrial, Phosphorus, Sulfur and Silicon, 40, 41 (1988).