Effect of chirality at C-20 of methyl 11β,17α,20-trihydroxy-3-oxo-1,4-pregnadien-21-oate derivatives on antiinflammatory activity

Steroids

Volumn 67, Issue 5, 2002, Pages 353-359

  You, Zhengqing ^a   Heiman, Ann S ^a   Hudson, Charles E ^a   Lee, Henry Joung ^a  

^a FLORIDA A AND M UNIVERSITY   (United States)

Author keywords

Acetonide; Antedrug; Anti inflammation; Chirality; Steroid methyl ester

Indexed keywords

GLUCOCORTICOID RECEPTOR; ISOFLUPREDONE; LIPOPOLYSACCHARIDE; METHYL 11BETA,17ALPHA,20 TRIHYDROXY 3 OXO 1,4 PREGNADIEN 21 OATE; METHYL 11BETA,17ALPHA,20 TRIHYDROXY 3 OXO 1,4 PREGNADIEN 21 OATE 17,20 ACETONIDE; METHYL 11BETA,17ALPHA,20 TRIHYDROXY 3 OXO 1,4 PREGNADIEN 21 OATE 17,20 CARBONATE; METHYL 11BETA,17ALPHA,20ALPHA TRIHYDROXY 9 ALPHA FLUORO 3 OXO 1,4 PREGNADIEN 21 OATE 17,20 ACETONIDE; METHYL 11BETA,17ALPHA,20ALPHA TRIHYDROXY 9ALPHA FLUORO 3 OXO 1,4 PREGNADIEN 21 OATE; METHYL 11BETA,17ALPHA,20ALPHA TRIHYDROXY 9ALPHA FLUORO 3 OXO 1,4 PREGNADIEN 21 OATE 17,20 CARBONATE; METHYL 11BETA,17ALPHA,20BETA TRIHYDROXY 9 ALPHA FLUORO 3 OXO 1,4 PREGNADIEN 21 OATE 17,20 CARBONATE; METHYL 11BETA,17ALPHA,20BETA TRIHYDROXY 9ALPHA FLUORO 3 OXO 1,4 PREGNADIEN 21 OATE; METHYL 11BETA,17ALPHA,20BETA TRIHYDROXY 9ALPHA FLUORO 3 OXO 1,4 PREGNADIEN 21 OATE 17,20 ACETONIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PREDNISOLONE; PREGNANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; BIOASSAY; CHIRALITY; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; IC 50; ISOMER; MACROPHAGE; MOUSE; NONHUMAN; STEREOCHEMISTRY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; FLUPREDNISOLONE; MACROPHAGES; MICE; NITRIC OXIDE; PREGNADIENES; PREGNADIENETRIOLS; PROTEIN BINDING; RECEPTORS, GLUCOCORTICOID;

EID: 0036192128     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(01)00189-1     Document Type: Article

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