Synthesis of halogen-substituted pyridyl and pyrimidyl derivatives of [3,2-c]pyrazolo corticosteroids: Strategies for the development of glucocorticoid receptor mediated imaging agents

Journal of Medicinal Chemistry

Volumn 45, Issue 24, 2002, Pages 5397-5405

  Hoyte, Robert M ^a   Zhang, Jing xin ^b   Lerum, Ronald ^a   Oluyemi, Aladejebi ^a   Persaud, Prita ^a   O'Connor, Craig ^b   Labaree, David C ^b   Hochberg, Richard B ^b  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b YALE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2' (2 FLUORO 5 PYRIDYL) 11BETA,17,21 TRIHYDROXY 16ALPHA METHYL 20 OXOPREGN 4 ENO[3,2 C]PYRAZOLE; 2' (3 PYRIDYL) 11BETA,17,21 TRIHYDROXY 16ALPHA METHYL 20 OXOPREGN 4 ENO[3,2 C]PYRAZOLE; CORTICOSTEROID DERIVATIVE; DEXAMETHASONE; FLUORINE; GLUCOCORTICOID RECEPTOR; HALOGEN; ISOTOPE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; WIN 44577;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; FEMALE; FLUORINATION; HALOGENATION; HELA CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMAGING; INFRARED SPECTROSCOPY; ISOTOPE LABELING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POSITRON EMISSION TOMOGRAPHY; TISSUE CULTURE;

ALKALINE PHOSPHATASE; ANIMALS; BINDING, COMPETITIVE; ENZYME INDUCTION; FLUORINE RADIOISOTOPES; GLUCOCORTICOIDS; HELA CELLS; HUMANS; ISOTOPE LABELING; LIGANDS; PREGNENES; PYRAZOLES; RADIOPHARMACEUTICALS; RATS; RECEPTORS, GLUCOCORTICOID;

EID: 0037153203     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0202775     Document Type: Article

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