Effects of nonsteroidal anti-inflammatory drugs on the expression of urokinase plasminogen activator and inhibitor and gelatinases in the early osteoarthritic knee of humans

Clinical Biochemistry

Volumn 41, Issue 1-2, 2008, Pages 109-116

  Yang, Shun Fa ^a   Hsieh, Yih Shou ^a   Lue, Ko Huang ^a   Chu, Shu Chen ^b   Chang, I Chang ^a,c   Lu, Ko Hsiu ^a,c  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Cyclooxygenase 2; MMP 2; MMP 9; NSAID; Osteoarthritis; PAI 1; u PA

Indexed keywords

CELECOXIB; DICLOFENAC; ETORICOXIB; GELATINASE A; GELATINASE B; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PLASMINOGEN ACTIVATOR INHIBITOR; ROFECOXIB; UROKINASE; VALDECOXIB;

ADULT; AGED; ARTICLE; ARTICULAR CARTILAGE; CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFECT; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME RELEASE; EX VIVO STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; KNEE MENISCUS; KNEE OSTEOARTHRITIS; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYNOVIUM; ZYMOGRAPHY;

AGED; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL SURVIVAL; CELLS, CULTURED; DISEASE PROGRESSION; FEMALE; GELATINASES; HUMANS; KNEE JOINT; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PLASMINOGEN ACTIVATOR INHIBITOR 1; SYNOVIAL MEMBRANE; TIME FACTORS; URINARY PLASMINOGEN ACTIVATOR;

EID: 36749005688     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2007.10.011     Document Type: Article

References (41)

1. Pelletier J.P., Martel-Pelletier J., and Howell D.S. Etiopathogenesis of osteoarthritis. In: Koopman W.J. (Ed). Arthritis and allied conditions: a textbook of rheumatology. 14th edition (2000), Williams & Wilkins, Baltimore 2195-2245
2. Hsieh Y.S., Yang S.F., Chu S.C., Chen P.N., Chou M.C., Hsu M.C., et al. Expression changes of gelatinases in human osteoarthritic knees and arthroscopic debridement. Arthroscopy 20 (2004) 482-488
3. Chu S.C., Yang S.F., Lue K.H., Hsieh Y.S., Hsiao T.Y., and Lu K.H. The clinical significance of gelatinase B in gouty arthritis of the knee. Clin Chim Acta 339 (2004) 77-83
4. Chu S.C., Yang S.F., Lue K.H., Hsieh Y.S., Lin Z.I., and Lu K.H. Clinical significance of gelatinases in septic arthritis of native and replaced knees. Clin Orthop Relat Res 427 (2004) 179-183
5. Koolwijk P., Miltenburg A.M., van Erck M.G., Oudshoorn M., Niedbala M.J., Breedveld F.C., et al. Activated gelatinase-B (MMP-9) and urokinase-type plasminogen activator in synovial fluids of patients with arthritis. Correlation with clinical and experimental variables of inflammation. J Rheumatol 22 (1995) 385-393
6. Lu K.H., Yang S.F., Chu S.C., Chen P.N., Chou M.C., Hsiao T.Y., et al. The significance of altered gelatinase expression in the synovium of patient with arthritic effusions. Clin Rheumatol 23 (2004) 21-26
7. Abramson S.B., Attur M., Amin A.R., and Clancy R. Nitric oxide and inflammatory mediators in the perpetuation of osteoarthritis. Curr Rheumatol Rep 3 (2001) 535-541
8. Pincus T. Clinical evidence for osteoarthritis as an inflammatory disease. Curr Rheumatol Rep 3 (2001) 524-534
9. Chu S.C., Yang S.F., Lue K.H., Hsieh Y.S., Wu C.L., and Lu K.H. Regulation of gelatinases expression by cytokines, endotoxin, and pharmacological agents in the human osteoarthritic knee. Connect Tissue Res 45 (2004) 142-150
10. Andreasen P.A., Georg B., Lund L.R., Riccio A., and Stacey S.N. Plasminogen activator inhibitors: hormonally regulated serpins. Mol Cell Endocrinol 68 (1990) 1-19
11. Daci E., Udagawa N., Martin T.J., Bouillon R., and Carmeliet G. The role of the plasminogen system in bone resorption in vitro. J Bone Miner Res 14 (1999) 946-952
12. Mazzieri R., Masiero L., Zanetta L., Monea S., Onisto M., Garbisa S., et al. Control of type IV collagenase activity by components of the urokinase-plasmin system: a regulatory mechanism with cell-bound reactants. EMBO J 16 (1997) 2319-2332
13. Ramos-DeSimone N., Hahn-Dantona E., Sipley J., Nagase H., French D.L., and Quigley J.P. Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion. J Biol Chem 274 (1999) 13066-13076
14. Matsuo O., Tanaka S., and Kikuchi H. Effect of urinary trypsin inhibitor on osteoarthritis. Thromb Res 52 (1988) 237-245
15. Chu S.C., Yang S.F., Lue K.H., Hsieh Y.S., Hsiao T.Y., and Lu K.H. Urokinase-type plasminogen activator, receptor, and inhibitor correlating with gelatinase-B (MMP-9) contribute to inflammation in gouty arthritis of the knee. J Rheumatol 33 (2006) 311-317
16. Weinberg J.B., Pippen A.M., and Greenberg C.S. Extravascular fibrin formation and dissolution in synovial tissue of patients with osteoarthritis and rheumatoid arthritis. Arthritis Rheum 34 (1991) 996-1005
17. Brommer E.J., Dooijewaard G., Dijkmans B.A., and Breedveld F.C. Plasminogen activators in synovial fluid and plasma from patients with arthritis. Ann Rheum Dis 51 (1992) 965-968
18. Vane J.R., Bakhle Y.S., and Botting R.M. Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol 38 (1998) 97-120
19. Dingle J.T. Non-steroidal anti-inflammatory drug administration in the treatment of Osteoarthritis. In: Reginster J.Y., Pelletier J.P., Martel-Pelletier J., and Henrotin Y. (Eds). Osteoarthritis: clinical and experiment aspects (1999), Springer, Berlin 370-387
20. Rainsford K.D., Ying C., and Smith F.C. Effects of meloxicam, compared with other NSAIDs, on cartilage proteoglycan metabolism, synovial prostaglandin E2, and production of interleukins 1, 6 and 8, in human and porcine explants in organ culture. J Pharm Pharmacol 49 (1997) 991-998
21. Blot L., Marcelis A., Devogelaer J.P., and Manicourt D.H. Effects of diclofenac, aceclofenac and meloxicam on the metabolism of proteoglycans and hyaluronan in osteoarthritic human cartilage. Br J Pharmacol 131 (2000) 1413-1421
22. Hsieh Y.S., Yang S.F., Lue K.H., Chu S.C., Li T.J., and Lu K.H. Upregulation of urokinase-type plasminogen activator and inhibitor and gelatinase expression via 3 mitogen-activated protein kinases and PI3K pathways during the early development of osteoarthritis. J Rheumatol 34 (2007) 785-793
23. Pelletier J.P., and Martel-Pelletier J. Effects of nimesulide and naproxen on the degradation and metalloprotease synthesis of human osteoarthritic cartilage. Drugs 46 Suppl 1 (1993) 34-39
24. Chu S.C., Yang S.F., Lue K.H., Hsieh Y.S., Lee C.Y., Chou M.C., et al. Glucosamine sulfate suppresses the expressions of urokinase plasminogen activator and inhibitor and gelatinases during the early stage of osteoarthritis. Clin Chim Acta 372 (2006) 167-172
25. Hsieh YS, Yang SF, Lue KH, Chu SC, Lu KH. Effects of different molecular weight hyaluronan products on the expression of urokinase plasminogen activator and inhibitor and gelatinases during the early stage of osteoarthritis. J Orthopaed Res; in press.
26. Oakley B.R., Kirsch D.R., and Morris N.R. A simplified ultrasensitive silver stain for detecting proteins in polyacrylamide gels. Anal Biochem 105 (1980) 361-363
27. Hsieh Y.S., Yang S.F., Lue K.H., and Lu K.H. Clinical correlation with the PA/plasmin system in septic arthritis of the knee. Clin Orthop Relat Res 447 (2006) 172-178
28. Campbell I.K., Piccoli D.S., Butler D.M., Singleton D.K., and Hamilton J.A. Recombinant human interleukin-1 stimulates human articular cartilage to undergo resorption and human chondrocytes to produce both tissue- and urokinase-type plasminogen activator. Biochim Biophys Acta 967 (1988) 183-194
29. Campbell I.K., Piccoli D.S., Roberts M.J., Muirden K.D., and Hamilton J.A. Effects of tumor necrosis factor alpha and beta on resorption of human articular cartilage and production of plasminogen activator by human articular chondrocytes. Arthritis Rheum 33 (1990) 542-552
30. Dingle J.T. The effects of NSAID on the matrix of human articular cartilages. Z Rheumatol 58 (1999) 125-129
31. Pelletier J.P. The influence of tissue cross-talking on OA progression: role of nonsteroidal antiinflammatory drugs. Osteoarthr Cartil 7 (1999) 374-376
32. Fujii K., Tajiri K., Kajiwara T., Tanaka T., and Murota K. Effects of NSAID on collagen and proteoglycan synthesis of cultured chondrocytes. J Rheumatol Suppl 18 (1989) 28-31
33. Pelletier J.P., Cloutier J.M., and Martel-Pelletier J. In vitro effects of tiaprofenic acid, sodium salicylate and hydrocortisone on the proteoglycan metabolism of human osteoarthritic cartilage. J Rheumatol 16 (1989) 646-655
34. Smith R.L., Kajiyama G., and Lane N.E. Nonsteroidal antiinflammatory drugs: effects on normal and interleukin 1 treated human articular chondrocyte metabolism in vitro. J Rheumatol 22 (1995) 1130-1137
35. Colombo C., Butler M., Hickman L., Selwyn M., Chart J., and Steinetz B. A new model of osteoarthritis in rabbits: II. Evaluation of anti-osteoarthritic effects of selected antirheumatic drugs administered systemically. Arthritis Rheum 26 (1983) 1132-1139
36. Sadowski T., and Steinmeyer J. Effects of non-steroidal antiinflammatory drugs and dexamethasone on the activity and expression of matrix metalloproteinase-1, matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 by bovine articular chondrocytes. Osteoarthr Cartil 9 (2001) 407-415
37. Hamilton J.A., Vairo G., Knight K.R., and Cocks B.G. Activation and proliferation signals in murine macrophages. Biochemical signals controlling the regulation of macrophage urokinase-type plasminogen activator activity by colony-stimulating factors and other agents. Blood 77 (1991) 616-627
38. Mochan E., Uhl J., and Newton R. Evidence that interleukin-1 induction of synovial cell plasminogen activator is mediated via prostaglandin E2 and cAMP. Arthritis Rheum 29 (1986) 1078-1084
39. Pelletier J.P., Mineau F., Fernandes J., Kiansa K., Ranger P., and Martel-Pelletier J. Two NSAIDs, nimesulide and naproxen, can reduce the synthesis of urokinase and IL-6 while increasing PAI-1, in human OA synovial fibroblasts. Clin Exp Rheumatol 15 (1997) 393-398
40. Hamilton J.A., Cheung D., Filonzi E.L., Piccoli D.S., Wojta J., Gallichio M., et al. Independent regulation of plasminogen activator inhibitor 2 and plasminogen activator inhibitor 1 in human synovial fibroblasts. Arthritis Rheum 35 (1992) 1526-1534
41. Nakamura H., Masuko K., Yudoh K., Kato T., and Nishioka K. Effects of celecoxib on human chondrocytes-enhanced production of chemokines. Clin Exp Rheumatol 25 (2007) 11-16