GABAA-receptor modification in taurine transporter knockout mice causes striatal disinhibition

Journal of Physiology

Volumn 585, Issue 2, 2007, Pages 539-548

  Sergeeva, Olga A ^a   Fleischer, W ^a   Chepkova, A N ^a   Warskulat, U ^a   Haussinger D ^a   Siebler, M ^a   Haas, H L ^b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BICUCULLINE; GLYCINE RECEPTOR; TAURINE; TAURINE TRANSPORTER; VIGABATRIN; ZOLPIDEM; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; CARRIER PROTEIN; GABAERGIC RECEPTOR AFFECTING AGENT; TAURINE TRANSPORT PROTEIN, MOUSE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; KNOCKOUT MOUSE; MEMBRANE CURRENT; MOUSE; NERVE CELL CULTURE; NERVE CELL MEMBRANE POTENTIAL; NERVE CELL PLASTICITY; NERVE CONDUCTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; STRIATE CORTEX; WILD TYPE; AMINO ACID DEFICIENCY; ANIMAL TISSUE; CELL ISOLATION; CONTROLLED STUDY; CORPUS STRIATUM; DISINHIBITION; EVOKED RESPONSE; NERVOUS SYSTEM PARAMETERS; RECEPTOR SENSITIVITY; TAURINE DEFICIENCY; WHOLE CELL PATCH CLAMP; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECT; FEMALE; GENETICS; INHIBITORY POSTSYNAPTIC POTENTIAL; MALE; MOUSE MUTANT; NERVE CELL INHIBITION; PHYSIOLOGY;

ANIMALS; BICUCULLINE; CELLS, CULTURED; CORPUS STRIATUM; FEMALE; GABA AGENTS; GABA ANTAGONISTS; INHIBITORY POSTSYNAPTIC POTENTIALS; MALE; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, KNOCKOUT; NEURAL INHIBITION; RECEPTORS, GABA-A; TAURINE; VIGABATRIN;

EID: 36649031400     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2007.141432     Document Type: Article

References (29)

1. Ahboucha S & Butterworth RF (2004). Pathophysiology of hepatic encephalopathy: A new look at GABA from the molecular standpoint. Metab Brain Dis 19, 331-343.
2. Ahboucha S, Pomier-Layrargues G, Mamer O & Butterworth RF (2006). Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma. Neurochem Int 49, 372-378.
3. Butterworth RF (1996). Taurine in hepatic encephalopathy. Adv Exp Med Biol 403, 601-606.
4. Chepkova AN, Sergeeva OA & Haas HL (2006). Taurine rescues hippocampal long-term potentiation from ammonia-induced impairment. Neurobiol Dis 23, 512-521.
5. 3 H]taurine into medium-size neurons and into identified striatonigral neurons in the rat neostriatum. Brain Res 289, 342-348.
6. A receptor desensitization: The role of the gamma 2 subunit and its physiological significance. J Physiol 497, 145-159.
7. A receptors. Nat Rev Neurosci 6, 215-229.
8. Graybiel AM (1995). The basal ganglia. Trends Neurosci 18, 60-62.
9. Hablitz JJ, Tehrani MH & Barnes EM Jr (1989). Chronic exposure of developing cortical neurons to GABA down-regulates GABA/benzodiazepine receptors and GABA-gated chloride currents. Brain Res 501, 332-338.
10. Haussinger D, Schliess F & Kircheis G (2002). Pathogenesis of hepatic encephalopathy. J Gastroenterol Hepatol 17 (Suppl. 3), S256-S259.
11. Haussinger D, vom Laubenberger JDS, Ernst T, Bayer S, Langer M, Gerok W & Hennig J (1994). Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy. Gastroenterology 107, 1475-1480.
12. Heller-Stilb B, van Roeyen C, Rascher K, Hartwig HG, Huth A, Seeliger MW, Warskulat U & Haussinger D (2002). Disruption of the taurine transporter gene (taut) leads to retinal degeneration in mice. FASEB J 16, 231-233.
13. Hussy N, Deleuze C, Pantaloni A, Desarmenien MG & Moos F (1997). Agonist action of taurine on glycine receptors in rat supraoptic magnocellular neurones: Possible role in osmoregulation. J Physiol 502, 609-621.
14. Huxtable RJ (1992). Physiological actions of taurine. Physiol Rev 72, 101-163.
15. A receptor mRNAs and increases ligand binding. J Neurochem 61, 2334-2337.
16. 35 S]butylbicyclophosphorothionate binding by antagonists: Relationship to patterns of subunit expression. J Neurochem 66, 2179-2187.
17. A subclass of GABA receptors. J Neurochem 74, 2087-2093.
18. Otto F, Gortz P, Fleischer W & Siebler M (2003). Cryopreserved rat cortical cells develop functional neuronal networks on microelectrode arrays. J Neurosci Methods 128, 173-181.
19. A receptors in central synapses. J Neurosci 19, 578-588.
20. A receptor stimulation. J Neurochem 68, 631-639.
21. Saransaari P & Oja SS (2000). Taurine and neural cell damage. Amino Acids 19, 509-526.
22. A receptors in rat hypothalamic neurons expressing the ε-subunit. J Neurosci 25, 88-95.
23. Sergeeva OA, Chepkova AN, Doreulee N, Eriksson KS, Poelchen W, Monnighoff I, Heller-Stilb B, Warskulat U, Haussinger D & Haas HL (2003). Taurine-induced long-lasting enhancement of synaptic transmission in mice: Role of transporters. J Physiol 550, 911-919.
24. Sergeeva OA & Haas HL (2001). Expression and function of glycine receptors in striatal cholinergic interneurons from rat and mouse. Neuroscience 104, 1043-1055.
25. Timmermann L, Gross J, Butz M, Kircheis G, Haussinger D & Schnitzler A (2004). Pathological oscillatory coupling within the human motor system in different tremor syndromes as revealed by magnetoencephalography. Neurol Clin Neurophysiol 2004, 26.
26. Warskulat U, Flogel U, Jacoby C, Hartwig HG, Thewissen M, Merx MW, Molojavyi A, Heller-Stilb B, Schrader J & Haussinger D (2004). Taurine transporter knockout depletes muscle taurine levels and results in severe skeletal muscle impairment but leaves cardiac function uncompromised. FASEB J 18, 577-579.
27. Weissenborn K & Kolbe H (1998). The basal ganglia and portal-systemic encephalopathy. Metab Brain Dis 13, 261-272.
28. Wong LS, Eshel G, Dreher J, Ong J & Jackson DM (1991). Role of dopamine and GABA in the control of motor activity elicited from the rat nucleus accumbens. Pharmacol Biochem Behav 38, 829-835.
29. Wu Y, Wang W & Richerson GB (2003). Vigabatrin induces tonic inhibition via GABA transporter reversal without increasing vesicular GABA release. J Neurophysiol 89, 2021-2034.