Folate and colo-rectal cancer risk

British Journal of Nutrition

Volumn 98, Issue 6, 2007, Pages 1299-1304

  Sanderson, Peter ^a   Stone, Elaine ^a   Kim, Young In ^b   Mathers, John C ^c   Kampman, Ellen ^d   Downes, C Stephen ^e   Muir, Kenneth R ^f   Baron, John A ^g  

^a FOOD STANDARDS AGENCY   (United Kingdom)

^b UNIVERSITY OF TORONTO   (Canada)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d WAGENINGEN UNIVERSITY   (Netherlands)

^e UNIVERSITY OF ULSTER   (United Kingdom)

^f UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^g DARTMOUTH COLLEGE   (United States)

Author keywords

Colo rectal cancer; Folate; Folic acid; Food Standards Agency

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ACETYLSALICYLIC ACID; CARCINOGEN; FLUOROURACIL; FOLIC ACID; HOMOCYSTEINE; PLACEBO; RIBOFLAVIN; URACIL;

ADENOMATOUS POLYP; CANCER RISK; CARCINOGENESIS; CLINICAL TRIAL; COLORECTAL ADENOMA; COLORECTAL CANCER; CONFERENCE PAPER; DIET SUPPLEMENTATION; DIETARY INTAKE; DNA METHYLATION; GENETIC ANALYSIS; GENETIC POLYMORPHISM; HUMAN; MEDICAL RESEARCH; NONHUMAN; UNITED KINGDOM; VITAMIN SUPPLEMENTATION; WORKSHOP;

COLORECTAL NEOPLASMS; DIETARY SUPPLEMENTS; FOLIC ACID; FOLIC ACID DEFICIENCY; FOOD, FORTIFIED; GOVERNMENT AGENCIES; GREAT BRITAIN; HUMANS; RISK ASSESSMENT;

CITRUS MACROPHYLLA;

EID: 36649028057     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114507771908     Document Type: Conference Paper

References (40)

1. Sanjoaquin MA, Allen N, Couto E, Roddam AW & Key TJ (2005) Folate intake and colorectal cancer risk: A meta-analytical approach. Int J Cancer 113, 825-828.
2. Larsson SC, Giovannucci E & Wolk A (2005) A prospective study of dietary folate intake and risk of colorectal cancer: Modification by caffeine intake and cigarette smoking. Cancer Epidemiol Biomarkers Prev 14, 740-743.
3. Van Guelpen B, Hultdin J, Johansson I, Hallmans G, Stenling R, Riboli E, Winkvist A & Palmqvist R (2006) Low folate levels may protect against colorectal cancer. Gut 55, 1461-1466.
4. Zhang SM, Moore SC, Lin J, Cook NR, Manson JE, Lee IM & Buring JE (2006) Folate, Vitamin B6, Multivitamin Supplements, and Colorectal Cancer Risk in Women. Am J Epidemiol 163, 108-115.
5. Baron JA, Sandler RS, Haile RW, Mandel JS, Mott LA & Greenberg ER (1998) Folate intake, alcohol consumption, cigarette smoking, and risk of colorectal adenomas. J Natl Cancer Inst 90, 57-62.
6. Giovannucci E, Stampfer MJ, Colditz GA, Rimm EB, Trichopoulos D, Rosner BA, Speizer FE & Willett WC (1993) Folate, methionine, and alcohol intake and risk of colorectal adenoma. J Natl Cancer Inst 85 875-884.
7. Martinez ME, Henning SM & Alberts DS (2004) Folate and colorectal neoplasia: Relation between plasma and dietary markers of folate and adenoma recurrence. Am J Clin Nutr 79, 691-697.
8. Sharp L & Little J (2004) Polymorphisms in Genes Involved in Folate Metabolism and Colorectal Neoplasia: A HuGE Review. Am J Epidemiol 159, 423-443.
9. Bingham SA, Norat T, Moskal A, et al. (2005) Is the association with fiber from foods in colorectal cancer confounded by folate intake? Cancer Epidemiol Biomarkers Prev 14, 1552-1556.
10. Cravo ML, Mason JB, Dayal Y, Hutchinson M, Smith D, Selhub J & Rosenberg IH (1992) Folate deficiency enhances the development of colonic neoplasia in dimethylhydrazine-treated rats. Cancer Res 52, 5002-5006.
11. Kim YI, Salomon RN, Graeme-Cook F, Choi SW, Smith DE, Dallal GE & Mason JB (1996) Dietary folate protects against the development of macroscopic colonic neoplasia in a dose responsive manner in rats. Gut 39 732-740.
12. Wargovich MJ, Chen CD, Jimenez A, Steele VE, Velasco M, Stephens LC, Price R, Gray K & Kelloff GJ (1996) Aberrant crypts as a biomarker for colon cancer: Evaluation of potential chemopreventive agents in the rat. Cancer Epidemiol Biomarkers Prev 5, 355-360.
13. Le Leu RK, Young GP & McIntosh GH (2000) Folate deficiency reduces the development of colorectal cancer in rats. Carcinogenesis 21, 2261-2265.
14. Le Leu RK, Young GP & McIntosh GH (2000) Folate deficiency diminishes the occurrence of aberrant crypt foci in the rat colon but does not alter global DNA methylation status. J Gastroenterol Hepatol 15 1158-1164.
15. Wargovich MJ, Jimenez A, McKee K, Steele VE, Velasco M, Woods J, Price R, Gray K & Kelloff GJ (2000) Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression. Carcinogenesis 21, 1149-1155.
16. Bashir O, FitzGerald AJ & Goodlad RA (2004) Both suboptimal and elevated vitamin intake increase intestinal neoplasia and alter crypt fission in the ApcMin/+ mouse. Carcinogenesis 25, 1507-1515.
17. Song J, Sohn KJ, Medline A, Ash C, Gallinger S & Kim YI (2000) Chemopreventive effects of dietary folate on intestinal polyps in Apc+/ -Msh2-/- mice. Cancer Res 60, 3191-3199.
18. Song J, Medline A, Mason JB, Gallinger S & Kim YI (2000) Effects of dietary folate on intestinal tumorigenesis in the apcMin mouse. Cancer Res 60, 5434-5440.
19. Lindzon GM, Medline A, Sohn KJ, Gallinger S, Croxford R & Kim YI (in press) Effect of folic acid supplementation on the progression of colorectal aberrant crypt foci. Proc Am Assoc Cancer Res.
20. Jones PA & Baylin SB (2002) The fundamental role of epigenetic events in cancer. Nat Rev Genet 3, 415-428.
21. Feinberg AP, Ohlsson R & Henikoff S (2006) The epigenetic progenitor origin of human cancer. Nat Rev Genet 7, 21-33.
22. Duthie SJ, Narayanan S, Sharp L, Little J, Basten G & Powers H (2004) Folate, DNA stability and colo-rectal neoplasia. Proc Nutr Soc 63, 571-578.
23. van den Donk M, van Engeland M, Pellis L, Witteman BJM, Kok FJ, Keijer J & Kampman E (2007) Dietary folate intake in combination with MTHFR C677T genotype and promoter methylation of tumor suppressor and DNA repair genes in sporadic colorectal adenomas. Cancer Epidemiol Biomarkers Prev 16, 327-333.
24. Hubner RA, Muir KR, Liu JF, Sellick GS, Logan RFA, Grainge M, Armitage N, Chau I & Houlston RS & The United Kingdom Colorectal Adenoma Prevention Consortium (2006) Folate metabolism polymorphisms influence risk of colorectal adenoma recurrence. Cancer Epidemiol Biomarkers Prev 15, 1607-1613.
25. Quinlivan EP & Gregory JF III (2003) Effect of food fortification on folic acid intake in the United States. Am J Clin Nutr 77, 221-225.
26. Ulrich CM & Potter JD (2006) Folate supplementation: Too much of a good thing? Cancer Epidemiol Biomarkers Prev 15, 189-193.
27. Mathers JC (2005) Reversal of DNA hypomethylation by folic acid supplements: Possible role in colorectal cancer prevention. Gut 54, 579-581.
28. Kim YI, Baik HW, Fawaz K, Knox T, Lee YM, Norton R, Libby E & Mason JB (2001) Effects of folate supplementation on two provisional molecular markers of colon cancer: A prospective, randomized trial. Am J Gastroenterol 96, 184-195.
29. Pufulete M, Al Ghnanjem R, Khushal A, Appleby P, Harris N, Gout S, Emery PW & Sanders TAB (2005) Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma. Gut 54, 648-653.
30. Jacob RA, Gretz DM, Taylor PC, James SJ, Pogribny IP, Miller BJ, Henning SM & Swendseid ME (1998) Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women. J Nutr 128, 1204-1212.
31. Rampersaud GC, Kauwell GP, Hutson AD, Cerda JJ & Bailey LB (2000) Genomic DNA methylation decreases in response to moderate folate depletion in elderly women. Am J Clin Nutr 72, 998-1003.
32. Shelnutt KP, Kauwell GP, Gregory JF III, Maneval DR, Quinlivan EP, Theriaque DW, Henderson GN & Bailey LB (2004) Methylenetetrahydrofolate reductase 677C- > T polymorphism affects DNA methylation in response to controlled folate intake in young women. J Nutr Biochem 15, 554-560.
33. Basten GP, Duthie SJ, Pirie L, Vaughan N, Hill MH & Powers FU (2006) Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers. Br J Cancer 94 1942-1947.
34. Shen L, Kondo Y, Rosner GL, et al. (2005) MGMT promoter methylation and field defect in sporadic colorectal cancer. J Natl Cancer Inst 97, 1330-1338.
35. Giovannucci E & Ogino S (2005) DNA methylation, field effects, and colorectal cancer. J Natl Cancer Inst 97, 1317-1319.
36. Wright AJA, Finglas PM, Dainty JR, Wolfe CA, Hart DJ, Wright DM & Gregory JF (2005) Differential kinetic behavior and distribution for pteroylglutamic acid and reduced folates: A revised hypothesis of the primary site of PteGlu metabolism in humans. J Nutr 135, 619-623.
37. Kelly P, McPartlin J, Goggins M, Weir DG & Scott JM (1997) Unmetabolized folic acid in serum: Acute studies in subjects consuming fortified food and supplements. Am J Clin Nutr 65, 1790-1795.
38. Sweeney MR, McPartlin J, Weir DG, Daly L & Scott JM (2006) Postprandial serum folic acid response to multiple doses of folic acid in fortified bread. Br J Nutr 95, 145-151.
39. Troen AM, Mitchell B, Sorensen B, et al. (2006) Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr 136, 189-194.
40. Imai K, Matsuyama S, Miyake S, Suga K & Nakachi K (2000) Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population. Lancet 356 1795-1799.