Folate deficiency diminishes the occurrence of aberrant crypt foci in the rat colon but does not alter global DNA methylation status

Journal of Gastroenterology and Hepatology (Australia)

Volumn 15, Issue 10, 2000, Pages 1158-1164

  Le Leu, Richard K ^a,b   Young, Graeme P ^c   McIntosh, Graeme H ^a,b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b CSIRO   (Australia)

^c FLINDERS MEDICAL CENTRE   (Australia)

Author keywords

Aberrant crypt foci; DNA hypomethylation; Folate; Folate deficiency

Indexed keywords

AZOXYMETHANE; DNA; FOLIC ACID; SUCCINYLSULFATHIAZOLE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; COLON CARCINOGENESIS; COLON MUCOSA; COLORECTAL CARCINOMA; CONTROLLED STUDY; CRYPT CELL; DNA METHYLATION; FOLIC ACID BLOOD LEVEL; FOLIC ACID DEFICIENCY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033695424     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1746.2000.02327.x     Document Type: Article

References (47)

1. Nutritional anaemias
2. 6 occur commonly in elderly people
3. Nutritional factors in colorectal cancer risk: A case-control study in Majorca
4. Folate intake and carcinogenesis of the colon and rectum
5. Folate, methionine and alcohol intake and risk of colorectal adenoma
6. Selected micronutrient intake and the risk of colorectal cancer
7. Alcohol, low-methionine-low folate diets, and risk of colon cancer in men
8. Red cell and plasma folate, folate consumption, and the risk of colorectal adenomatous polyps
9. Folate and alcohol intakes: Related or independent roles in the adenoma-carcinoma sequence?
10. Micronutrients and the risk of colorectal adenomas
11. Folate intake, alcohol consumption, cigarette smoking, and risk of colorectal adenomas
12. Alcohol and nutrients in relation to colon cancer in middle-aged adults
13. Serum folate and chronic disease risk: Findings from a cohort of United States adults
14. Aberrant crypts as a biomarker for colon cancer: Evaluation of potential chemopreventive agents in the rat
15. Folate deficiency enhances the development of colonic neoplasia in dimethylhydrazine-treated rats
16. Dietary folate protects against the development of macroscopic colonic neoplasia in a dose responsive manner in rats
17. Folate and colonic carcinogenesis: Searching for a mechanistic understanding
18. Folate: Its metabolism and utilization
19. Reduced genomic 5-methylcytosine content in human colonic neoplasia
20. Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies
21. Aberrant crypts: Potential preneoplastic lesions in the murine colon
22. Observation and quantitation of aberrant crypts in the murine colon treated with a colon carcinogen: Preliminary findings
23. Comparison of a HPLC and radioprotein-binding assay for the determination of folates in milk and blood samples
24. High performance liquid chromatography method for rapid and accurate determination of homocysteine in plasma and serum
25. 6 deficiency on these concentrations in rat liver
26. DNA methylation in folate deficiency
27. Role of aberrant crypt foci in understanding the pathogenesis of colon cancer
28. Aberrant crypts in human colonic mucosa: Putative preneoplastic lesions
29. Aberrant crypt foci in patients with colorectal cancer
30. Bacterially synthesized folate in rat large intestine is incorporated into the host tissue folyl polyglutamates
31. Folate synthesized by bacteria in the human upper small intestine is assimilated by the host
32. Ability of endogenous folate from soy protein isolate to maintain plasma homocysteine and hepatic DNA methylation during methyl group depletion in rats
33. Moderate folate deficiency does not cause global hypomethylation of hepatic and colonic DNA or c-myc specific hypomethylation of colonic DNA in rats
34. Folate deficiency induced homocysteinaemia in rats: Disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism
35. Folate deficiency in rats fed diets containing free amino acids or intact proteins
36. Folic acid and unconjugated pteridines
37. Rapid appearance of hypomethylated DNA in livers of rats fed cancer-promoting methyl-deficient diets
38. Folate deficiency in rats induces strand breaks and hypomethylation within the p53 tumor suppressor gene
39. DNA hypomethylation and hepatocarcinogenesis in rats fed a choline-devoid diet
40. Ability of aberrant crypt foci characteristics to predict colonic tumor incidence in rats fed cholic acid
41. Promotion of colonic microadenoma growth in mice fed cooked sugar or cooked casein and fat
42. Effect of dietary fat on colonic protein kinase C and induction of aberrant crypt foci
43. Characterisation of aberrant crypt foci in carcinogen-treated rats: Association with intestinal carcinogenesis
44. Colon carcinogenesis in germ-free rats with intracaecal 1,2-dimethylhydrazine and subcutaneous azoxymethane
45. Chemical induction of colon tumours in animals: An overview
46. Biochemical role of folate in cellular metabolism
47. Antimetabolites in cancer therapy