Aspartame bioassay findings portend human cancer hazards

International Journal of Occupational and Environmental Health

Volumn 13, Issue 4, 2007, Pages 446-448

  Huff, James ^a   LaDou, Joseph ^b  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aspartame

Indexed keywords

1,3 BUTADIENE; 2 NAPHTHYLAMINE; ASPARTAME; CARCINOGEN; DIETHYLSTILBESTROL; DIOXIN; DOMESTIC CHEMICAL; ETHYLENE OXIDE; FORMALDEHYDE; VINYL CHLORIDE;

BIOASSAY; BRAIN DAMAGE; CANCER RISK; CARCINOGENESIS; COST BENEFIT ANALYSIS; FOOD AND DRUG ADMINISTRATION; HEALTH CARE PERSONNEL; HEALTH SERVICE; HUMAN; INDUSTRIAL WORKER; NONHUMAN; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SHORT SURVEY; UTERINE CERVIX CANCER;

EID: 36549090520     PISSN: 10773525     EISSN: None     Source Type: Journal    
DOI: 10.1179/oeh.2007.13.4.446     Document Type: Short Survey

References (40)

1. Soffritti M, Belpoggi F, Tibaldi E, Esposito DD, Lauriola M. Lifespan exposure to low doses of aspartame beginning during prenatal life increases cancer effects in rats. Environ Health Perspect. 2007;115:1293-7.
2. Soffritti M, Belpoggi F, Degli Esposti D, Lambertini L, Tibaldi E, Rigano A. First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats. Environ Health Perspect. 2006;114: 379-85.
3. Belpoggi F, Soffritti M, Padovani M, Degli Esposti D, Lauriola M, Minardi F. Results of long-term carcinogenicity bioassay on Sprague-Dawley rats exposed to aspartame administered in feed. Ann NY Acad Sci. 2006;1076:559-77.
4. FDA Statement on European Aspartame Study, Center for Food Safety and Applied Nutrition, April 20, 2007. 〈http://www. cfsan.fda.gov/~lrd/ fpaspar2.html〉.
5. Galore Control Council. Overwhelming scientific evidence confirms safety of aspartame. FDA, others affirm safety of aspartame, 2007. 〈http://www. aspartame.org/documents/RAM07.doc〉.
6. Huff J. Value, validity, and historical development of carcinogenesis studies for predicting and confirming carcinogenic risks to humans. Chapter 2:21-123. In: Kitchin KT (ed). Carcinogenicity Testing, Predicting, & Interpreting Chemical Effects. New York: Marcel Dekker, 1999.
7. Soffritti M, Belpoggi F, Minardi F, Maltoni C. Ramazzini Foundation cancer program: history and major projects, life-span carcinogenicity bioassay design, chemicals studied, and results. Ann NY Acad Sci. 2002;982:26-45.
8. Tomatis L Identification of carcinogenic agents and primary-prevention of cancer. Ann NY Acad Sci. 2006;1076:1-14.
9. Tomatis L, Huff J. Evolution of cancer etiology and primary prevention. Environ Health Perspect. 2001;109:A458-60.
10. Rall DP. Laboratory animal tests and human cancer. Drug Metab Rev. 2000;32:119-28.
11. Rail DP. Shoe-leather epidemiology - the footpads of mice and rats: animal tests in assessment of occupational risks. Mt Sinai J Med. 1994;61:504-8.
12. Huff J. Chemicals studied and evaluated in long-term carcinogenesis bioassays by both the Ramazzini Foundation and the National Toxicology Program: in tribute to Cesare Maltoni and David Rall. Ann NY Acad Sci. 2002;982:208-30.
13. Huff J. Chemicals causally associated with cancers in humans and in laboratory animals: a perfect concordance. Chapter 2: 25-37. In: Waalkes MP, Ward JM (eds). Carcinogenesis. New York: Raven Press, 1994.
14. Tomatis L, Huff J, Hertz-Picciotto I, et al. Avoided and avoidable risks of cancer. Carcinogenesis. 1997;18:97-105.
15. Maltoni C, Soffritti M, Belpoggi F. The scientific and methodological bases of experimental studies for detecting and quantifying carcinogenic risks. Ann NY Acad Sci. 1999;895:10-26.
16. Huff J. Long-term chemical carcinogenesis bioassays predict human cancer hazards. Issues, controversies, and uncertainties. Ann NY Acad Sci. 1999;895:56-79.
17. Tomatis L, Melnick RL, Haseman J, Barrett JC, Huff J. Alleged misconceptions distort perceptions of environmental cancer risks. FASEBJ. 2001;15:195-203.
18. Haseman J, Melnick R, Tomatis L, Huff J. Carcinogenesis bioassays: study duration and biological relevance. Food Chem Toxicol. 2001;39:739-44.
19. Maronpot RR, Flake G, Huff J. Relevance of animal carcinogenesis findings to human cancer predictions and prevention. Toxicol Pathol. 2004;32 suppl 1:40-8.
20. Dunnick JK, Hailey JR. Phenolphthalein exposure causes multiple carcinogenic effects in experimental model systems. Cancer Res. 1996;56:4922-6.
21. Huff J, Melnick R. What are the real causes of cancer? Int J Occup Environ Health. 2006;12:81-6.
22. Tomatis L, Huff J. Evolution of research on cancer etiology. Chapter 9:189-201. In: Coleman WB, Tsongalis GJ (eds). The Molecular Basis of Human Cancer: Genomic Instability and Molecular Mutation in Neoplastic Transformation. Totowa, NJ: Humana Press, 2002.
23. China aspartame. 〈http://www.alibaba.com/countrysearch/ CN-suppliers/Aspartame.html〉.
24. China aspartame manufacturers. 〈http://www.made-in-china. com/china-products/productviewvfgEcArlqmiw/Aspartame. html〉.
25. Lim U, Subar AF, Mouw T, et al. Consumption of aspartamecontaining beverages and incidence of hematopoietic and brain malignancies. Cancer Epidemiol Biomarkers Prev. 2006;15:1654-9.
26. Gallus S, Scotti L, Negri E, et al. Artificial sweeteners and cancer risk in a network of case-control studies. Ann Oncol. 2007;18:40-4.
27. Huff J, Castleman B, LaDou J, et al., Primary prevention of cancer. The Scientist. 2002 Sep 16;16(18):10-11.
28. FDA. Aspartame: Commissioners Final Decision. Fed Reg. 1981 July 24;46[142]:38235-308.
29. Congress. GAO Investigating NutraSweet approval. UPI, reprinted in Congressional Record, August 1, 1985, p S10823.
30. Gordon G. NutraSweet: questions swirl. UPI Investigative Report, 10/12/87. Reprinted in U.S. Senate, 1987, pp 483-510.
31. Gordon G. FDA resisted proposals to test aspartame for years. Star Tribune. 22 Nov 1996.
32. Jacobson M, Huff J. Are 2-year exposure regimens optimum for identifying chemical carcinogens? Environ Health Perspect. 2007 [submitted]
33. History of aspartame, 〈http://www.dorway.com/enclosur.html〉.
34. Preapproval "research" & history of aspartame. 〈http://www. holisticmed.com/aspartame/history.faq〉.
35. Granitic Believers, 〈http://presidiotex.com/nutrapoison/ believers.html〉.
36. The Good Stuff. 〈http://presidiotex.com/nutrapoison/stuff. html〉.
37. Donald Rumsfeld and aspartame. 〈http://www.newswithviews. com/NWVexclusive/exclusive15.htm〉.
38. Connection between Donald Rumsfeld and Dr. Arthur Hayes. 〈http://www.politicalfriendster.com/showConnection.php?id1 =56&id2=2770〉.
39. Aspartame Warning, 〈http://www.321recipes.com/aspartame. html〉.
40. Abdo KM, Camargo CA Jr, Davis D, et al. Letter to U.S. FDA Commissioner. Int J Occup Environ Health. 2007;13:453-4.