Cytokine response to strenuous exercise in athletes and non-athletes-an adaptive response

Cytokine

Volumn 40, Issue 2, 2007, Pages 123-127

  Gokhale, Rohit ^a   Chandrashekara, S ^b   Vasanthakumar, K C ^a  

^a M S RAMAIAH MEDICAL COLLEGE   (India)

^b Chanre Rheumatology and Immunology Center and Research   (India)

Author keywords

Adaptation; Athletes and non athletes; IL 6; Pro inflammatory cytokines; Strenuous exercise; TNF

Indexed keywords

CYTOKINE; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; ATHLETE; CONTROLLED STUDY; ENZYME IMMUNOASSAY; EXERCISE; GROUPS BY AGE; HUMAN; HUMAN EXPERIMENT; MALE; PRIORITY JOURNAL; SEX DIFFERENCE; TRAINING;

ADAPTATION, PHYSIOLOGICAL; ADOLESCENT; ADULT; EXERCISE; HUMANS; INTERLEUKIN-6; MALE; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 36549080066     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2007.08.006     Document Type: Article

References (29)

1. Pedersen B.K., and Anders D.T. Effects of exercise on the lymphocytes and cytokine-. Br J Sports Med 34 (2000) 246-251
2. Nieman D.C., and Hoffman-Goetz L. In: Hoffman-Goetz L. (Ed). Exercise and immune function (1996), CRC Press, New York 143-162
3. Alexandra M., Katerina S., Maria T., Eugenia H., Antonia-Leda M., et al. Dramatic elevations of interleukin-6 and acute-phase reactants in athletes participating in the ultradistance foot race spartathlon: severe systemic inflammation and lipid and lipoprotein changes in protracted exercise. J Clin Endocrinol Metab 90 (2005) 3914-3918
4. Pedersen B.K., Steensberg A., Fischer C., et al. Searching for the exercise factor-is IL-6 a candidate. J Muscle Res Cell Motil 24 (2003) 113-119
5. Febbraio M.A., and Pedersen B.K. Muscle-derived interleukin-6: mechanisms for activation and possible biological roles. FASEB J 16 (2002) 1335-1347
6. Pedersen B.K., Steensberg A., and Schjerling P. Muscle-derived interleukin-6: possible biological effects. J Physiol (London) 536 (2001) 329-337
7. Pedersen B.K., and Hoffman-Goetz L. Exercise and the immune system: regulation, integration and adaption. Physiol Rev 80 (2000) 1055-1081
8. Moldoveanu A.I., Shephard R.J., and Shek P.N. Exercise elevates plasma levels but not gene expression of IL-1β, IL-6, and TNF-α in blood mononuclear cells. J Appl Physiol 89 (2000) 1499-1504
9. Baj Z., Kantorski J., Lewicki R., et al. Immunological status of competitive cyclists before and after the training season. Int J Sports Med 15 (1994) 319-324
10. Nieman D.C., Buckley K.S., Nehlsen Cannarella S.L., et al. Immune function in marathon runners versus sedentary controls. Med Sci Sports Exerc 27 (1995) 986-992
11. Hack V., Strobel G., Weicker H., et al. PMN cell counts and phagocytic activity of highly trained athletes depend on training period. J Appl Physiol 77 (1994) 1731-1735
12. Pedersen B.K., Tvede N., Halkjær Kristensen J., et al. Natural killer cell activity in peripheral blood of highly trained and untrained persons. Int J Sports Med 10 (1989) 129-131
13. Pyne D.B., Baker M.S., Weidemann M.J., et al. Effects of an intensive 12-wk training program by elite swimmers on neutrophil oxidative activity. Med Sci Sports Exerc 27 (1995) 536-542
14. Petersen A.M., and Pedersen B.K. The role of IL-6 in mediating the anti-inflammatory effects of exercise. J Physiol Pharmacol 57 Suppl 10 (2006) 43-51
15. Pedersen B.K. The anti-inflammatory effect of exercise: its role in diabetes and cardiovascular disease control. Essays Biochem Rev 42 (2006) 105-117
16. Plomgaard P., Bouzakri K., Krogh-Madsen R., Mittendorfer B., Zierath J.R., and Pedersen B.K. Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation. Diabetes 54 (2005) 2939-2945
17. Northoff H., and Berg A. Immunologic mediators as parameters of the reaction to strenuous exercise. Int J Sports Med 12 1 (1991) S9-S15
18. Bruunsgaard H., Galbo H., Halkjaer-Kristensen J., Johansen T.L., MacLean D.A., and Pedersen B.K. Induced increase in serum interleukin-6 in humans is related to muscle damage. J Physiol 499 (1997) 833-841
19. Ullum H., Haahr P.M., Diamant M., Palmo J., Halkjaer-Kristensen J., and Pedersen B.K. Bicycle exercise enhances plasma IL-6 but does not change IL-1 alpha, IL-1 beta, IL-6, or TNF-alpha pre-mRNA in BMNC. J Appl Physiol 77 (1994) 93-97
20. Rohde T., MacLean D.A., Richter E.A., Kiens B., and Pedersen B.K. Prolonged submaximal eccentric exercise is associated with increased levels of plasma IL-6. Am J Physiol Endocrinol Metab 273 (1997) E85-E91
21. Pedersen B.K., Steensberg A., Fischer C., Keller C., Keller P., Plomgaard P., et al. The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor?. Proc Nutr Soc 63 (2004) 263-267
22. Cihat Y., Yesim Kurtais G., and Peyman Y. Effect of aerobic exercise training on the levels of i{dotless}nterleukin-1b, i{dotless}nterleukin-6 and tumor necrosis factor-a in patients with rheumatoid arthritis. Turkiye Fiziksel Ti{dotless}p ve Rehabilitasyon Dergisi 50 (2004) 3-8
23. Petersen A.M., and Pedersen B.K. The anti-inflammatory effect of exercise. J Appl Physiol. 98 (2005) 1154-1162
24. Pedersen B.K., Steensberg A., Fischer C., Keller C Keller P., Plomgaard P., et al. Searching for the exercise factor: is IL-6 a candidate?. J Muscle Res Cell Motil 24 2-3 (2003) 113-119
25. Fischer C.P., Peter P., Hansen A.K., Henriette P., Saltin B., and Pedersen B.K. Endurance training reduces the contraction-induced interleukin-6 mRNA expression in human skeletal muscle. Am J Physiol Endocrinol Metab 287 (2004) E1189-E1194
26. Smith L.L. Cytokine hypothesis of overtraining: a physiological adaptation to excessive stress?. Med Sci Sports Exerc 32 2 (2000) 317-331
27. Kenneth O., Thomas R., Sven A., Peter S., and Pedersen B.K. Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans. J Physiol 515 (1999) 287-291
28. Arend W.P. Gabay C-cytokines in the rheumatic diseases. Rheum Dis Clin North Am 30 (2004) 41-67 v-vi
29. Brudge G.C. Calder PC-Plasma cytokine response during the postprandial period: a potential causal process in vascular disease?. Br J Nutr 93 (2005) 3-9