Studies on isocyanides: synthesis of tetrazolyl-isoindolinones via tandem Ugi four-component condensation/intramolecular amidation

Tetrahedron Letters

Volumn 49, Issue 1, 2008, Pages 149-152

  Marcos, Carlos F ^a   Marcaccini, Stefano ^b   Menchi, Gloria ^b   Pepino, Roberto ^b   Torroba, Tomás ^c  

^a UNIVERSITY OF EXTREMADURA   (Spain)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF BURGOS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 CHLORO)BENZYL 3 (1 CYCLOHEXYL 1H TETRAZOL) 5 YL 2,3 DIHYDRO 1H ISOINDOL 1 ONE; 3 (1 BENZYL 1H TETRAZOL) 5 YL 2,3 DIHYDRO 2 (4 METHYL)PHENYL 1H ISOINDOL 1 ONE; 3 [1 (4 ETHOXY)PHENYL 1H TETRAZOL] 5 YL 2,3 DIHYDRO 2 METHYL 1H ISOINDOL 1 ONE; 4 CHLOROBENZYLAMINE; 4 TOLUIDINE; ANILINE DERIVATIVE; AZIDE; BENZOIC ACID DERIVATIVE; CYANIDE; ETHOXIDE SODIUM; ISOINDOLE DERIVATIVE; METHYL 2 [(1 BENZYL 1H TETRAZOL) 5 YL (4 METHYLPHENYL)AMINO]METHYLBENZOATE; METHYLAMINE; SODIUM DERIVATIVE; TRIMETHYLSILYLAZIDE; UNCLASSIFIED DRUG;

AMIDATION; ARTICLE; CYCLIZATION; DRUG SYNTHESIS; POLYMERIZATION;

EID: 36549070069     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2007.10.154     Document Type: Article

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42. 2: C, 69.72; H, 5.61; N, 16.94. Found: C, 69.89; H, 5.51; N, 17.03. Ugi adducts 5b-d were prepared in the same manner.
43. 2: C, 64.47; H, 5.11; N, 20.88. Found: C, 64.29; H, 5.21; N, 21.05.
44. 5O: C, 72.42; H, 5.02; N, 18.36. Found: C, 72.46; H, 4.90; N, 18.59. Compounds 6b-d were prepared in a similar manner.