Involvement of mPOU (Brn-5), a class VI POU protein, in the gene expression of Pit-1 as well as PRL

Molecular and Cellular Endocrinology

Volumn 280, Issue 1-2, 2008, Pages 20-29

  Toda, Keizo ^a   Yamamoto, Daisuke ^a   Fumoto, Mariko ^b   Ikeshita, Nobuko ^a   Herningtyas, Elizabeth Henny ^b   Iida, Keiji ^b   Takahashi, Yutaka ^b   Kaji, Hidesuke ^c   Chihara, Kazuo ^b   Okimura, Yasuhiko ^a  

^a KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Neurology and Hematology/Oncology   (Japan)

^c UNIVERSITY OF HYOGO   (Japan)

Author keywords

Brn 5; mPOU; Pit 1; PRL; RNAi

Indexed keywords

DNA; GENOMIC DNA; PROLACTIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BRN 5; TRANSCRIPTION FACTOR PIT 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DNA DETERMINATION; DNA MICROARRAY; EMBRYO; EXPRESSION VECTOR; GENE EXPRESSION; GENETIC TRANSFECTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; NONHUMAN; ORTHOLOGY; PRIORITY JOURNAL; PROLACTIN SECRETING CELL; PROMOTER REGION; PROTEIN CONTENT; PROTEIN FUNCTION; RAT; REDUCTION; REPORTER GENE; RNA INTERFERENCE; RNA SPLICING;

ALTERNATIVE SPLICING; ANIMALS; CELL LINE; CREB-BINDING PROTEIN; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; LACTOTROPHS; PITUITARY GLAND; POU DOMAIN FACTORS; PROLACTIN; PROMOTER REGIONS (GENETICS); RATS; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSCRIPTION FACTOR PIT-1; TRANSFECTION;

EID: 36549003543     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2007.09.002     Document Type: Article

References (33)

1. Andersen B., Schonemann M.D., Pearse R.V., Jenne K., Sugarman J., and Rosenfeld M.G. Brn-5 is a divergent POU domain factor highly expressed in layer IV of the neocortex. J. Biol. Chem. 268 (1993) 23390-23398
2. Biosystems, A. User's Bulliten #2, ABI Prism 7700 Sequence Detection System, 2001.
3. Bach I., Rhodes S.J., Pearse R.V., Heinzel T., Gloss B., Scully K.M., Sawchenko P.E., and Rosenfeld M.G. P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1. Proc. Natl. Acad. Sci. U S A. 92 (1995) 2720-2724
4. Bodner M., Castrillo J.L., Theill L.E., Deerinck T., Ellisman M., and Karin M. The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein. Cell 55 (1988) 505-518
5. Bradford A.P., Conrad K.E., Wasylyk C., Wasylyk B., and Gutierrez-Hartmann A. Functional interaction of c-Ets-1 and GHF-1/Pit-1 mediates Ras activation of pituitary-specific gene expression: mapping of the essential c-Ets-1 domain. Mol. Cell. Biol. 15 (1995) 2849-2857
6. Camper S.A., Saunders T.L., Katz R.W., and Reeves R.H. The Pit-1 transcription factor gene is a candidate for the murine Snell dwarf mutation. Genomics 8 (1990) 586-590
7. Chen R.P., Ingraham H.A., Treacy M.N., Albert V.R., Wilson L., and Rosenfeld M.G. Autoregulation of pit-1 gene expression mediated by two cis-active promoter elements. Nature 346 (1990) 583-586
8. Day R.N., Koike S., Sakai M., Muramatsu M., and Maurer R.A. Both Pit-1 and the estrogen receptor are required for estrogen responsiveness of the rat prolactin gene. Mol. Endocrinol. 4 (1990) 1964-1971
9. d'Emden M.C., Okimura Y., and Maurer R.A. Analysis of functional cooperativity between individual transcription-stimulating elements in the proximal region of the rat prolactin gene. Mol. Endocrinol. 6 (1992) 581-588
10. Fliss M.S., Hinkle P.M., and Bancroft C. Expression cloning and characterization of PREB (prolactin regulatory element binding), a novel WD motif DNA-binding protein with a capacity to regulate prolactin promoter activity. Mol. Endocrinol. 13 (1999) 644-657
11. Fumoto M., Okimura Y., Sakagami Y., Iguchi G., Kishimoto M., Takahashi Y., Kaji H., and Chihara K. Cloning of a protein binding to the most proximal Pit-1 binding element of prolactin gene from human pituitary cDNA library. Mol. Cell. Endocrinol. 207 (2003) 31-38
12. Gage P.J., and Camper S.A. Pituitary homeobox 2, a novel member of the bicoid-related family of homeobox genes, is a potential regulator of anterior structure formation. Hum. Mol. Genet. 6 (1997) 457-464
13. Iguchi G., Okimura Y., Takahashi T., Mizuno I., Fumoto M., Takahashi Y., Kaji H., Abe H., and Chihara K. Cloning and characterization of the 5′-flanking region of the human growth hormone-releasing hormone receptor gene. J. Biol. Chem. 274 (1999) 12108-12114
14. Ingraham H.A., Chen R.P., Mangalam H.J., Elsholtz H.P., Flynn S.E., Lin C.R., Simmons D.M., Swanson L., and Rosenfeld M.G. A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype. Cell 55 (1988) 519-529
15. Iverson R.A., Day K.H., d'Emden M., Day R.N., and Maurer R.A. Clustered point mutation analysis of the rat prolactin promoter. Mol. Endocrinol. 4 (1990) 1564-1571
16. Jacob K.K., and Stanley F.M. CCAAT/enhancer-binding protein alpha is a physiological regulator of prolactin gene expression. Endocrinology 140 (1999) 4542-4550
17. Jang M.K., Mochizuki K., Zhou M., Jeong H.S., Brady J.N., and Ozato K. The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase 2-dependent transcription. Mol. Cell. 19 (2005) 523-534
18. Johansen T., Moens U., Holm T., Fjose A., and Krauss S. Zebrafish pou(c): a divergent POU family gene ubiquitously expressed during embryogenesis. Nucleic Acids Res. 21 (1993) 475-483
19. Kishimoto M., Okimura Y., Yagita K., Iguchi G., Fumoto M., Iida K., Kaji H., Okamura H., and Chihara K. Novel function of the transactivation domain of a pituitary-specific transcription factor Pit-1. J. Biol. Chem. 277 (2002) 45141-45148
20. Machinis K., Pantel J., Netchine I., Leger J., Camand O.J., Sobrier M.L., Dastot-Le Moal F., Duquesnoy P., Abitbol M., Czernichow P., and Amselem S. Syndromic short stature in patients with a germline mutation in the LIM homeobox LHX4. Am. J. Hum. Genet. 69 (2001) 961-968
21. Molinari S., Relaix F., Lemonnier M., Kirschbaum B., Schafer B., and Buckingham M. A novel complex regulates cardiac actin gene expression through interaction of Emb, a class VI POU domain protein, MEF2D, and the histone transacetylase p300. Mol. Cell. Biol. 24 (2004) 2944-2957
22. Okamoto K., Wakamiya M., Noji S., Koyama E., Taniguchi S., Takemura R., Copeland N.G., Gilbert D.J., Jenkins N.A., and Muramatsu M. A novel class of murine POU gene predominantly expressed in central nervous system. J. Biol. Chem. 268 (1993) 7449-7457
23. Okimura Y., Howard P.W., and Maurer R.A. Pit-1 binding sites mediate transcriptional responses to cyclic adenosine 3′,5′-monophosphate through a mechanism that does not require inducible phosphorylation of Pit-1. Mol. Endocrinol. 8 (1994) 1559-1565
24. Relaix F., Molinari S., Lemonnier M., Schafer B., and Buckingham M. The in vivo form of the murine class VI POU protein Emb is larger than that encoded by previously described transcripts. Gene 333 (2004) 35-46
25. Sakagami Y., Okimura Y., Kondoh T., Iguchi G., Fumoto M., Kuno T., Chihara K., and Kohmura E. Expression of mPOU protein in the human pituitary adenomas, Kobe. J. Med. Sci. 49 (2003) 117-122
26. Sheng H.Z., Zhadanov A.B., Mosinger Jr. B., Fujii T., Bertuzzi S., Grinberg A., Lee E.J., Huang S.P., Mahon K.A., and Westphal H. Specification of pituitary cell lineages by the LIM homeobox gene Lhx3. Science 272 (1996) 1004-1007
27. Steinfelder H.J., Hauser P., Nakayama Y., Radovick S., McClaskey J.H., Taylor T., Weintraub B.D., and Wondisford F.E. Thyrotropin-releasing hormone regulation of human TSHB expression: role of a pituitary-specific transcription factor (Pit-1/GHF-1) and potential interaction with a thyroid hormone-inhibitory element. Proc. Natl. Acad. Sci. U. S. A. 88 (1991) 3130-3134
28. Tatsumi K., Miyai K., Notomi T., Kaibe K., Amino N., Mizuno Y., and Kohno H. Cretinism with combined hormone deficiency caused by a mutation in the PIT1 gene. Nat. Genet. 1 (1992) 56-58
29. Wey E., Lyons G.E., and Schafer B.W. A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues. Eur. J. Biochem. 220 (1994) 753-762
30. Wu W., Cogan J.D., Pfaffle R.W., Dasen J.S., Frisch H., O'Connell S.M., Flynn S.E., Brown M.R., Mullis P.E., Parks J.S., Phillips J.A., and Rosenfeld M.G. Mutations in PROP1 cause familial combined pituitary hormone deficiency. Nat. Genet. 18 (1998) 147-149
31. Wu S.Y., Lee A.Y., Hou S.Y., Kemper J.K., Erdjument-Bromage H., Tempst P., and Chiang C.M. Brd4 links chromatin targeting to HPV transcriptional silencing. Gene Dev. 20 (2006) 2383-2396
32. Yang Z., Yik J.H., Chen R., He N., Jank M.K., Ozato K., and Zhou Q. Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol. Cell. 19 (2005) 535-545
33. Zeng L., and Zhou M.M. Bromodomain: an acetyl-lysine binding domain. FEBS Lett. 513 (2002) 124-128