Recent advances in immunodiagnosis of leprosy

Indian Journal of Leprosy

Volumn 79, Issue 2-3, 2007, Pages 85-106

  Sekar, B ^a  

^a Central Leprosy Teaching and Research Institute India   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; CULTURE FILTRATE PROTEIN 10; EARLY SECRETORY ANTIGENIC TARGET 6; EPITOPE; GAMMA INTERFERON; HEAT SHOCK PROTEIN; LIPOARABINOMANNAN; MYCOBACTERIUM ANTIGEN; MYCOBACTERIUM LEPRAE CELL WALL ANTIGEN; MYCOBACTERIUM LEPRAE SOLUBLE ANTIGEN; PHENOLIC GLYCOLIPID I; RECOMBINANT ANTIGEN; UNCLASSIFIED DRUG;

ANTIGEN DETECTION; CLINICAL TRIAL; CROSS REACTION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE SEQUENCE; HUMAN; IMMUNE RESPONSE; INFECTION RISK; LEPROMIN TEST; LEPROSY; MYCOBACTERIUM BOVIS; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; REVIEW; SENSITIVITY AND SPECIFICITY; SERODIAGNOSIS; SKIN TEST; TUBERCULOSIS;

ANTIGENS, BACTERIAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES, T-LYMPHOCYTE; HUMANS; LEPROSY; SEROLOGIC TESTS; SKIN TESTS;

EID: 36448997443     PISSN: 02549395     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (78)

1. Andersen P, Andersen AB, Sorensen AL, et al (1995). Recall of long-lived immunity to Mycobacterium tuberculosis infection in mice. J Immunol 154: 3359-72
2. Araoz R, Honore N, Cho S, et al (2006). Antigen discovery: a post-genomic approach to leprosy diagnosis. Infect Immun 74: 175-82
3. Aseffa A, Brennan PJ, Dockrell HM, et al (2005). Report on the first meeting of the IDEAL (Initiative for Diagnostic and Epidemiological Assays for Leprosy) Consortium held at Armauer Hansen Research Institute, ALERT, Addis Ababa, Ethiopia on 24-27 October 2004. Lepr Rev 76: 147-59
4. Bach MA, Wallach D, Flageul B, et al (1986). Antibodies to phenolic glycolipid-1 and to whole Mycobacterium leprae in leprosy patients: evolution during therapy. Int J Lepr Other Mycobact Dis 54: 256-67
5. Bagshawe AK, Garsia RJ, Baumgart K, et al (1990). IgM serum antibodies to phenolic glycolipid-1 and clinical leprosy: two years' observation in a community with hyperendemic leprosy. Int J Lepr Other Mycobact Dis 58: 25-30
6. Berthet FX, Rasmussen I, Rosenkrands P, et al (1998). A Mycobacterium tuberculosis operon encoding ESAT-6 and a novel low-molecular-mass culture filtrate protein (CFP 10). Microbiology (Pt II) 144:3195-203
7. Brahmbhatt S, Hussian R, Zafar S, et al (2002). Human T-cell responses to peptides of the Mycobacterium leprae 45 kDa serine-rich antigen. Clin Exp Immunol 128: 140-8
8. Brennan PJ (2000). Skin test development in leprosy: progress with first-generation skin test antigens, and an approach to the second generation. Workshop proceedings of leprosy research at new millennium, Paris, 26-28 June 2000. Lepr Rev 71 (Suppl): S50-4
9. Brennan PJ, TerLouw SM (1998). New skin antigens for the diagnosis of leprosy. Transactions of the 19th International Leprosy Congress. Int J Lepr Other Mycobact Dis 66: 96A (abstract).
10. Britton WJ, Lockwood DN (2004). Leprosy. Lancet 363 (9416): 1209-19
11. Brosch R, Gordon SV, Eiglmeier K, et al (2000). Comparative genomics of the leprosy and tubercle bacilli. Res Microbiol 151: 135-42
12. Buhrer-Sekula S, Cunha MG, Ferreira, WA, et al (1998). The use of whole blood in a dipstick assay for the detection of antibodies to Mycobacterium leprae: a field evaluation. FEMS Immunol Med Microbiol 21: 197-201
13. Buhrer-Sekula S, Sarno EN, Oskam L, et al (2000). Use of ML dipstick as a tool to classify leprosy patients. Int J Lepr Other Mycobact Dis 68: 456-63
14. Buhrer-Sekula S, Smits HL, Gussenhoven GC, et al (1998). A simple dipstick assay for the detection of antibodies to phenolic glycolipid-1 of Mycobacterium leprae. Am J Trop Med Hyg. 58: 133-6
15. Buhrer-Sekula S, Smits HL, Gussenhoven GC, et al (2003). Simple and fast lateral flow test for classification of leprosy patients and identification of contacts with high risk of developing leprosy. J Clin Microbiol 41: 1991-5
16. Caruso AMN, Serbina N, Klein K, et al (1999). Mice deficient in CD4 T-cells have only transiently diminished levels of IFN-γ yet succumb to tuberculosis. J Immunol 162: 5407-16
17. Cellona RV, Walsh GP, Fajardo TT, et al (1993). Cross-sectional assessment of ELISA reactivity in leprosy patients, contacts and normal population using the semi-synthetic antigen natural disaccharide octyl bovine serum albumin (ND-O-BSA) in Cebu, the Philippines. Int J Lepr Other Mycobact Dis 61: 192-8
18. Chanteau S, Cartel JL, Boutin JP, et al (1991). Evaluation of gelatin particle agglutination assay for the detection of anti-PGL-1 antibodies. Comparison with ELISA method and applicability on a large scale study using blood collected on filter paper. Lepr Rev 62: 255-61
19. Chanteau 5, Cartel JL, Celerier P, et al (1989). PGL-1 antigen and antibody detection in leprosy patients: evolution under chemotherapy. Int J Lepr Other Mycobact Dis 57: 735-43
20. Chanteau S, Cartel JL, Roux J, et al (1988). Comparison of synthetic antigens for detecting of antibodies to phenolic glycolipid 1 in patients with leprosy and their contacts. J Infect Dis 157: 770-6
21. Cho SN, Yanagihara DL, Hunter SW, et al (1983). Serological specificity of phenolic glycolipid-1 from Mycobacterium leprae and use in serodiagnosis of leprosy. Infect Immun 43: 1077-83
22. Chua-Intra B, Ivanyi J, Hills A, et al (1998a). Predominant recognition of species-specific determinants of the GrosES homologues from Mycobacterium leprae and M. tuberculosis. Immunol 93: 64-72
23. Chua-Intra B, Peerapakorn S, Davey N, et al (1998b). T-cell recognition of mycobacterial GrosES peptide in Thai leprosy patients and contacts. Infect Immun 66: 4903-9
24. Chua-Intra B, Wattanapokayakit 5, Srisungngam S, et al (2003). T-cell recognition of peptides from Mycobacterium leprae 35kDa protein in Thai leprosy patients, healthy contacts, and non-contacts. (Letter) Immunol 88: 71-6
25. Cole ST, Brosch R, Parkhill J, et al (1998). Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393: 537-44
26. Cole ST, Eiglmeier K, Parkhill J, et al (2001). Massive gene decay in the leprosy bacillus. Nature 409 (6823): 1007-11
27. Cooper, AM, Dalton DK, Stewart TA, et al (1993). Disseminated tuberculosis in intefferon-gamma-gene disrupted mice. J Exp Med 178: 2243-7
28. Cunanan Jr A, Chan GP, Douglas JT (1998). Risk of developing leprosy among contacts. Int J Lepr Other Mycobact Dis 61: 78A
29. Dharmendra (1942). Studies of the lepromin test. (9) A bacillary antigen standardization by weight. Lepr India 14:122-9
30. Dharmendra, Chatterjee KR (1955). Prognostic value of lepromin test in contacts of leprosy cases. Lepr India 27: 149-52
31. Dockrell HM, Brahmbhatt S, Robertson BD, et al (2000). A post-genomic approach to identification of Mycobacterium leprae-specific peptides as T-cell reagents. Infect Immun. 68: 5846-55
32. Fine PE, Ponnighaus JM, Burgess P, et al (1988). Sero-epidemiological studies of leprosy in northern Malawi based on an enzyme-linked immunosorbent assay using synthetic glycoconjucate antigen. Int J Lepr Other Mycobact Dis 56: 243-54
33. Fujiwara T, Aspinall GO, Hunter SW, et al (1987). Chemical synthesis of the trisaccharide unit of the species-specific phenolic glycolipid from Mycobacterium leprae. Carbohydr Res 163: 41-52
34. Geluk A, Klein MR, Franken KL, et al (2005). Post-genomic approach to identify novel Mycobacterium leprae antigens with potential to improve immunodiagnosis of infection. Infect Immun 73: 5636-44
35. Geluk A, van Meijgaarden KE, Franken KL, et al (2002). Identification and characterization of the ESAT-6 homologue of Mycobacterium leprae and T-cell cross-reactivity with Mycobacterium tuberculosis. Infect Immun 70: 2544-8
36. Geluk A, van Meijgaarden KE, Franken KL, et al (2004). Immunological cross-reactivity of the Mycobacterium leprae CFP-10 with its homologue in Mycobacterium tuberculosis. Scand J Immunol. 59: 66-70
37. González-Abreu E, Pon JA, Hernandez P, et al (1996). Serological reactivity to a synthetic analog of phenolic glycolipid-1 and early detection of leprosy in an area of low endemicity. Lepr Rev 67: 4-12
38. Gupte MD, Anantharaman DS (1988). Use of soluble antigens in leprosy epidemiology. Lepr Rev 59:329-35
39. Hanks JH, Abe M, Nakayama T, et al (1970). Studies toward the standardization of lepromin. Bull WHO 42: 7
40. Harboe M, Oettinger T, Wilker HG, et al (1996). Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG. Infect Immun 64:16-22
41. Hunter SW, Brennan PJ (1981). A novel phenolic glycolipid from Mycobacterium leprae possibly involved in inimunogenicity and pathogenicity. J Bacteriol 147: 728-35
42. Hunter SW, Rivoire B, Mehra V, et al (1990). The major native proteins of the leprosy bacillus. J Biol Chem 265; 14065-8
43. Hussain R, Jamil S, Kifayet A, et al (1990). Quantitation of IgM antibodies to the M. leprae synthetic disaccharide can predict early bacterial multiplication in leprosy. Int J Lepr Other Mycobact Dis 58: 491-502
44. Ivanyi J, Morris JA, Keen M (1985). Studies with antibodies to mycobacteria. Macairo AJL, Macairo EG (eds.). In: Monoclonal antibodies to bacteria. London: Academic Press. p 51
45. Ivanyi J, Sinha S, Aston R, et al (1983). Definition of species-specific and cross-reactive antigenic determinants of M. leprae using monoclonal antibodies. Clin Exp Immunol 52: 528-36
46. Izumi S, Fujiwara T, Ikeda M, et al (1990). Novel gelatin particle agglutination test for serodiagnosis of leprosy in the field. J Clin Microbiol 28: 525-9
47. Krishnamurthy P, Rao PSS, Reddy BN, et al (1991). Sero-epidemiological study of leprosy in a highly endemic population of South India based on an ELISA using synthetic PGL-1. Int J Lepr Other Mycobact Dis 59: 426-31
48. Maeda Y (2006). Diagnosis of leprosy-serological aspects. Jpn J Leprosy 75: 285-9
49. Mahairas GG, Sabo PJ, Hickey D, et al (1996). Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M bovis. J Bacteriol 178: 1274-82
50. Menzel S, Harboe M, Bergsvik H, et al (1987). Antibodies to a synthetic analog of phenolic glycoloipid-1 of Mycobacterium leprae in healthy household contacts of patients with leprosy. Int J Lepr Other Mycobact Dis 55: 617-25
51. Mitsuda K (1919). On the value of skin reaction to a suspension of leprosy nodules. Jpn J Dermatol Urol 19: 697-708
52. Mohagheghpour N, Munn MW, Gelber RH, et al (1990). Identification of an immuno-stimulating protein from Mycobacterium leprae. Infect Immun 58: 703-10
53. Oskam L, Slim E, Buhrer-Sekula S (2004). Serology: recent developments, strengths, limitations and prospects: A state-of-the-art overview. Lepr Rev 74: 196-205
54. Ottenhoff TH, Klaster PR, Ivanyi J, et al (1986). Mycobacterium leprae-specific protein antigens defined by cloned human helper T-cells. Nature 319: 66-8
55. Prakash O, Kumar A, Nigam A (2006). Detection of antibodies against Mycobacterium leprae culture filtrate protein-10 in leprosy patients. J Med Microbiol 55: 1337-41
56. Rivoire B, Pessolani MCV, Bozic CM, et al (1994). Chemical definition, cloning, and expression of the major protein of the leprosy bacillus. Infect Immun 62: 2417-25
57. Roche PW, Britton WJ, Failbus SS, et al (1990). Operational value of serological measurement in multibacillary leprosy patients: clinical and bacteriological correlates of antibody response. Int J Lepr Other Mycobact Dis 58: 480-90
58. Roche PW, Britton WJ, Failbus SS, et al (1991). Serological responses in primary neuritic leprosy. Trans R Soc Trop Med Hyg 85: 299-302
59. Roche PW, Britton WJ, Failbus SS, et al (1993). Serological monitoring of the responses to chemotherapy in leprosy patients. Int J Lepr Other Mycobact Dis 61: 35-43
60. Saunderson P, Groenen G (2000). Which physical signs help most in the diagnosis of leprosy? A proposal based on experience in the AMFES project, ALERT, Ethiopia. Lepr Rev 72: 34-42
61. Sekar B, Anandan D (1992). Evaluation of Mycobacterium leprae particle agglutination test, using eluates of filter paper blood spots. Lepr Rev 63: 117-24
62. Sengupta U (1999). Recombinant antigen: current situation and future. Int J Lepr Other Mycobact Dis 71: 111-20
63. Sengupta U (2000). Experience and lessons from the use of lepromin and Mycobacterium leprae-specific serology. Workshop proceedings on leprosy research at the new millennium, 26-28 June 2000. Lepr Rev 71 (suppl) S63-6
64. Sinha S, Sengupta U, Ramu G, et al (1983). A serological test for leprosy based on competitive inhibition of monoclonal antibody binding to MY2a determinant of Mycobacterium leprae. Trans R Soc Trop Med Hyg 77: 869-71
65. Snider D (1982). The immunology of tuberculosis. Clin Chest Med 1: 189-201
66. Soebono H, Klaster PR (1991). A sero-epidemiological study of leprosy in high- and low-endemic Indonesian Villages. Int J Lepr Other Mycobact Dis 59: 416-25
67. Spencer JS, Dockrell HM, Kim HJ, et al (2005). Identification of specific proteins and peptides in Mycobacterium leprae suitable for the selective diagnosis of leprosy. J Immunol 175: 7930- 8
68. Spencer JS, Kim HJ, Marques AM, et al (2004). Comparative analysis of B-cell and T-cell epitopes of Mycobacterium leprae and Mycobacterium tuberculosis culture filtrate protein 10. Infect Immun 72: 3161-70
69. Spencer JS, Marques MAM, Lima MCBS, et al (2002). Antigenic specificity of the Mycobacterium leprae homologue of ESAT-6. Infect Immun 70: 1010-3
70. Triccas JA, Roche PA, Winter N, et al (1996). A 35 kDa protein is a major target of the human immune response to Mycobacterium leprae. Infect Immun 64: 5171-7
71. van Beers SM, Izumi S, Madjid B, et al (1994). An epidemiological study of leprosy infection by serology and polymerase chain reaction. Int J Lepr Other Mycobact Dis 62: 1-9
72. Vissa V, Brennan PJ (2001). The genome of Mycobacterium leprae: a minimal mycobacterial gene set. Genome Biol 2: 1-7
73. Winter N, Triccas JA, Rivoire B, et al (1995). Characterization of the gene encoding the immunodominant 35 kDa protein of Mycobacterium leprae. Mol Microbiol 16: 865-76
74. World Health Organization (1985). Vaccination trials against leprosy: Meeting of the Epidemiology Sub-group of Scientific Working Group on the Immunology of Leprosy. Geneva, 11-13 February 1985. Unpublished document TDR/JIMMLEP/EPD/85.3. pp 7-8.
75. World Health Organization. (2003). Leprosy elimination campaigns: impact on case-detection. Wkly Epidemiol Rec 78: 9-16
76. World Health Organization (2006). Global leprosy situation, 2006. Wkly Epidemiol Rec 81:309-16
77. Young RA, Mehra V, Sweetser D, et al (1985). Genes for the major protein antigens of the leprosy parasite Mycobacterium leprae. Nature 316: 450-2
78. Young D, Robertson B (2001). Genomics: leprosy - a degenerative disease of the genome. Curr Biol 11: R381-3