The role of NMDA and non-NMDA receptors in the NTS in mediating three distinct sympathoinhibitory reflexes

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 376, Issue 4, 2007, Pages 241-252

  Sartor, Daniela M ^a,b   Verberne, Anthony J M ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b AUSTIN HEALTH   (Australia)

Author keywords

Excitatory amino acid; Hypotension; Reflex; Sympathetic nervous system

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; AMINO ACID RECEPTOR; AMINO ACID RECEPTOR STIMULATING AGENT; CHOLECYSTOKININ; KYNURENIC ACID; MUSCIMOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHENYLBIGUANIDE; PHENYLEPHRINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; BRADYCARDIA; CONTROLLED STUDY; HEART RATE; MALE; MICROINJECTION; NONHUMAN; PRESSORECEPTOR REFLEX; RAT; RECEPTOR BLOCKING; SOLITARY TRACT NUCLEUS; SPLANCHNIC NERVE; SYMPATHETIC REFLEX; VASOMOTOR REFLEX;

2-AMINO-5-PHOSPHONOVALERATE; ANIMALS; BIGUANIDES; BLOOD PRESSURE; CHOLECYSTOKININ; GABA AGONISTS; HEART RATE; KYNURENIC ACID; MALE; MUSCIMOL; PHENYLEPHRINE; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; RECEPTORS, KAINIC ACID; RECEPTORS, N-METHYL-D-ASPARTATE; REFLEX; SOLITARY NUCLEUS; SYNAPTIC TRANSMISSION;

EID: 36448989319     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-007-0203-5     Document Type: Article

References (47)

1. Alexander SP, Mathie A, Peters JA (2006) Guide to receptors and channels, 2nd edition. Br J Pharmacol 147(Suppl 3):S1-S168
2. Aronow WS, Ahn C (1997) Association of postprandial hypotension with incidence of falls, syncope, coronary events, stroke, and total mortality at 29-month follow-up in 499 older nursing home residents. J Am Geriatr Soc 45:1051-1053
3. Aylwin ML, Horowitz JM, Bonham AC (1997) NMDA receptors contribute to primary visceral afferent transmission in the nucleus of the solitary tract. J Neurophysiol 77:2539-2548
4. Chen CY, Bonham AC (1998) Non-NMDA and NMDA receptors transmit area postrema input to aortic baroreceptor neurons in NTS. Am J Physiol 275:H1695-H1706
5. Chen SY, Wu WC, Tseng CJ, Kuo JS, Chai CY (1997) Involvement of non-NMDA and NMDA receptors in glutamate-induced pressor or depressor responses of the pons and medulla. Clin Exp Pharmacol Physiol 24:46-56
6. Chianca DA, Machado BH (1996) Microinjection of NMDA antagonist into the NTS of conscious rats blocks the Bezold-Jarisch reflex. Brain Res 718:185-188
7. Fisher AA, Davis MW, Le Couteur DG (2005a) The effect of meals at different mealtimes on blood pressure and symptoms in geriatric patients with postprandial hypotension. J Gerontol A Biol Sci Med Sci 60:184-185
8. Fisher AA, Davis MW, Srikusalanukul W, Budge MM (2005b) Postprandial hypotension predicts all-cause mortality in older, low-level care residents. J Am Geriatr Soc 53:1313-1320
9. Gordon FJ (1987) Aortic baroreceptor reflexes are mediated by NMDA receptors in caudal ventrolateral medulla. Am J Physiol 252:R628-R633
10. Gordon FJ, Leone C (1991) Non-NMDA receptors in the nucleus of the tractus solitarius play the predominant role in mediating aortic baroreceptor reflexes. Brain Res 568:319-322
11. Guyenet PG, Darnall RA, Riley TA (1990) Rostral ventrolateral medulla and sympathorespiratory integration in rats. Am J Physiol 259:R1063-R1074
12. Guyenet PG, Filtz TM, Donaldson SR (1987) Role of excitatory amino acids in rat vagal and sympathetic baroreflexes. Brain Res 407:272-284
13. Haibara AS, Colombari E, Chianca DA, Bonagamba LGH, Machado BH (1995) NMDA receptors in NTS are involved in bradycardic but not in pressor response of chemoreflex. Am J Physiol 38:H1421-H1427
14. Jansen RW, Connelly CM, Kelley-Gagnon MM, Parker JA, Lipsitz LA (1995) Postprandial hypotension in elderly patients with unexplained syncope. Arch Intern Med 155:945-952
15. Jeggo RD, Kellett DO, Wang Y, Ramage AG, Jordan D (2005) The role of central 5-HT3 receptors in vagal reflex inputs to neurones in the nucleus tractus solitarius of anaesthetized rats. J Physiol 566:939-953
16. Kubo T, Kihara M (1988) Evidence of N-methyl-D-aspartate receptor-mediated modulation of the aortic baroreceptor reflex in the rat nucleus tractus solitarii. Neurosci Lett 87:69-74
17. Kubo T, Kihara M (1991) Unilateral blockade of excitatory amino acid receptors in the nucleus tractus solitarii produces an inhibition of baroreflexes in rats. N-S Arch Pharmacol 343:317-322
18. Le Couteur DG, Fisher AA, Davis MW, McLean AJ (2003) Postprandial systolic blood pressure responses of older people in residential care: association with risk of falling. Gerontology 49:260-264
19. Leone C, Gordon FJ (1989) Is l-glutamate a neurotransmitter of baroreceptor information in the nucleus of the tractus solitarius? J Pharmacol Exp Ther 250:953-962
20. Lipsitz LA, Nyquist RP Jr, Wei JY, Rowe JW (1983) Postprandial reduction in blood pressure in the elderly. New Eng J Med 309:81-83
21. Machado BH (2001) Neurotransmission of the cardiovascular reflexes in the nucleus tractus solitarii of awake rats. Ann NY Acad Sci 940:179-196
22. Machado BH, Mauad H, Chianca Junior DA, Haibara AS, Colombari E (1997) Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii. Braz J Med Biol Res 30:533-543
23. Maurer MS, Karmally W, Rivadeneira H, Parides MK, Bloomfield DM (2000) Upright posture and postprandial hypotension in elderly persons. Ann Intern Med 133:533-536
24. Miyawaki T, Suzuki S, Minson J, Arnolda L, Chalmers J, Llewellyn-Smith I, Pilowsky P (1997) Role of AMPA/kainate receptors in transmission of the sympathetic baroreflex in rat CVLM. Am J Physiol 272:R800-R812
25. Mobley SC, Mandel DA, Schreihofer AM (2006) Systemic cholecystokinin differentially affects baro-activated GABAergic neurons in rat caudal ventrolateral medulla. J Neurophysiol 96:2760-2768
26. Moreira TS, Sato MA, Takakura AC, Menani JV, Colombari E (2005) Role of pressor mechanisms from the NTS and CVLM in control of arterial pressure. Am J Physiol 289:R1416-R1425
27. Mueller PJ, Foley CM, Vogl HW, Hay M, Hasser EM (2005) Cardiovascular response to a group III mGluR agonist in NTS requires NMDA receptors. Am J Physiol 289:R198-R208
28. Ohta H, Talman WT (1994) Both NMDA and non-NMDA receptors in the NTS participate in the baroreceptor reflex in rats. Am J Physiol 267:R1065-R1070
29. Owens NC, Sartor DM, Verberne AJM (1999) Medial prefrontal cortex depressor response: Role of the solitary tract nucleus in the rat. Neuroscience 89:1331-1346
30. Paton JFR, Li YW, Deuchars J, Kasparov S (2000) Properties of solitary tract neurons receiving inputs from the sub-diaphragmatic vagus nerve. Neuroscience 95:141-153
31. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. Academic, Sydney
32. Saita M, Verberne AJM (2003) Roles for CCK1 and 5-HT3 receptors in the effects of CCK on presympathetic vasomotor neuronal discharge in the rat. Br J Pharmacol 139:415-423
33. Sanchez-Fernandez C, Gonzalez MC, Beart PM, Mercer LD, Ruiz-Gayo M, Fernandez-Alfonso MS (2004) A novel role for cholecystokinin: regulation of mesenteric vascular resistance. Regul Pept 121:145-153
34. Sartor DM, Verberne AJM (2002) Cholecystokinin selectively affects presympathetic vasomotor neurons and sympathetic vasomotor outflow. Am J Physiol 282:R1174-R1184
35. Sartor DM, Verberne AJM (2003) Phenotypic identification of rat rostroventrolateral medullary presympathetic vasomotor neurons inhibited by exogenous cholecystokinin. J Comp Neurol 465:467-479
36. Sartor DM, Verberne AJ (2006) The sympathoinhibitory effects of systemic cholecystokinin are dependent on neurons in the caudal ventrolateral medulla in the rat. Am J Physiol 291:R1390-R1398
37. Sartor DM, Shulkes A, Verberne AJ (2006) An enteric signal regulates putative gastrointestinal presympathetic vasomotor neurons in rats. Am J Physiol 290:R625-R633
38. Schreihofer AM, Sved AF (1992) Nucleus tractus solitarius and control of blood pressure in chronic sinoaortic denervated rats. Am J Physiol 263:R258-R266
39. Talman WT (1989) Kynurenic acid microinjected into the nucleus tractus solitarius of rat blocks the arterial baroreflex but not responses to glutamate. Neurosci Lett 102:247-252
40. Vardhan A, Kachroo A, Sapru HN (1993) Excitatory amino acid receptors in the nucleus tractus solitarius mediate the responses to the stimulation of cardio-pulmonary vagal afferent C fiber endings. Brain Res 618:23-31
41. Verberne AJM, Guyenet PG (1992) Medullary pathway of the Bezold-Jarisch reflex in the rat. Am J Physiol 263:R1195-R1202
42. Verberne AJM, Sartor DM (2004) Cholecystokinin-induced inhibition of presympathetic vasomotor neurons: dependence on sub-diaphragmatic vagal afferents and central NMDA receptors in the rat. Am J Physiol 287:R809-R816
43. Verberne AJM, Costa M, Lewis SJ, Louis WJ, Beart PM (1987) The N-methyl-d-aspartate (NMDA) receptor antagonist MK-801, attenuates the Bezold-Jarisch reflex in the anaesthetized rat. Neuropharmacology 26:1243-1246
44. Verberne AJM, Stornetta RL, Guyenet PG (1999) Properties of C1 and other ventrolateral medullary neurones with hypothalamic projections in the rat. J Physiol Lond 517:477-494
45. Wang JJ, Rong WF, Wang WZ, Zhang L, Yuan WJ (2000) NMDA receptor mechanism involved in arterial baroreflex. Acta Pharmacol Sin 21:617-622
46. Zhang J, Mifflin SW (1998) Differential roles for NMDA and non-NMDA receptor subtypes in baroreceptor afferent integration in the nucleus of the solitary tract of the rat. J Physiol Lond 511:733-745
47. Zhang J, Abdel-Rahman AA (2002) The hypotensive action of rilmenidine is dependent on functional N-methyl-d-aspartate receptor in the rostral ventrolateral medulla of conscious spontaneously hypertensive rats. J Pharmacol Exp Ther 303:204-210