Microinjection of NMDA antagonist into the NTS of conscious rats blocks the Bezold-Jarisch reflex

Brain Research

Volumn 718, Issue 1-2, 1996, Pages 185-188

  Chianca Jr , Deoclécio A ^b   Machado, Benedito H ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b NONE

Author keywords

Amino acid receptor; Bradycardia; C fiber; Cardiopulmonary receptor; Phosphonovaleric acid; Sympatho inhibition

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; METHYLATROPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; BRAIN STEM; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; HEART RATE; HISTOLOGY; INTRACEREBRAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REFLEX;

EID: 0030008787     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00010-8     Document Type: Article

References (19)

1. Chianca-Jr., D.A. and Machado, B.H., The sensitivity of the Bezold-Jarisch reflex is increased in rats with sino-aortic deafferentation, Braz. J. Med. Biol. Res., 27 (1994) 775-781.
2. Chianca-Jr., D.A. and Machado, B.H., Neurotransmission of the Bezold-Jarisch reflex in the nucleus tractus solitarii of rats with sino-aortic deafferentation is altered (Abstract), Hypertension, 25 (1995) 1390.
3. Coleridge, H.M. and Coleridge, J.C.G., Cardiovascular afferents involved in regulation of peripheral vessels, Annu. Rev. Physiol., 42 (1980) 413-427.
4. Colombari, E., Bonagamba, L.G.H. and Machado, B.H., Mechanisms of pressor and bradycardic responses to L-glutamate microinjected into the NTS of conscious rats, Am. J. Physiol., 266 (Regulatory Integrative Comp. Physiol., 35) (1994) R730-R738.
5. Guyenet, P.G., Role of the ventral medulla oblongata in blood pressure regulation. In A.D. Loewy and K.M. Spyer (Eds.), Central Regulation of Autonomic Functions, Oxford University Press, New York, 1990, pp. 145-167.
6. Haybara, A.S., Colombari, E., Chianca-Jr., D.A., Bonagamba, L.G.H. and Machado, B.H., NMDA receptors in the NTS are involved in bradycardic but not in pressor response of the chemoreflex, Am. J. Physiol., 269 (Heart Circ. Physiol., 38) (1995) H1421-H1427.
7. Kalia, M. and Mesulam, M., Brainstem projections of sensory and motor components of the vagus complex in the cat, J. Comp. Neurol., 193 (1980) 435-508.
8. Krayer, O., The history of the Bezold-Jarisch reflex, Naunyn-Schmiedeberg's Arch. Exp. Pathol. Pharmacol., 240 (1961) 361-368.
9. Loewy, A.D. and Spyer, K.M., Vagal preganglionic neurons. In A.D. Loewy and K.M. Spyer (Eds.), Central Regulation of Autonomic Functions, Oxford University Press, New York, 1990, pp. 68-87.
10. Machado, B.H. and Bonagamba, L.G.H., Microinjection of L-glutamate into the nucleus tractus solitarii increases arterial pressure in conscious rats, Brain Res., 576 (1992) 131-138.
11. Michelini, L.C. and Bonagamba, L.G.H., Baroreceptor reflex modulation by vasopressin microinjected into the nucleus tractus solitarii of conscious rats, Hypertension, 11 Suppl. I (1988) I-75-I-79.
12. Paxinos, G. and Watson, C., The Rat Brain in Stereotaxic Coordinates, Academic Press, New York, 1982.
13. Sevoz, C., Nosjean, A., Callera, J.C., Machado, B.H., Hamon, M. and Laguzzi, R., Stimulation of serotonin3 receptors in the nucleus tractus solitarius inhibits the cardiac Bezold-Jarisch reflex response, Am. J. Physiol (in press).
14. Thoren, P., Role of cardiac vagal C-fibers in cardiovascular control, Rev. Physiol. Biochem. Pharmacol., (1979) 1-94.
15. Urbansky, R.W. and Sapru, H.N., Putative neurotransmitter involved in medullary cardiovascular regulation, J. Auton. Nerv. Syst., 25 (1988) 181-193.
16. Vardhan, A., Kachroo, A. and Sapru, H.N., Excitatory amino acid receptors in the nucleus tractus solitarius mediate the responses to the stimulation of cardio-pulmonary vagal afferent C fiber endings, Brain Res., 618 (1993) 23-31.
17. Verberne, A.J.M., Beart, P.M. and Louis, W.J., Excitatory amino acid receptors in the caudal ventrolateral medulla mediate a vagal cardiopulmonary reflex in the rat, Exp. Brain Res., 78 (1989) 185-192.
18. Verberne, A.J.M. and Guyenet, P.G., Medullary pathways of the Bezold-Jarisch reflex in the rat, Am. J. Physiol., 263 (1992) R1195-R1202.
19. Willete, R.N., Gatti, P., Gertner, S.B. and Sapru, H.N., Pulmonary vagal afferent stimulants in conscious rats: opioids and phenyldiguanide, Pharmacol. Biochem. Behav., 17 (1982) 19-23.