Temporal and spatial expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in a rat model of myocardial ischemia with or without reperfusion

Journal of the Formosan Medical Association

Volumn 104, Issue 10, 2005, Pages 707-714

  Lu, Ming Jen ^a   Chang, Hang ^a   Chang, Chih Chuan ^a   Wang, Bao Wei ^a   Shyu, Kou Gi ^a,b  

^a SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Hypoxia inducible factor 1, alpha subunit; Myocardial ischemia; Reperfusion; Vascular Endothelial Growth Factor A

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; VASCULOTROPIN; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; HEART INFARCTION; HEART LEFT VENTRICLE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; NONHUMAN; NORTHERN BLOTTING; PROTEIN EXPRESSION; PROTEIN FOLDING; RAT; WESTERN BLOTTING; ANIMAL; DISEASE MODEL; METABOLISM; REPERFUSION INJURY; WISTAR RAT;

ANIMALS; DISEASE MODELS, ANIMAL; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; MYOCARDIAL REPERFUSION INJURY; RATS; RATS, WISTAR; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33644874334     PISSN: 09296646     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Semenza GL: HIF-1: mediator of physiological and pathological response to hypoxia. J Appl Physiol 2000;88:1474-80.
2. Semenza GL, Wang GL: A nuclear factor induced by hypoxia de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992;12:5447-54.
3. Wang GL, Semenza GL: Characterization of hypoxia-inducible factor 1 and regulaton of DNA binding activity by hypoxia. J Biol Chem 1993;268:21513-8.
4. Semenza GL, Agani F, Booth G, et al: Structural and functional analysis of hypoxia-inducible factor 1. Kidney Int 1997;51:553-5.
5. Jiang BH, Semenza GL, Bauer C, et al: Hypoxia-inducible factor 1 levels vary exponentially over a physiological relevent range of O2 tension. Am J Physiol 1996;271:C1172-80.
6. Huang LE, Arany Z, Livingston DM, et al: Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its a subunit. J Biol Chem 1996;271: 32253-9.
7. Pugh CW, O'Rourke JF, Nagao M, et al: Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit. J Biol Chem 1997;272:11205-14.
8. Isner JM: Tissue responses to ischemia: local and remote responses for preserving perfusion of ischemic muscle. J Clin Invest 2000;106:615-9.
9. Williams RS, Benjamin IJ: Protective responses in the ischemic myocardium. J Clin Invest 2000;106:813-8.
10. Semenza GL: Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor-1. J Clin Invest 2000;106:809-12.
11. Martin C, Yu AY, Jiang BH, et al: Cardiac hypertrophy in chronically anemic fetal sheep: increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1. Am J Obstet Gynecol 1998;178:527-34.
12. Lee SH, Wolf PL, Escudero R, et al: Early expression of angiogenesis factors in acute myocardial ischemia and infarction. N Engl J Med 2000;342:626-33.
13. Semenza GL: Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trend Mol Med 2001;7:345-50.
14. Vincent KA, Shyu KG, Luo Y, et al: Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1α/VP16 hybrid transcription factor. Circulation 2000;102: 2255-61.
15. Shyu KG, Wang MT, Wang BW, et al: Intramyocardial injection of naked DNA encoding HIF-1α/VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat. Cardiovasc Res 2002;54:576-83.
16. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-9.
17. Chun YS, Hyun JY, Kwak YG, et al: Hypoxic activation of the atrial natriuretic peptide gene promoter through direct and indirect actions of hypoxia-inducible factor-1. Biochem J 2003; 370:149-57.
18. Su H, Arakawa-Hoy J, Kan YW: Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart model. Proc Natl Acad Sci USA 2002; 99:9480-5.
19. Marfella R, D'Amico M, Di Fillippo C, et al: Myocardial infarction in diabetic rats: role of hyperglycemia on infarct size and early expression of hypoxia-inducible factor 1. Diabetologia 2002;45: 1172-81.
20. Kawata H, Yoshida KI, Kawamoto A, et al: Ischemic preconditioning upregulates vascular endothelial growth factor mRNA expression and neovascularization via nuclear translocation of protein kinase C epsilon in the rat ischemic myocardium. Circ Res 2001;88:696-704.
21. Shweiki D, Itin A, Soffer D, et al: Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992;359:843-5.
22. Shweiki D, Itin A, Neufeld H, et al: Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis. J Clin Invest 1993;91:2235-43.
23. Harada K, Friedman M, Lopez JJ, et al: Vascular endothelial growth factor in chronic myocardial ischemia. Am J Physiol 1996; 270:H1791-802.
24. Bergeron M, Yu AY, Solway KE, et al: Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischemia in rat brain. Eur J Neurosci 1999;11:4159-70.
25. Jin KL, Mao XO, Nagayama T, et al: Induction of vascular endothelial growth factor and hypoxia-inducible factor-1α by global ischemia in rat brain. Neuroscience 2000;99:577-85.
26. Mizukami Y, Li J, Zhang X, et al: Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Cancer Res 2004;64:1765-72.
27. Pore N, Liu S, Shu HK, et al: Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism. Mol Biol Cell 2004;15:4841-53.
28. Yancopoulos GD, Davis S, Gale NW, et al: Vascular-specific growth factors and blood vessel formation. Nature 2000;407:242-8.