Dehydroepiandrosterone: A modulator of cellular immunity and heat shock protein 70 production during polymicrobial sepsis

Intensive Care Medicine

Volumn 33, Issue 12, 2007, Pages 2207-2213

  Oberbeck, Reiner ^a   Deckert, Hanno ^a   Bangen, Jörg ^a   Kobbe, Phillip ^b   Schmitz, Daniel ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Dehydroepiandrosterone; Heat shock protein; Immune function; Sepsis

Indexed keywords

HEAT SHOCK PROTEIN 70; IMMUNOMODULATING AGENT; PRASTERONE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD LEVEL; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; MALE; MOUSE; NONHUMAN; POLYMICROBIAL SEPSIS; SEPSIS; SPLEEN CELL; SURVIVAL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; DEHYDROEPIANDROSTERONE; HSP70 HEAT-SHOCK PROTEINS; IMMUNITY, CELLULAR; MALE; MICE; MICE, INBRED STRAINS; RANDOM ALLOCATION; SEPSIS; SURVIVAL ANALYSIS;

EID: 36448981391     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-007-0851-4     Document Type: Article

References (53)

1. Loria RM, Padgett DA (1992) Androstenediol regulates systemic resistance against lethal viral infections in mice. Arch Virol 127:103-114
2. Ben-Nathan D, Padgett DA, Loria RM (1999) Androstendiol and dehydroepiandrosterone protect mice against lethal bacterial infection and lipopolysaccaride toxicity. J Med Microbiol 48:425-434
3. Padgett DA, Loria RM, Sheridan JF (1997) Endocrine regulation of the immune response to influenza virus infection with a metabolite of DHEA - androstenediol. J Neuroimmunol 78:203-214
4. Oberbeck R, Dahlweid M, Koch M, van Griensven M, Emmendörfer A, Tscherne H, Pape HC (2001) Dehydroepiandrosterone decreases mortality and improves cellular immune function during polymicrobial sepsis. Crit Care Med 29:380-384
5. Sakakura Y, Nakagawa Y, Ohzeki T (2006) Differential effect of DHEA on mitogen-induced proliferation of T and B lymphocytes. J Steroid Biochem Mol Biol 99:115-120
6. Powell JM, Sonnenfeld G (2006) The effects of dehydroepiandrosterone (DHEA) on in vitro spleen cell proliferation and cytokine production. J Interferon Cytokine Res 26:34-39
7. Suzuki T, Shimizu T, Szalay L, Choudry MA, Rue LW 3rd, Bland KI, Chaudry IH (2006) Androstenediol ameliorates alterations in immune cells cytokine production capacity in a two-hit model of trauma-hemorrhage and sepsis. Cytokine 34:76-84
8. Angele MK, Catania RA, Ayala A, Cioffi WG, Bland KI, Chaudry IH (1998) Dehydroepiandrosterone: an inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-hemorrhage. Arch Surg 133:1281-1288
9. Dannenberg HD, Alpert G, Lustig S, Ben-Nathan D (1992) Dehydroepiandrosterone protects mice from endotoxin toxicity and reduces tumor necrosis factor production. Antimicrob Agents Chemother 36:2275-2279
10. Griensven M van, Dahlweid FM, Giannoudis PV, Wittwer T, Böttcher F, Breddin M, Pape HC (2002) Dehydroepiandrosterone modulates the activity and the expression of lymphocyte subpopulations induced by cecal ligation and puncture. Shock 18:445-449
11. Oberbeck R, Nickel E, van Griensven M, Tschernig T, Wittwer T, Schmitz D, Pape HC (2002) The effect of dehydroepiandrosterone on hemorrhage-induced suppression of cellular immune functions. Intensive Care Med 28:963-968
12. Hildebrand F, Pape HC, Hoevel P, Krettek C, van Griensven M (2003) The importance of cytokines in the pathogenesis of polymicrobial sepsis and dehydroepiandrosterone treatment in a rodent model. Shock 20:338-346
13. Kiang JG, Tsokos GC (1998) Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology. Pharmacol Ther 80:183-201
14. Voss MR, Stallone JN, Li M, Cornelussen RNM, Knuefermann P, Knowlton AA (2003) Gender differences in the expression of heat shock proteins: the effect of estrogen. Am J Physiol 285:H687-H692
15. Schroeder S, Bischoff J, Lehmann LE, Hering R, von Spiegel T, Putensen C, Hoeft A, Stüber F (1999) Endotoxin inhibits heat shock protein 70 expression in peripheral blood mononuclear cells of patients with severe sepsis. Intensive Care Med 25:52-57
16. Morikawa A, Kato T, Sugiyama N, Koide N, Yokochi T (1998) Altered expression of constitutive and inducible type heat shock proteins in response to D-galactosamine-sensitized mice to lipopolysaccaride as an experimental endotoxic shock model. FEMS Immunol Med Microbiol 21:37-45
17. Da-Zhong X, Qi L, Gregory M, Deitch E (1996) Effect of heat shock and endotoxin stress on enterocyte viability apoptosis and function varies based on whether the cells are exposed to heat shock or endotoxin first. Arch Surg 131:1222-1228
18. Jäättelä M (1999) Heat shock proteins as cellular lifeguards. Ann Med 31:261-271
19. Jarrar D, Chaudry IH, Wang P (1999) Organ dysfunction following hemorrhage and sepsis: mechanisms and therapeutic approaches. Int J Mol Med 4:575-583
20. Koh Y, Lim CM, Kim MJ, Shim TS, Lee SD (1999) Heat shock response decreases endotoxin-induced acute lung injury in rats. Respirology 4:325-330
21. Singleton KD, Serkova N, Beckey VE, Wischmeyer E (2005) Glutamine attenuates lung injury and improves survival after sepsis: role of enhanced heat shock protein expression. Crit Care Med 33:1206-1213
22. Tang P, Gannon MJ, Andrew A, Miller D (1995) Evidence of estrogenic regulation of heat shock protein expression in human endometrium and steroid-responsive cell lines. Eur J Endoncrinol 133:598-605
23. Voss MR, Stallone JN, Li M, Cornelussen RN, Knuefermann P, Knowlton AA (2003) Gender differences in the expression of heat shock proteins: the effect of estrogens. Am J Physiol 285:H687-H692
24. Heufelder AE, Wenzel BE, Bahn RS (1993) Glucocorticoids modulate the synthesis and expression of a 72 kDa heat shock protein in cultured Graves'retroocular fibroblasts. Acta Endocrinol (Copenh) 128:41-50
25. Svec F, Porter JR (1998) The actions of exogenous dehydroepiandrosterone in experimental animals and humans. Proc Soc Exp Biol Med 218:174-191
26. Baker CC, Chaudry IH, Gaines HO, Baue AE (1983) Evaluation of factors affecting mortality rate after sepsis in murine cecal ligation and puncture model. Surgery 94:331-342
27. Exton MS, v. Hörsten S, Schulte M, Vöge J, Strubel T, Donath S, Nagel E, Westermann J, Schedlowski M (1988) Behaviourally conditioned immunosupression using cyclosporine A. J Neuroimmunol 88:182-191
28. Fleshner M, Nguyen KT, Cotter CS, Watkins LR, Maier SF (1998) Acute stressor suppresses acquired immunity and potentiates innate immunity. Am J Physiol 275:R870-R878
29. Oberbeck R (2004) Therapeutic implications of immune endocrine interactions in the critically ill patients. Curr Drug Targets 4:129-139
30. Catania RA, Angele MK, Ayala A, Cioffi WG, Bland KI, Chaudry IH (1999) Dheydroepiandrosterone restored immune function following trauma hemorrhage by a direct effect on T-lymphocytes. Cytokine 11:443-450
31. Blauer KL, Poth M, Roger WM, Bernton EW (1991) Dehydroepiandrosterone antagonizes the suppressive effects of dexamethasone on lymphocyte proliferation. Endocrinology 129:3174-3179
32. Jarrar D, Kuebler JF, Wang P, Bland KI, Chaudry IH (2001) DHEA: a novel adjunct for the treatment of male trauma patients. Trends Mol Med 7:81-85
33. Cohen JJ (1993) Apoptosis. Immunol Today 14:126-130
34. Takabashi H, Nakajima A, Sekihara A (2004) Dehydroepiandrosterone (DHEA) and its sulphate (DHEAS) inhibit the apoptosis in human peripheral blood lymphocytes. J Steroid Biochem Mol Biol 88:261-268
35. Hampl R, Vondra K (2006) Natural antiglucocorticoids. Vnitr Lek 52:973-978
36. Blauer KL, Poth M, Rogers WM, Bernton EW (1991) DHEA antagonizes the suppressive effects of dexamethasone on lymphocyte proliferation. Endocrinology 129:3174-3179
37. Browne ES, Wright BE, Porter JR, Svec F (1992) DHEA: antiglucocorticoid action in mice. Am J Med Sci 303:366-371
38. Williams JR (2000) The effects of DHEA on carcinogenesis, obesity, the immune system, and aging. Lipids 35:325-331
39. Herr I, Gassler N, Friess H, Büchler MW (2007) Regulation of differential pro- and anti-apoptotic signaling by glucocorticoids. Apoptosis 12:271-291
40. Szalay L, Shimizu T, Suzuki T, Hseih YH, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH (2006) Androstenediol administration after trauma-hemorrhage attenuates inflammatory response, reduces organ damage, and improves survival following sepsis. Am J Physiol 291:G260-G266
41. Jarrar D, Wang P, Cioffi WG, Bland KI, Chaudry IH (2000) Mechanisms of salutary effects of dehydroepiandrosterone after trauma-hemorrhage: direct or indirect effects on cardiac and hepatocellular function. Arch Surg 135:416-422
42. Singleton KD, Serkova N, Beckey VE, Wischmeyer PE (2005) Glutamine attenuates lung injury and improves survival of sepsis: role of enhanced heat shock protein expression. Crit Care Med 33:1206-1213
43. Villar J, Ribeiro SP, Brendan J, Mulen M, Post M, Slutsky A (1994) Induction of the heat shock response reduces the mortality rate and organ damage in a sepsis-induced acute lung injury model. Crit Care Med 22:914-921
44. Hotchkiss R, Nunnally I, Lindquist S, Taulien J, Perdrizet G, Karl I (1993) Hyperthermia protects mice against the lethal effects of endotoxin. Am J Physiol 265:R1447-R1457
45. Ribeiro SP, Villar J, Downey GP, Edelson JD, Slutsky AS (1994) Sodium arsenite induces heat shock protein-72 kilodalton expression in the lungs and protects rats against sepsis. Crit Care Med 22:922-929
46. Ryan AJ, Flanagan SW, Moseley PL, Gisolfi CV (1992) Acute heat stress protects rats against endotoxin shock. J Appl Physiol 73:1517-1522
47. Bruemmer-Smith S, Stüber F, Schroeder S (2001) Protective functions of intracellular heat-shock protein (HSP) 70-expression in patients with severe sepsis. Intensive Care Med 27:1835-1841
48. DeMaio A (1999) Heat shock proteins: facts, thoughts, and dreams. Shock 11:1-12
49. Chen D, Pan J, Du B, Sun D (2005) Induction of the heat shock response in vivo inhibits NF-kappa B activity and protects murine liver from endotoxemia-induced injury. J Clin Immunol 25:452-461
50. Ostberg JR, Kaplan KC, Repasky EA (2002) Induction of stress proteins in a panel of mouse tissues by fever-range whole body hyperthermia. Int J Hyperthermia 18:552-562
51. Ofenstein JP, Heidemann S, Juett-Wilstermann A, Sarnaik A (2000) Expression of stress proteins HSP 72 & HSP 32 in response to endotoxemia. Ann Clin Lab Sci 30:92-98
52. Flohé S, Dominguez Fernandez E, Ackermann M, Hirsch T, Borgermann J, Schade FU (1999) Endotoxin tolerance in rats: expression of TNF-α, IL-6, IL-10, VCAM, and HSP 70 in lung and liver during endotoxin shock. Cytokine 11:796-804
53. Shi Y, Tu Z, Tang D, Liu M, Wang K, Calderwood S, Xiao X (2006) The inhibition of LPS-induced production of the inflammatory cytokines by HSP 70 involves inactivation of the NF-kappa B pathway but not the MAPK pathways. Shock 26:277-284