Structural insights into the amino-terminus of the secretin receptor: I. Status of cysteine and cystine residues

Molecular Pharmacology

Volumn 58, Issue 5, 2000, Pages 911-919

  Asmann, Yan W ^a   Dong, Maoqing ^a   Ganguli, Subhas ^a   Hadac, Elizabeth M ^a   Miller, Laurence J ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ASPARTIC ACID; CARBON 14; CYSTEINE; CYSTINE; G PROTEIN COUPLED RECEPTOR; IODOACETAMIDE; PROLINE; REDUCING AGENT; SECRETIN; SECRETIN RECEPTOR; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; COVALENT BOND; DISULFIDE BOND; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; REDUCTION; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

EID: 0033784976     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.58.5.911     Document Type: Article

References (38)

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3. The amino-terminal fragment of the adenylate cyclase activating polypeptide (PACAP) receptor functions as a high affinity PACAP binding domain
4. Role of extracellular disulfide-bonded cysteines in the ligand binding function of the beta 2-adrenergic receptor
5. Identification of an interaction between residue 6 of the natural peptide ligand and a distinct residue within the amino-terminal tall of the secretin receptor
6. Demonstration of a direct interaction between residue 22 in the carboxyl-terminal half of secretin and the amino-terminal tail of the secretin receptor using photoaffinity labeling
7. Protean effects of a natural peptide agonist of the G protein-coupled secretin receptor demonstrated by receptor mutagenesis
8. Mutational analysis of cysteine residues within the extracellular domains of the human vasoactive intestinal peptide (VIP) 1 receptor identifies seven mutants that are defective in VIP binding
9. Interaction of Amino acid residues at positions of secretin with the N-terminal domain of the secretin receptor
10. The C-terminus ends of secretin and VIP interact with the N- terminal domains of their receptors
11. Relationship between native and recombinant cholecystoklnin receptors -role of differential glycosylation
12. Direct identification of a second distinct site of contact between cholecystokinin and its receptor
13. Site-directed mutagenesis by overlap extension using polymerase chain reaction
14. Multiple extracellular loop domains contribute critical determinants for agonist binding and activation of the secretin receptor
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22. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
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36. Intrinsic photoaffinity labeling of native and recombinant rat pancreatic secretin receptors
37. Properties of chimeric secretin and VIP receptor proteins indicate the importance of the N-terminal domain for ligand discrimination
38. Mutational analysis of extracellular cysteine residues of rat secretin receptor shows that disulfide bridges are essential for receptor function