Rapid proteasomal degradation of translocation-deficient UDP-glucuronosyltransferase 1A1 proteins in patients with Crigler-Najjar type II

Biochemical and Biophysical Research Communications

Volumn 310, Issue 3, 2003, Pages 735-741

  Ohnishi, Aki ^a   Emi, Yoshikazu ^a  

^a UNIVERSITY OF HYOGO   (Japan)

Author keywords

Crigler Najjar syndrome; Hyperbilirubinemia; Proteasome; Protein degradation; Signal peptide; UDP glucuronosyltransferase

Indexed keywords

ARGININE; BILIRUBIN; GLUCURONOSYLTRANSFERASE; LEUCINE; MUTANT PROTEIN; PROTEASOME; SIGNAL PEPTIDE;

ADULT; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL STRAIN COS1; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CRIGLER NAJJAR SYNDROME; ENDOPLASMIC RETICULUM; FEMALE; GENE DISRUPTION; GENETIC TRANSFECTION; GLUCURONIDATION; HALF LIFE TIME; HUMAN; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; WILD TYPE;

EID: 0141645437     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2003.09.072     Document Type: Article

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