Testosterone, diabetes mellitus, and the metabolic syndrome

Current Urology Reports

Volumn 8, Issue 6, 2007, Pages 467-471

  Spark, Richard F ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; GONADORELIN; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

BLOOD PRESSURE MEASUREMENT; CANCER SURVIVOR; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; DIAGNOSTIC ACCURACY; DIALYSIS; ERECTILE DYSFUNCTION; HUMAN; HYPOGONADISM; KLINEFELTER SYNDROME; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; REVIEW; RISK FACTOR; TESTIS CANCER; TESTOSTERONE BLOOD LEVEL;

ANTILIPEMIC AGENTS; COMORBIDITY; DIABETES MELLITUS, TYPE 2; HUMANS; HYPOGONADISM; INCIDENCE; MALE; METABOLIC SYNDROME X; PROGNOSIS; RISK FACTORS; TESTOSTERONE; TREATMENT OUTCOME;

EID: 36349023156     PISSN: 15272737     EISSN: 15346285     Source Type: Journal    
DOI: 10.1007/s11934-007-0050-4     Document Type: Review

References (24)

1. Laaksonen DE, Niskanen L, Punnonen K, Nyssonen K, et al.: Testosterone and sex hormone binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care 2004, 27:1036-1041 An 11-year study showing that men with lowest testosterone levels are at risk for developing metabolic syndrome in the next decade.
2. Costello AD, Legro RS, Dunaif A: Adolescent girls with polycystic ovary syndrome have an increased prevalence of risk of metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance. J Clin Endocrinol Metab 91:492-497
3. Ehrmann DA, Liljjenllquist DR, Kasza A, et al.: 2006 prevalence of predictors of metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2006, 91:48-53.
4. Muller M, Grobee DE, den Tonkelaar, Lamberts SW, et al.: Endogenous sex hormones and metabolic syndrome in men. J Clin Endocrinol Metab 2005, 90:2618-2623.
5. Tong PC, Ho CS, Teung VT, Ng MC, et al.: Association of testosterone, insulin-like growth factor, and C-reactive protein with metabolic syndrome in Chinese middle-aged men with a family history of type 2 diabetes. J Clin Endocrinol Metab 2005, 90:6418-6423.
6. Corona G, Manucci E, Schulman C, et al.: Psychologic correlates of the metabolic syndrome and associated sexual dysfunction. Eur Urol 2006, 50:595-604.
7. Kupelian V, Page ST, Araujo AB, et al.: Low sex hormone binding globulin, total testosterone, and symptomatic androgen deficiency are associated with the development of the metabolic syndrome in non-obese men. J Clin Endocrinol Metab 2006, 91:843-850. Metabolic syndrome is uncommon in men with high serum testosterone levels
8. Zitzmann E, Faber S, Nieschlag E: Association of specific symptoms and metabolic risks with serum testosterone levels in older men. J Clin Endocrinol Metab 2006, 91:4335-4343.
9. Bojesen A, Kristensen K, Birkebaek NH, et al.: The metabolic syndrome is frequent in men with Klinefelter's syndrome and is associated with abdominal obesity and hypogonadism. Diabetes Care 2006, 29:1591-1598.
10. Braga-Basaria M, Dobs AS, Muller DC, et al.: Metabolic syndrome in men with prostate cancer undergoing long-term androgen deprivation therapy. J Clin Oncol 2006, 24:3979-3983.
11. Nuver J, Smit AJ, Wolffenbuttel BH, et al.: The metabolic syndrome and disturbances in hormone levels in long-term survivors of disseminated testicular cancer. J Clin Oncol 2005, 23:3718-3725.
12. Kaplan SA, Meehan AG, Shah A: The age related decrease in testosterone is significantly exacerbated in obese men with the metabolic syndrome. What are the implications for the relatively high incidence of erectile dysfunction observed in these men? J Urol 2006, 176:1527-1528.
13. Makhsida N, Shah J, Yan G, et al.: Hypogonadism and metabolic syndrome: implications for testosterone therapy. J Urol 2005, 174:827-834.
14. Harman SM, Metter EJ, Tobin JD, et al.: Longitudinal effects of aging on serum total and free testosterone levels in healthy aging men. J Clin Endocrinol Metab 2001, 86:724-731.
15. Vermeulen A, Verdonck L, Kaufman JM: A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999, 84:3666-3672.
16. Murray FT, Wyss HU, Thomas RG, et al.: Gonadal dysfunction in diabetic men with organic impotence. J Clin Endocrinol Metab 1987, 65:127-135.
17. Dhindsa D, Prabhakar S, Sethi M, et al.: Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes. J Clin Endocrinol Metab 2004, 89:5462-5468. One of three men with type 2 diabetes has secondary hypogonadism.
18. Rosner W: An extraordinarily inaccurate assay for free testosterone is still with us. J Clin Endocrinol Metab 2001, 86:2903.
19. Winters SJ, Kelley DE, Goodpaster B: The analog free testosterone assay: are the results in men clinically useful? Cli Chem 1998, 44:2178-2182.
20. Laukkanen JA, Laaksonen DE, Niskanen L, et al.: Metabolic syndrome and the risk of prostate cancer in Finnish men: a population based study. Cancer Epidemiol Biomarkers Prev 2004, 13:1646-1650.
21. Mårdh S, Ljungström O, Högstedt S, Zetterqvist O: Clinical, haemodynamic, anthropometric, metabolic , and insulin profile of men with high grade clinical prostate cancer. Blood Press 2004, 13:47-55.
22. Beebe-Dimmer JL, Dunn RL, Sarma AV, et al.: Features of the metabolic syndrome and prostate cancer in African-American men. Cancer 2007, 109:75-81.
23. Tande AJ, Platz EA, Folsom AR: The metabolic syndrome is associated with a reduced risk of prostate cancer. Am J Epidemiol 2006, 164:1094-1102.
24. Lund Håheim L, Wisløff TF, Holme I, Nafstad P: Metabolic syndrome predicts prostate cancer in a cohort of middle-aged Norwegian men followed for 27 years. Am J Epidemiol 2006, 164:769-774.