Chronic benzodiazepine usage and withdrawal in insomnia patients

Journal of Psychiatric Research

Volumn 38, Issue 3, 2004, Pages 327-334

  Poyares, Dalva ^a,b   Guilleminault, Christian ^b   Ohayon, Maurice M ^c   Tufik, Sergio ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b STANFORD UNIVERSITY   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BZDs benzodiazepines; Chronic benzodiazepine intake; Delta activity; Drug withdrawal; EEG Electroencephalography; Insomnia; NREM non REM; PAA period amplitude analysis; Period amplitude analysis; Sleep; SWS slow wave sleep; TST Total sleep time

Indexed keywords

BENZODIAZEPINE; LORAZEPAM;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DRUG USE; ELECTROENCEPHALOGRAM; FEMALE; HUMAN; INSOMNIA; LONG TERM CARE; MALE; NONREM SLEEP; PRIORITY JOURNAL; RECURRENT DISEASE; SLEEP; SLEEP STAGE; SLEEP TIME; SLOW WAVE SLEEP; STATISTICAL SIGNIFICANCE; TREATMENT WITHDRAWAL;

ADULT; BENZODIAZEPINES; CASE-CONTROL STUDIES; DRUG ADMINISTRATION SCHEDULE; DRUG RESISTANCE; FEMALE; HUMANS; MALE; MIDDLE AGED; SLEEP; SLEEP INITIATION AND MAINTENANCE DISORDERS; SUBSTANCE WITHDRAWAL SYNDROME; TREATMENT OUTCOME;

EID: 1542315612     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2003.10.003     Document Type: Article

References (40)

1. American Psychiatry Association. DSM-IV Diagnostic and statistical manual of mental disorders. 4th ed. 1995;American Psychiatry Press, Washington.
2. Armitage R. The distribution of EEG frequencies in REM and NREM sleep stages in healthy young adults. Sleep. 18:1995;334-341.
3. Armitage R., Hoffmann R., Fitch T., Morel C., Bonato R. A comparison of period amplitude and power spectral analysis of sleep EEG in normal adults and depressed out patients. Psychiatry Res. 56:1995;245-256.
4. Bonnet M.H., Arand D.L. The use of lorazepam TID for chronic insomnia. Int Clin Psychopharmacol. 14:1999;81-89.
5. Borbély A.A., Achermann P. Ultradian dynamics of sleep after a single dose of benzodiazepine hypnotics. Eur J Pharmaco. 195:1991;11-18.
6. Borbély A.A., Mattmann P., Loepfe M., Strauch I., Lehmann D. Effect of benzodiazepine hypnotics on all-night sleep EEG spectra. Hum Neurobiol. 4:1985;189-194.
7. Brown G.M., Stancer H.C., Moldofsky H., Harman J., Murphy J.T., Gupta R.N. Withdrawal from long-term high-dose desipramine therapy. Clinical and Biological changes. Arch Gen Psychiatry. 35:1978;1261-1264.
8. Busto U.E., Sellers E.M., Naranjo C.A., Cappell H., Sanchez-Craig M., Sykora K. Withdrawal reaction after long-term therapeutic use of benzodiazepines. N Engl J Med. 315:1986;854-859.
9. Chiu T.H., Rosenberg H.C. Reduced diazepam binding following chronic benzodiazepine treatment. Life Sci. 23:1978;1153-1158.
10. Drewes A.M., Nielsen K.D., Arendt-Nielsen L., Birket-Smith L., Hansen L.M. The effect of cutaneous and deep pain on the electroencephalogram during sleep - and experimental study. Sleep. 20:1997;632-640.
11. Ehlers C.L., Slaweckic J. Effects of chronic ethanol exposure on sleep in rats. Alcohol. 20:2000;173-174.
12. Feinberg I., March J.D., Fein G., Floyd T.C., Walker J.M., Price L. Period amplitude analysis of 0.5-3 c/sec activity in non-REM sleep of young adults. Electroencephalogr Clin Neurophysiol. 44:1978;202-213.
13. Gaillard J.M., Blois R. Differential effects of flunitrazepam on human sleep in combination with flumazenil. Sleep. 12:1989;120-132.
14. Gaillard J.M., Blois R. Sleep pharmacology of typical and atypical ligands of benzodiazepine receptors. Pharmacology Biochemistry & Behavior. 29:1988;799-801.
15. Genton P., Blin O., Borderies P. Substitution of chronic flunitrazepam by placebo or zolpidem a multicentric, double-blind, parallel group study. J Sleep Res. 3(1):1994;172.
16. Gorenstein C., Bernik M.A., Pompeia S. Differential acute psychomotor and cognitive effects of diazepam on long-term benzodiazepine users. Int Clin Psychopharmacol. 9:1994;145-153.
17. Griffiths R.R., Weerts E.M. Benzodiazepine self-administration in humans and laboratory animals implications for problems of long-term use and abuse. Psychopharmacology. 134:1997;137.
18. Kripke D.F., Klauber M.R., Wingard D.L., Fell R.L., Assmus J.D., Garfinkel L. Mortality hazard associated with prescription of hypnotics. Biol Psychiatry. 43:1998;687-693.
19. Lader M., Morton S. Benzodiazepine problems. Br J Addict. 86:1991;823-828.
20. Lader M., Russell J. Guidelines for the prevention and treatment of benzodiazepine dependence: summary of a report from the Mental Health Foundation. Addiction. 88:1993;1707-1708.
21. Lancel M., Faulhaber J., Schiffeltrolz T., Mathias S., Deisz R.A. "Muscimol" and midazolam do not potentiate each other's effects on sleep EEG in the rat. J Neurophysiol. 77:1997;1624-1629.
22. Lemoine P., Ohayon M.M. Is hypnotics withdrawal facilitated by the transitory use of a substitute drug? Prog Neuro-Psych Biol Psych. 21:1997;111-124.
23. Merica H., Blois R., Gaillard J.M. Spectral characteristics of sleep EEG in chronic insomnia. Eur. J. Neurosci. 10:1998;1826-1834.
24. Miller L.G., Greenblatt D.J., Roy R.B., Summer W.R., Shader R.I. Chronic benzodiazepine administration. 11: discontinuation syndrome is associated with up regulation of gamma-aminobutyric acid A receptor complex binding and function. J. Pharmacol. Exp. Ther. 246:1988;177-182.
25. Mitler M.M., Carskadon M.A., Phillip R.L., Sterling W.R., Zarcone V.P. Jr., Spiegel R., Guilleminault C., Demnet W.C. Hypnotic efficacy of temazepam: a long-term sleep laboratory evaluation. Br J Clin Pharmacol. 8:1979;63S-68S.
26. Murphy S.M., Tyrer P.J. A double-blind comparison of the effects of gradual withdrawal of lorazepam, diazepam and bromazepam in benzodiazepine dependence. Br J Psychiatry. 158:1991;511-516.
27. Ohayon M.M., Caulet M., Priest R.G., Guilleminault C. Psychotropic medication consumption patterns in the UK general population. J Clin Epidemiol. 51:1998;273-283.
28. Ohayon M.M., Caulet M., Arbus L., Billard M., Coquerel A., Guieu J.L.et al. Are prescribed medications effective in the treatment of insomnia complaints? J Psychosom Res. 47:1999;359-368.
29. Pailhous E., Monfort J.C., Goldenberg F., Benoit O. Switching off hypnotics under valproic acid in dependents insomniacs. J Sleep Research. 3(1):1994;379.
30. Rechtschaffen A., Kales A. A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Los Angeles Brain Information/Brain Research Institute. UCLA. 1968.
31. Rickels K., Case W.G., Warren G.C., Schweizer E., Garcia-Espana F., Fridman R. Benzodiazepine dependence: management of discontinuation. Psychopharmacol Bull. 26:1990;63-68.
32. Ries R.K., Roy-Byrne P.P., Ward N.G., Neppe P., Cullison S. Carbamazepine treatment for benzodiazepine withdrawal. Am J Psychiatry. 143:1989;536-537.
33. Salzman C. The APA task force report on benzodiazepine dependence, toxicity and abuse (Editorial). Am J Psychiatry. 148:1991;151-152.
34. Schneider-Helmert D. Why low dose benzodiazepine-dependent insomniacs can't escape their sleeping pills. Acta Psychiatr Scand. 78:1988;706-711.
35. Schweizer E., Rickels K., Case W.G., Greenblatt D.J. Carbamazepine treatment in patients discontinuing long-term benzodiazepine therapy. Arch Gen Psychiatry. 48:1991;448-452.
36. Shapiro C.N. Long-term follow-up of hypnotic dependent subjects after successful withdrawal. J Sleep Res. 3(1):1994;469.
37. Sher P.K., Study R.E., Mazzetta J., Barker J.L., Nelson P.G. Depression of benzodiazepine binding and diazepam potentiation of GABA-mediated inhibition after chronic exposure of spinal cord cultures to diazepam. Brain Res. 268:1983;171-176.
38. Smits M.G., Declerck A.C., Verbeek I. Zolpidem improves sleep quality and architecture after abrupt discontinuation of chronic use of benzodiazepine treatment. J Sleep Res. 5:1996;217.
39. Soldatos C.R., Dikeos D.G., Whitehead A. Tolerance and rebound insomnia with rapidly eliminated hypnotics: a meta-analysis of sleep laboratory studies. Int Clin Psychopharmacol. 14:1999;287-303.
40. Uchida S., Okudaira N., Nishihara F., Iguchi Y., Tan X. Flunitrazepam effects on human sleep EEG spectra II: sigma and beta alterations during NREM sleep. Life Sci. 59:1996;117-120.