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The probe used is an unsaturated bicyclic 1,2-diol having a variable substitution pattern. Advantages are the very rapid increase in molecular complexity and its modular character. (a) Finet, L.; Candela Lena, J. I.; Kaoudi, T.; Birlirakis, N.; Arseniyadis, S. Chem. - Eur. J. 2003, 9, 3813-3820.
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The probe used is an unsaturated bicyclic 1,2-diol having a variable substitution pattern. Advantages are the very rapid increase in molecular complexity and its modular character. (a) Finet, L.; Candela Lena, J. I.; Kaoudi, T.; Birlirakis, N.; Arseniyadis, S. Chem. - Eur. J. 2003, 9, 3813-3820.
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2+ but without the toxic and environmental issues: (a) Moriarty, R. M.; Vaid, R. K. Synthesis 1990, 431-447.
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For a discussion of pericyclic reaction transition states, see
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Best preparation of the common intermediate 1: (a) Jung, M. E.; Piizzi, G. Org. Lett. 2003, 5, 137-140.
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23
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36349018418
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It should be pointed out that all domino reactions are performed on crude diastereomeric mixtures; we only show the stereopure target diols for characterization purposes, by separating various amounts of stereopure compounds using the eluent indicated in the experimental part
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It should be pointed out that all domino reactions are performed on crude diastereomeric mixtures; we only show the stereopure target diols for characterization purposes, by separating various amounts of stereopure compounds using the eluent indicated in the experimental part.
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25
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36348964359
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3.
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3.
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26
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36349033623
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13C NMR of the crude material showed no resonances other than those due to the expected products 16-21.
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13C NMR of the crude material showed no resonances other than those due to the expected products 16-21.
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