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Using these conditions, 3-bromoacetophenone underwent cross-coupling with boronic ester 1a in quantitative yield
-
Using these conditions, 3-bromoacetophenone underwent cross-coupling with boronic ester 1a in quantitative yield.
-
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28
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36348941152
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A variety of conditions were employed including elevated temperatures (up to 200°C for 30 min) and stronger bases (such as NaOH).
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A variety of conditions were employed including elevated temperatures (up to 200°C for 30 min) and stronger bases (such as NaOH).
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29
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36348945876
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This process is also compatible with conventional heating. Carbazole 9a was formed in 99% yield when boronic ester 1a was exposed to 3-bromo-4-fluoroacetophenone at 90°C for 12 h
-
This process is also compatible with conventional heating. Carbazole 9a was formed in 99% yield when boronic ester 1a was exposed to 3-bromo-4-fluoroacetophenone at 90°C for 12 h.
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The methylsulfonyl group of 9a can also be removed, although it required more forcing conditions (KOH, MeOH, 70°C, 12 h).
-
The methylsulfonyl group of 9a can also be removed, although it required more forcing conditions (KOH, MeOH, 70°C, 12 h).
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