Safe selection of genetically manipulated human primary keratinocytes with very high growth potential using CD24

Molecular Therapy

Volumn 15, Issue 12, 2007, Pages 2186-2193

  Bergoglio, Valérie ^a,b   Larcher, Fernando ^c   Chevallier Lagente, Odile ^a,b   Bernheim, Alain ^a,b   Danos, Olivier ^d   Sarasin, Alain ^a,b   Del Rio, Marcela ^c   Magnaldo, Thierry ^a,b  

^a CNRS   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c CIEMAT   (Spain)

^d HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD24 ANTIGEN; GREEN FLUORESCENT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CELL CLONE; CELL DIFFERENTIATION; CELL GROWTH; CELL SURFACE; CONTROLLED STUDY; EPIDERMIS CELL; GENETIC ENGINEERING; GENETIC STABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; KERATINOCYTE; MITOSIS; MOUSE; NONHUMAN; SKIN CANCER; STEM CELL GENE THERAPY;

EID: 36348950218     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/sj.mt.6300292     Document Type: Article

References (50)

1. Gallico, GG 3rd, O'Connor, NE, Compton, CC, Kehinde, O and Green, H (1984). Permanent coverage of large burn wounds with autologous cultured human epithelium. N Engl J Med 311: 448-451.
2. Pellegrini, G, Ranno, R, Stracuzzi, G, Bondanza, S, Guerra, L, Zambruno, G et al. (1999). The control of epidermal stem cells (holoclones) in the treatment of massive full-thickness burns with autologous keratinocytes cultured on fibrin. Transplantation 68: 868-879.
3. Ronfard, V, Rives, JM, Neveux, Y, Carsin, H and Barrandon, Y (2000). Long-term regeneration of human epidermis on third degree burns transplanted with autologous cultured epithelium grown on a fibrin matrix. Transplantation 70: 1588-1598.
4. Gache, Y, Baldeschi, C, Del Rio, M, Gagnoux-Palacios, L, Larcher, F, Lacour, JP et al. (2004). Construction of skin equivalents for gene therapy of recessive dystrophic epidermolysis bullosa. Hum Gene Ther 15: 921-933.
5. Choate, KA and Khavari, PA (1997). Sustainability of keratinocyte gene transfer and cell survival in vivo. Hum Gene Ther 8: 895-901.
6. Levy, L, Broad, S, Zhu, AJ, Carroll, JM, Khazaal, I, Peault, B et al. (1998). Optimised retroviral infection of human epidermal keratinocytes: Long-term expression of transduced integrin gene following grafting on to SCID mice. Gene Ther 5: 913-922.
7. Dellambra, E, Vailly, J, Pellegrini, G, Bondanza, S, Golisano, O, Macchia, C et al. (1998). Corrective transduction of human epidermal stem cells in laminin-5-dependent junctional epidermolysis bullosa. Hum Gene Ther 9: 1359-1370.
8. Larcher, F, Del Rio, M, Serrano, F, Segovia, JC, Ramirez, A, Meana, A et al. (2001). A cutaneous gene therapy approach to human leptin deficiencies: Correction of the murine ob/ob phenotype using leptin-targeted keratinocyte grafts. FASEB J 15: 1529-1538.
9. Vailly, J, Gagnoux-Palacios, L, Dell'Ambra, E, Romero, C, Pinola, M, Zambruno, G et al. (1998). Corrective gene transfer of keratinocytes from patients with junctional epidermolysis bullosa restores assembly of hemidesmosomes in reconstructed epithelia. Gene Ther 5: 1322-1332.
10. Dellambra, E, Prislei, S, Salvati, AL, Madeddu, ML, Golisano, O, Siviero, E et al. (2001). Gene correction of integrin β4-dependent pyloric atresia-junctional epidermolysis assembly keratinocytes establishes a role for β4 tyrosines 1422 and 1440 in hemidesmosome assembly. J Biol Chem 276: 41336-41342.
11. Robbins, PB, Lin, Q. Goodnough, JB, Tian, H, Chen, X and Khavari, PA (2001). In vivo restoration of laminin 5 β3 expression and function in junctional epidermolysis bullosa. Proc Natl Acad Sci USA 98: 5193-5198.
12. Arnaudeau-Begard, C, Brellier, F, Chevallier-Lagente, O, Hoeijmakers, J, Bernerd, F, Sarasin, A et al. (2003). Genetic correction of DNA repair-deficient/cancer-prone xeroderma pigmentosum group C keratinocytes. Hum Gene Ther 14: 983-996.
13. Fakharzadeh, SS, Zhang, Y, Sarkar, R and Kazazian, HH Jr. (2000). Correction of the coagulation defect in hemophilia A mice through factor VIII expression in skin. Blood 95: 2799-2805.
14. Watt, FM, Lo Celso, C and Silva-Vargas, V (2006). Epidermal stem cells: an update. Curr Opin Genet Dev 16: 518-524.
15. Fenjves, ES, Yao, SN, Kurachi, K and Taichman, LB (1996). Loss of expression of a retrovirus-transduced gene in human keratinocytes. J Invest Dermatol 106: 576-578.
16. Chen, WY, Bailey, EC, McCune, SL, Dong, JY and Townes, TM (1997). Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase. Proc Natl Acad Sci USA 94: 5798-5803.
17. Bestor, TH (2000). Gene silencing as a threat to the success of gene therapy. J Clin Invest 105: 409-411.
18. Cavazzana-Calvo, M, Hacein-Bey, S, de Saint Basile, G, Gross, F, Yvon, E, Nusbaum, P et al. (2000). Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science 288: 669-672.
19. Mavilio, F, Pellegrini, G, Ferrari, S, Di Nunzio, F, Di Iorio, E, Recchia, A et al. (2006). Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells. Nat Med 12: 1397-1402.
20. Spirito, E, Meneguzzi, G, Danos, O and Mezzina, M (2001). Cutaneous gene transfer and therapy: The present and the future. J Gene Med 3 21-31.
21. Magnaldo, T (2004). Xeroderma pigmentosum: From genetics to hopes and realities of cutaneous gene therapy. Expert Opin Biol Ther 4 169-179.
22. Stockschlaeder, MA, Storb, R, Osborne, WR and Miller, AD (1991). L-histidinol provides effective selection of retrovirus-vector-transduced keratinocytes without impairing their proliferative potential. Hum Gene Ther 2: 33-39.
23. Ghazizadeh, S, Harrington, R, Garfeld, J and Taichman, LB (1998). Retrovirus-mediated transduction of porcine keratinocytes in organ culture. J Invest Dermatol 111: 492-496.
24. Kay, R, Rosten, PM and Humphries, RK (1991). CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor. J Immunol 147 1412-1416.
25. Kay, R, Takei, F and Humphries, RK (1990). Expression cloning of a cDNA encoding M1/69-J11d heat-stable antigens. J Immunol 145: 1952-1959.
26. Shirasawa, T, Akashi, T, Sakamoto, K, Takahashi, H, Maruyama, N and Hirokawa, K (1993). Gene expression of CD24 core peptide molecule in developing brain and developing non-neural tissues. Dev Dyn 198 1-13.
27. Magnaldo, T and Barrandon, Y (1996). CD24 (heat stable antigen, nectadrin), a novel keratinocyte differentiation marker, is preferentially expressed in areas of the hair follicle containing the colony-forming cells. J Cell Sci 109: 3035-3045.
28. Nielsen, PJ, Lorenz, B, Muller, AM, Wenger, RH, Brombacher, F, Simon, M et al. (1997). Altered erythrocytes and a leaky block in B-cell development in CD24/HSA-deficient mice. Blood 89: 1058-1067.
29. Rochat, A, Kobayashi, K and Barrandon, Y (1994). Location of stem cells of human hair follicles by clonal analysis. Cell 76: 1063-1073.
30. Barrandon, Y and Green, H (1987). Three clonal types of keratinocyte with different capacities for multiplication. Proc Natl Acad Sci USA 84: 2302-2306.
31. Ohyama, M, Terunuma, A, Tock, CL, Radonovich, MF, Pise-Masison, CA, Hopping, SB et al. (2006). Characterization and isolation of stem cell-enriched human hair follicle bulge cells. J Clin Invest 116: 249-260.
32. Terunuma, A, Jackson, KL, Kapoor, V, Telford, WG and Vogel, JC (2003). Side population keratinocytes resembling bone marrow side population stem cells are distinct from label-retaining keratinocyte stem cells. J Invest Dermatol 121: 1095-1103.
33. Claudinot, S, Nicolas, M, Oshima, H, Rochat, A and Barrandon, Y (2005). Long-term renewal of hair follicles from clonogenic multipotent stem cells. Proc Natl Acad Sci USA 102: 14677-14682.
34. Pawliuk, R, Kay, R, Lansdorp, P and Humphries, RK (1994). Selection of retrovirally transduced hematopoietic cells using CD24 as a marker of gene transfer. Blood 84: 2868-2877.
35. Bernerd, F, Asselineau, D, Vioux, C, Chevallier-Lagente, O, Bouadjar, B, Sarasin, A et al. (2001). Clues to epidermal cancer proneness revealed by reconstruction of DNA repair-deficient xeroderma pigmentosum skin in vitro. Proc Natl Acad Sci USA 98: 7817-7822.
36. Giancotti, FG and Ruoslahti, E (1999). Integrin signaling. Science 285: 1028-1032.
37. Fuchs, E and Byrne, C (1994). The epidermis: Rising to the surface. Curr Opin Genet Dev 4: 725-736.
38. Del Rio, M, Larcher, F, Serrano, F, Meana, A, Munoz, M, Garcia, M et al. (2002). A preclinical model for the analysis of genetically modified human skin in vivo. Hum Gene Ther 13: 959-968.
39. Kristiansen, G, Winzer, KJ, Mayordomo, E, Bellach, J, Schluns, K, Denkert, C et al. (2003). CD24 expression is a new prognostic marker in breast cancer. Clin Cancer Res 9: 4906-4913.
40. Kristiansen, G, Schluns, K, Yongwei, Y, Denkert, C, Dietel, M and Petersen, I (2003). CD24 is an independent prognostic marker of survival in nonsmall cell lung cancer patients. Br J Cancer 88: 231-236.
41. Baumann, P, Cremers, N, Kroese, F, Orend, G, Chiquet-Ehrismann, R, Uede, T et al. (2005). CD24 expression causes the acquisition of multiple cellular properties associated with tumor growth and metastasis. Cancer Res 65: 10783-10793.
42. Smith, SC, Oxford, G, Wu, Z, Nitz, MD, Conaway, M, Frierson, HF et al. (2006). The metastasis-associated gene CD24 is regulated by Ral GTPase and is a mediator of cell proliferation and survival in human cancer. Cancer Res 66: 1917-1922.
43. Al-Hajj, M, Wicha, MS, Benito-Hernandez, A, Morrison, SJ and Clarke, MF (2003). Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 100: 3983-3988.
44. - breast cancer cells exhibit enhanced invasive properties: An early step necessary for metastasis. Breast Cancer Res 8: R59.
45. -/low cells in breast cancer may not be associated with clinical outcome but may favor distant metastasis. Clin Cancer Res 11: 1154-1159.
46. Liu, R, Wang, X, Chen, GY, Dalerba, P, Gurney, A, Hoey, T et al. (2007). The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med 356: 217-226.
47. Khavari, PA (2006). Modelling cancer in human skin tissue. Nat Rev Cancer 6: 270-280.
48. Bajaj, B, Behshad, S and Andreadis, ST (2002). Retroviral gene transfer to human epidermal keratinocytes correlates with integrin expression and is significantly enhanced on fibronectin. Hum Gene Ther 13: 1821-1831.
49. Rheinwald, JG and Green, H (1975). Serial cultivation of strains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells. Cell 6: 331-343.
50. Merten, OW (2004). State-of-the-art of the production of retroviral vectors. J Gene Med 6 (suppl. 1): S105-S124.