Role of mutation independent constitutive activation of FLT3 in juvenile myelomonocytic leukemia

Haematologica

Volumn 92, Issue 11, 2007, Pages 1557-1560

  De Vries, Andrica C H ^a   Stam, Ronald W ^a   Schneider, Pauline ^a   Niemeyer, Charlotte M ^b   Van Wering, Elisabeth R ^c   Haas, Oskar A ^d   Kratz, Christian P ^b   Den Boer, Monique L ^a   Pieters, Rob ^a   Van Den Heuvel Eibrink, Marry M ^a,c  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b UNIVERSITY OF FREIBURG   (Germany)

^c DUTCH CHILDHOOD ONCOLOGY GROUP   (Netherlands)

^d CHILDREN'S CANCER RESEARCH INSTITUTE   (Austria)

Author keywords

FLT3; JMML; PKC412

Indexed keywords

CD135 ANTIGEN; FLT3 LIGAND; MESSENGER RNA; MIDOSTAURIN;

ARTICLE; CELL ASSAY; CHEMOSENSITIVITY; CHILD; CHILDHOOD LEUKEMIA; CONTROLLED STUDY; DRUG EFFICACY; HUMAN; HUMAN CELL; INFANT; MUTATIONAL ANALYSIS; MYELOMONOCYTIC LEUKEMIA; PROTEIN EXPRESSION;

ENZYME ACTIVATION; ENZYME INHIBITORS; FMS-LIKE TYROSINE KINASE 3; HUMANS; LEUKEMIA, MYELOMONOCYTIC, JUVENILE; RNA, MESSENGER; STAUROSPORINE;

EID: 36348934010     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: 10.3324/haematol.11201     Document Type: Article

References (19)

1. Flotho C, Valcamonica S, Mach-Pascual S, Schmahl G, Corral L, Ritterbach J, et al. RAS mutations and clonality analysis in children with juvenile myelomonocytic leukemia (JMML). Leukemia 1999;13:32-7.
2. Tartaglia M, Niemeyer CM, Fragale A, Song X, Buechner J, Jung A, et al. Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nat Genet 2003;34:148-50.
3. Side LE, Emanuel PD, Taylor B, Franklin J, Thompson P, Castleberry RP, et al. Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1. Blood 1998;92:267-72.
4. Kiyoi H, Naoe T, Nakano Y, Yokota S, Minami S, Miyawaki S, et al. Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Blood 1999; 93: 3074-80.
5. Stirewalt DL, Kopecky KJ, Meshinchi S, Appelbaum FR, Slovak ML, Willman CL, et al. FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia. Blood 2001;97:3589-95.
6. Nicola NA. Hemopoietic cell growth factors and their receptors. Annu Rev Biochem 1989;58:45-77.
7. Stirewalt DL, Radich JP. The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer 2003;3:650-65.
8. Zheng R, Levis M, Piloto O, Brown P, Baldwin BR, Gorin NC, et al. FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells. Blood 2004;103:267-74.
9. Locatelli F, Niemeyer C, Angelucci E, Bender-Gotze C, Burdach S, Ebell W, et al. Allogeneic bone marrow transplantation for chronic myelomonocytic leukemia in childhood: a report from the European Working Group on Myelodysplastic Syndrome in Childhood. J Clin Oncol 1997; 15: 566-73.
10. Niemeyer CM, Aricò M, Basso G, Biondi A, Cantù Rajnoldi A, Creutzig U, et al. Chronic myelomonocytic leukemia in childhood: a retrospective analysis of 110 cases. European Working Group on Myelodysplastic Syndromes in Childhood (EWOG-MDS). Blood 1997;89:3534-43.
11. Gerhardt TM, Schmahl GE, Flotho C, Rath AV, Niemeyer CM. Expression of the Evi-1 gene in haemopoietic cells of children with juvenile myelomonocytic leukaemia and normal donors. Br J Haematol 1997;99:882-7.
12. Stam RW, den Boer ML, Schneider P, Nollau P, Horstmann M, Beverloo HB, et al. Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia. Blood 2005;106:2484-90.
13. Yamamoto Y, Kiyoi H, Nakano Y, Suzuki R, Kodera Y, Miyawaki S, et al. Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood 2001;97:2434-9.
14. Brasel K, Escobar S, Anderberg R, de Vries P, Gruss HJ, Lyman SD. Expression of the flt3 receptor and its ligand on hematopoietic cells. Leukemia 1995;9:1212-8.
15. Gratias EJ, Liu YL, Meleth S, Castleberry RP, Emanuel PD. Activating FLT3 mutations are rare in children with juvenile myelomonocytic leukemia. Pediatr Blood Cancer 2005;44:142-6.
16. Xu F, Taki T, Yang HW, Hanada R, Hongo T, Ohnishi H, et al. Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children. Br J Haematol 1999;105:155-62.
17. Armstrong SA, Kung AL, Mabon ME, Silverman LB, Stam RW, Den Boer ML, et al. Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification. Cancer Cell 2003;3:173-83.
18. Rosnet O, Schiff C, Pebusque MJ, Marchetto S, Tonnelle C, Toiron Y, et al. Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells. Blood. 1993;82:1110-9.
19. Kong AN, Yu R, Chen C, Mandlekar S, Primiano T. Signal transduction events elicited by natural products: role of MAPK and caspase pathways in homeostatic response and induction of apoptosis. Arch Pharm Res 2000;23:1-16.