LHRH-(1-5): a bioactive peptide regulating reproduction

Trends in Endocrinology and Metabolism

Volumn 18, Issue 10, 2007, Pages 386-392

  Roberts, James L ^a   Mani, Shaila K ^b   Woller, Michael J ^c   Glucksman, Marc J ^d   Wu, T John ^e  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF WISCONSIN WHITEWATER   (United States)

^d ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^e UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN; GONADOTROPIN; NEUROPEPTIDE;

AUTOREGULATION; BIOTRANSFORMATION; FEEDBACK SYSTEM; HORMONE RELEASE; HORMONE SYNTHESIS; HUMAN; HYPOTHALAMUS; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REPRODUCTION; REVIEW;

ANIMALS; BRAIN; FEEDBACK, BIOCHEMICAL; FEMALE; GONADOTROPIN-RELEASING HORMONE; HOMEOSTASIS; HUMANS; MALE; METALLOENDOPEPTIDASES; PEPTIDE FRAGMENTS; PITUITARY GLAND; PYRROLIDONECARBOXYLIC ACID; REPRODUCTION;

EID: 36249030000     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tem.2007.09.005     Document Type: Review

References (72)

1. Tsai P.S. Gonadotropin-releasing hormone in invertebrates: structure, function, and evolution. Gen. Comp. Endocrinol. 148 (2006) 48-53
2. Belsham D.D., and Lovejoy D.A. Gonadotropin-releasing hormone: gene evolution, expression, and regulation. Vitam. Horm. 71 (2005) 59-94
3. Fernald R.D., and White R.B. Gonadotropin-releasing hormone genes: phylogeny, structure and function. Front. Neuroendocrinol. 20 (1999) 224-240
4. Millar R.P. GnRHs and GnRH receptors. Anim. Reprod. Sci. 88 (2005) 5-28
5. Hapgood J.P., et al. Regulation of expression of mammalian gonadotrophin-releasing hormone receptor genes. J. Neuroendocrinol. 17 (2005) 619-638
6. Klausen C., et al. Multiplicity of gonadotropin-releasing hormone signaling: a comparative perspective. Prog. Brain Res. 141 (2002) 111-128
7. Ramakrishnappa N., et al. GnRH in non-hypothalamic reproductive tissues. Anim. Reprod. Sci. 88 (2005) 95-113
8. Vereczki V., et al. Distribution of hypothalamic, hippocampal and other limbic peptidergic neuronal cell bodies giving rise to retinopetal fibers: anterograde and retrograde tracing and neuropeptide immunohistochemical studies. Neuroscience 140 (2006) 1089-1100
9. Adam C.L., et al. Blood-brain leptin transport and appetite and reproductive neuroendocrine responses to intracerebroventricular leptin injection in sheep: influence of photoperiod. Endocrinology 147 (2006) 4589-4598
10. Skinner D.C., et al. Simultaneous measurement of gonadotropin-releasing hormone in the third ventricular cerebrospinal fluid and hypophyseal portal blood of the ewe. Endocrinology 138 (1997) 4699-4704
11. Skinner D.C., and Caraty A. Measurement and possible function of GnRH in cerebrospinal fluid in ewes. Reprod. Suppl. 59 (2002) 25-39
12. Sisk C.L., et al. In vivo gonadotropin-releasing hormone secretion in female rats during peripubertal development and on proestrus. Endocrinology 142 (2002) 2929-2936
13. Dudas B., and Merchenthaler I. Three-dimensional representation of the neurotransmitter systems of the human hypothalamus: inputs of the gonadotrophin hormone-releasing hormone neuronal system. J. Neuroendocrinol. 18 (2006) 79-95
14. Eisthen H.L., et al. Neuromodulatory effects of gonadotropin releasing hormone on olfactory receptor neurons. J. Neurosci. 20 (2000) 3947-3955
15. Lu F., et al. Activation of gonadotropin-releasing hormone receptors produces neuronal excitation in the rat hippocampus. Chin. J. Physiol. 42 (1999) 67-71
16. Piva F., et al. "Ultrashort" control of hypothalamic hormones secretion: a brief history. J. Endocrinol. Invest. 27 6 Suppl (2004) 68-72
17. Wu T.J., et al. Stimulation of luteinizing hormone-releasing hormone (LHRH) gene expression in GT1-7 cells by its metabolite, LHRH-(1-5). Endocrinology 146 (2005) 280-286
18. DePaolo L.V., et al. In vivo and in vitro examination of an autoregulatory mechanism for luteinizing hormone-releasing hormone. Endocrinology 120 (1987) 272-279
19. Woller M.J., et al. Dissecting autocrine effects on pulsatile release of gonadotropin-releasing hormone in cultured rat hypothalamic tissue. Exp. Biol. Med. 229 (2004) 56-64
20. Han Y.G., et al. Negative regulation of gonadotropin-releasing hormone and gonadotropin-releasing hormone receptor gene expression by a gonadotropin-releasing hormone agonist I the rat hypothalamus. J. Neuroendocrinol. 11 (1999) 195-201
21. Krsmanovic L.Z., et al. Expression of gonadotropin-releasing hormone receptors and autocrine regulation of neuropeptide release in immortalized hypothalamic neurons. Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 3908-3912
22. Krsmanovic L.Z., et al. Autocrine regulation of gonadotropin-releasing hormone secretion in cultured hypothalamic neurons. Endocrinology 140 (1999) 1423-1431
23. Baldwin E.L., et al. Regulation of type II luteinizing hormone-releasing hormone (LHRH-II) gene expression by the processed peptide of LHRH-I, LHRH-(1-5) in endometrial cells. Exp. Biol. Med. (Mightwood) 232 (2007) 146-155
24. Yamanaka C., et al. Early prepubertal ontogeny of pulsatile gonadotropin-releasing hormone (GnRH) secretion: I. Inhibitory autofeedback control through prolyl endopeptidase degradation of GnRH. Endocrinology 140 (1999) 4609-4615
25. Autelitano D.J., et al. The cryptome: a subset of the proteome, comprising cryptic peptides with distinct bioactivities. Drug Discov. Today 11 (2007) 306-314
26. Donnelly R., and Manning G. Angiotensin-converting enzyme inhibitors and coronary heart disease prevention. J. Renin Angiotensin Aldosterone Syst. 8 (2007) 13-22
27. Keidar S., et al. ACE2 of the heart: From angiotensin I to angiotensin (1-7). Cardiovasc. Res. 73 (2007) 463-469
28. Shrimpton C.N., et al. Soluble metalloendopeptidases and neuroendocrine signaling. Endocr. Rev. 23 (2002) 647-664
29. Hallberg M., and Nyberg F. Neuropeptide conversion to bioactive fragments-an important pathway in neuromodulation. Curr. Protein Pept. Sci. 4 (2003) 31-44
30. Kim S.I., et al. Novel roles of neuropeptide processing enzymes: EC3.4.24.15 in the neurome. J. Neurosci. Res. 74 (2003) 456-467
31. IUBMB. Enzyme Nomenclature (1992), Academic Press
32. O'Conner J.L., et al. Peptidase activity in the hypothalamus and pituitary of the rat: fluctuations and possible regulatory role of luteinizing hormone releasing hormone-degrading activity during the estrous cycle. Biol. Reprod. 30 (1984) 855-862
33. Orlowski M., et al. Endopeptidase 24.15 from rat testes. Isolation of the enzyme and its specificity toward synthetic and natural peptides, including enkephalin-containing peptides. Biochem. J. 261 (1989) 951-958
34. Wu T.J., et al. Endopeptidase EC 3.4.24.15 presence in the rat median eminence and hypophysial portal blood and its modulation of the luteinizing hormone surge. J. Neuroendocrinol. 9 (1997) 813-822
35. Wu T.J., et al. Facilitation of lordosis in rats by a metabolite of luteinizing hormone releasing hormone. Endocrinology 147 (2006) 2544-2549
36. Bourguignon J.P., et al. Gonadotropin releasing hormone inhibitory autofeedback by subproducts antagonist at N-methyl-D-aspartate receptors: a model of autocrine regulation of peptide secretion. Endocrinology 134 (1994) 1589-1592
37. Walters K., Chin Y.P., and Wu T.J. A processed metabolite of luteinizing hormone-releasing hormone has proliferative effects in endometrial cells. Am. J. Obstet. Gynecol. 196 33 (2007) e1-e5
38. 8. J. Neurochem. 48 (1987) 284-292
39. Brosnihan K.B., et al. Does the angiotensin-converting enzyme (ACE)/ACE2 balance contribute to the fate of angiotensin peptides in programmed hypertension?. Hypertension 46 (2005) 1097-1099
40. Chappell M.C., et al. Novel aspects of the renal renin-angiotensin system: angiotensin-(1-7), ACE2 and blood pressure regulation. Contrib. Nephrol. 143 (2004) 77-89
41. Pierotti A.R., et al. Endopeptidase-24.15 in rat hypothalamic/pituitary/gonadal axis. Mol. Cell. Endocrinol. 76 (1991) 95-103
42. Tullai J.W., et al. The neuropeptide processing enzyme EC 3.4.24.15 is modulated by protein kinase A phosphorylation. J. Biol. Chem. 275 (2002) 36514-36522
43. Crack P.J., et al. The association of metalloendopeptidase EC 3.4.24.15 at the extracellular surface of the AtT20 cell plasma membrane. Brain Res. 835 (1999) 113-124
44. Oliveira V., et al. Calcium modulates endopeptidase 24.15 (EC 3.4.24.15) membrane association, secondary structure and substrate specificity. FEBS J. 272 (2005) 2978-2992
45. Jeske N.A., et al. Metalloendopeptidase EC3.4.24.15 is constitutively released from the exofacial leaflet of lipid rafts in GT1-7 cells. J. Neurochem. 90 (2004) 819-828
46. Witkin J.W. Synchronized neuronal networks: the GnRH system. Microsc. Res. Tech. 44 (1999) 11-18
47. Witkin J.W., et al. Novel associations among gonadotropin-releasing hormone neurons. Endocrinology 136 (1995) 4323-4330
48. Lehman M.N., et al. Ultrastructure and synaptic organization of luteinizing hormone-releasing hormone (LHRH) neurons in the anestrous ewe. J. Comp. Neurol. 273 (1988) 447-458
49. Lebrethon M.C., et al. Effects of in vivo and in vitro administration of ghrelin, leptin and neuropeptide mediators on pulsatile gonadotrophin-releasing hormone secretion from male rat hypothalamus before and after puberty. J. Neuroendocrinol. 19 (2007) 181-188
50. Matagne V., et al. In vitro paradigms for the study of GnRH neuron function and estrogen effects. Ann. N. Y. Acad. Sci. 1007 (2003) 129-142
51. Rasier G., et al. Early maturation of gonadotropin-releasing hormone secretion and sexual precocity after exposure of infant female rats to estradiol or dichlorodiphenyltrichloroethane. Biol. Reprod. 77 (2007) 734-742
52. Blake C.A., and Sawyer C.H. Effects of hypothalamic deafferentation on the pulsatile rhythm in plasma concentrations of luteinizing hormone in ovariectomized rats. Endocrinology 94 (1974) 730-736
53. Yang S.N., et al. Activation of gonadotropin-releasing hormone receptors induces a long-term enhancement of excitatory postsynaptic currents mediated by ionotropic glutamate receptors in the rat hippocampus. Neurosci. Lett. 260 (1999) 33-36
54. Matsuyama S., et al. Simultaneous observation of the GnRH pulse generator activity and plasma concentrations of metabolites and insulin during fasting and subsequent refeeding periods in Shiba goats. J. Reprod. Dev. 50 (2004) 697-704
55. Martinez-Fuentes A.J., et al. Gonadotropin-releasing hormone (GnRH) receptor expression and membrane signaling in early embryonic GnRH Neurons: role in pulsatile neurosecretion. Mol. Endocrinol. 18 (2004) 1808-1817
56. Richter T.A., et al. Synchronization of Ca(2+) oscillations among primate LHRH neurons and nonneuronal cells in vitro. J. Neurophysiol. 88 (2002) 1559-1567
57. Woller M., et al. Release of luteinizing hormone-releasing hormone from enzymatically dispersed rat hypothalamic explants is pulsatile. Biol. Reprod. 59 (1998) 587-590
58. Weiner R.I., et al. Gonadotropin-releasing hormone neuronal cell lines. Front. Neuroendocrinol. 13 (1992) 95-119
59. Krsmanovic L.Z., et al. An agonist-induced switch in G-protein coupling of the gonadotropin-releasing hormone receptor regulates neuropeptide secretion. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 2969-2974
60. Roth C., et al. Autoregulation of the gonadotropin-releasing hormone (GnRH) system during puberty: effects of antagonistic vs agonistic GnRH analogs in a female rat model. J. Endocrinol. 169 (2001) 361-371
61. Landgraf R., and Neumann I.D. Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication. Front. Neuroendocrinol. 25 (2004) 150-176
62. Micevych P.E., and Sinchak K. Neurochemistry of sexual receptivity. In: Blaustein J. (Ed). Handbook of Neurochemistry and Molecular Neurobiology Vol. 21 (2006), Springer
63. Beach F.A. Locks and beagles. Am. Psychol. 24 (1969) 971-989
64. O'Byrne K.T., and Knobil E. Electrophysiological approaches to gonadotrophin releasing hormone pulse generator activity in the rhesus monkey. Hum. Reprod. 8 Suppl. 2 (1993) 37-40
65. Beach F.A. Sexual attractivity, proceptivity, and receptivity in female mammals. Horm. Behav. 7 (1976) 105-138
66. Moss R.L., and Cooper K.J. Temporal relationship of spontaneous and coitus-induced release of luteinizing hormone in the normal cyclic rat. Endocrinology 92 (1973) 1748-1753
67. Moss R.L., and McCann S.M. Induction of mating behavior in rats by luteinizing hormone-releasing factor. Science 181 (1973) 177-179
68. Hofmann H.A. Gonadotropin-releasing hormone signaling in behavioral plasticity. Curr. Opin. Neurobiol. 16 (2006) 343-350
69. Kriegsfeld L.J. Driving reproduction: RFamide peptides behind the wheel. Horm. Behav. 50 (2006) 655-666
70. McCann S.M., et al. The role of nitric oxide (NO) in control of LHRH release that mediates gonadotropin release and sexual behavior. Curr. Pharm. Des. 9 (2003) 381-390
71. Mani S.K. Signaling mechanisms in progesterone-neurotransmitter interactions. Neuroscience 138 (2006) 773-781
72. Deutsch A., and Roberts J. Nonclassic signaling in the brain. In: Byrne J., and Roberts J. (Eds). From Molecules to Networks: An Introduction into Cellular and Molecular Neuroscience (2004), Elsevier 284-300