Patterns of spectrin expression in B-cell lymphomas: Loss of spectrin isoforms is associated with nodule-forming and germinal center-related lymphomas

Modern Pathology

Volumn 20, Issue 12, 2007, Pages 1245-1252

  Gorman, Eric B ^a   Chen, Lugen ^a   Albanese, Joseph ^a   Ratech, Howard ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Hodgkin's lymphoma; Malignant lymphoma; Spectrin

Indexed keywords

FODRIN; SPECTRIN; SPECTRIN BETA SUBUNIT; UNCLASSIFIED DRUG;

ARTICLE; B CELL LYMPHOMA; BURKITT LYMPHOMA; CANCER GRADING; CONTROLLED STUDY; FOLLICULAR LYMPHOMA; GERMINAL CENTER; HODGKIN DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPEROXIDASE STAINING; LYMPH NODE; LYMPHOCYTE; LYMPHOID HYPERPLASIA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 36249022182     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.3800962     Document Type: Article

References (36)

1. Broderick MJ, Winder SJ. Spectrin, alpha-actinin, and dystrophin. Adv Protein Chem 2005;70:203-246.
2. Bennett V, Baines AJ. Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues. Physiol Rev 2001;81:1353-1392.
3. Winkelmann JC, Forget BG. Erythroid and nonerythroid spectrins. Blood 1993;81:3173-3185.
4. Pradhan D, Morrow J. The spectrin-ankyrin skeleton controls CD45 surface display and interleukin-2 production. Immunity 2002;17:303-315.
5. Williams MW, Resneck WG, Kaysser T, et al. Na,K-ATPase in skeletal muscle: two populations of beta-spectrin control localization in the sarcolemma but not partitioning between the sarcolemma and the transverse tubules. J Cell Sci 2001;114:751-762.
6. Bennett PM, Baines AJ, Lecomte MC, et al. Not just a plasma membrane protein: in cardiac muscle cells alpha-II spectrin also shows a close association with myofibrils. J Muscle Res Cell Motil 2004;25:119-126.
7. De Matteis MA, Morrow JS. Spectrin tethers and mesh in the biosynthetic pathway. J Cell Sci 2000;113(Part 13):2331-2343.
8. Goodman SR, Zagon IS. The neural cell spectrin skeleton: a review. Am J Physiol 1986;250:C347-C360.
9. Baines AJ, Pinder JC. The spectrin-associated cytoskeleton in mammalian heart. Front Biosci 2005;10:3020-3033.
10. Evans SS, Wang WC, Gregorio CC, et al. Interferon-alpha alters spectrin organization in normal and leukemic human B lymphocytes. Blood 1993;81:759-766.
11. Repasky EA, Symer DE, Bankert RB. Spectrin immunofluorescence distinguishes a population of naturally capped lymphocytes in situ. J Cell Biol 1984;99:350-355.
12. Dubielecka P, Potoczek S, Jazwiec B, et al. The effect of chemotherapy with fluodarabine/mitoxantrone/dexamethasone on the distribution of spectrin in lymphocytes of non-Hodgkin lymphoma patients. Cell Mol Biol Lett 2001;6:200.
13. Dubielecka PM, Jazwiec B, Potoczek S, et al. Changes in spectrin organisation in leukaemic and lymphoid cells upon chemotherapy. Biochem Pharmacol 2005;69:73-85.
14. Maggio E, van den Berg A, Diepstra A, et al. Chemokines, cytokines and their receptors in Hodgkin's lymphoma cell lines and tissues. Ann Oncol 2002;13(Suppl 1):52-56.
15. Malec M, Soderqvist M, Sirsjo A, et al. Real-time polymerase chain reaction determination of cytokine mRNA expression profiles in Hodgkin's lymphoma. Haematologica 2004;89:679-685.
16. Marshall NA, Christie LE, Munro LR, et al. Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma. Blood 2004;103:1755-1762.
17. Gandhi MK, Lambley E, Duraiswamy J, et al. Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T-cell function in Hodgkin lymphoma patients. Blood 2006;108:2280-2289.
18. Ishida T, Ishii T, Inagaki A, et al. Specific recruitment of CC chemokine receptor 4-positive regulatory T cells in Hodgkin lymphoma fosters immune privilege. Cancer Res 2006;66:5716-5722.
19. Atayar C, Poppema S, Visser L, et al. Cytokine gene expression profile distinguishes CD4+/CD57+ T cells of the nodular lymphocyte predominance type of Hodgkin's lymphoma from their tonsillar counterparts. J Pathol 2006;208:423-430.
20. Browne P, Petrosyan K, Hernandez A, et al. The B-cell transcription factors BSAP, Oct-2, and BOB.1 and the pan-B-cell markers CD20, CD22, and CD79a are useful in the differential diagnosis of classic Hodgkin lymphoma. Am J Clin Pathol 2003;120:767-777.
21. Boudova L, Torlakovic E, Delabie J, et al. Nodular lymphocyte-predominant Hodgkin lymphoma with nodules resembling T-cell/histiocyte-rich B-cell lymphoma: differential diagnosis between nodular lymphocyte-predominant Hodgkin lymphoma and T-cell/histiocyte-rich B-cell lymphoma. Blood 2003;102:3753-3758.
22. Frost M, Newell J, Lones MA, et al. Comparative immunohistochemical analysis of pediatric Burkitt lymphoma and diffuse large B-cell lymphoma. Am J Clin Pathol 2004;121:384-392.
23. Gormley RP, Madan R, Dulau AE, et al. Germinal center and activated B-cell profiles separate Burkitt lymphoma and diffuse large B-cell lymphoma in AIDS and non-AIDS cases. Am J Clin Pathol 2005;124:790-798.
24. Zhang K, Prichard JW, Yoder S, et al. Utility of SKP2 and MIB-1 in grading follicular lymphoma using quantitative imaging analysis. Hum Pathol 2007;38:878-882.
25. Mestre-Escorihuela C, Rubio-Moscardo F, Richter JA, et al. Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas. Blood 2007;109:271-280.
26. Berglund M, Enblad G, Thunberg U, et al. Genomic imbalances during transformation from follicular lymphoma to diffuse large B-cell lymphoma. Mod Pathol 2007;20:63-75.
27. Gamberi B, Gaidano G, Parsa N, et al. Microsatellite instability is rare in B-cell non-Hodgkin's lymphomas. Blood 1997;89:975-979.
28. Nagy M, Balazs M, Adam Z, et al. Genetic instability is associated with histological transformation of follicle center lymphoma. Leukemia 2000;14:2142-2148.
29. Fulop Z, Csernus B, Timar B, et al. Microsatellite instability and hMLH1 promoter hypermethylation in Richter's transformation of chronic lymphocytic leukemia. Leukemia 2003;17:411-415.
30. Pasqualucci L, Neumeister P, Goossens T, et al. Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature 2001;412:341-346.
31. Tse WT, Tang J, Jin O, et al. A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix. J Biol Chem 2001;276:23974-23985.
32. McMahon LW, Walsh CE, Lambert MW. Human alpha spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex. J Biol Chem 1999;274:32904-32908.
33. Tang Y, Katuri V, Dillner A, et al. Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice. Science 2003;299:574-577.
34. Kim SS, Shetty K, Katuri V, et al. TGF-beta signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: role of the beta-spectrin, ELF. Biochem Biophys Res Commun 2006;344:1216-1223.
35. Greenman C, Stephens P, Smith R, et al. Patterns of somatic mutation in human cancer genomes. Nature 2007;446:153-158.
36. Mullighan CG, Goorha S, Radtke I, et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 2007;446:758-764.