Effects of ketogenic diet on epileptiform activity in children with therapy resistant epilepsy

Epilepsy Research

Volumn 77, Issue 2-3, 2007, Pages 134-140

  Hallböök, Tove ^a   Köhler, Sven ^a   Rosén, Ingmar ^a   Lundgren, Johan ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Children; EEG; Epilepsy; Epileptiform activity; Ketogenic diet; Spike detection

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETAZOLAMIDE; CARBAMAZEPINE; CLOBAZAM; CLONAZEPAM; ETHOSUXIMIDE; GABAPENTIN; LAMOTRIGINE; NITRAZEPAM; OXCARBAZEPINE; SULTIAME; VALPROIC ACID;

ADOLESCENT; ARTICLE; ASPHYXIA; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; DISEASE SEVERITY; ENCEPHALITIS; EPILEPSY; EPILEPTIC DISCHARGE; FEMALE; HUMAN; KETOGENIC DIET; MALE; MORBIDITY; PRIORITY JOURNAL; QUALITY OF LIFE; REM SLEEP; SLOW WAVE SLEEP; THERAPY RESISTANCE;

3-HYDROXYBUTYRIC ACID; ADOLESCENT; ATTENTION; CHILD; CHILD, PRESCHOOL; DATA INTERPRETATION, STATISTICAL; DIET THERAPY; DRUG RESISTANCE; ELECTROENCEPHALOGRAPHY; EPILEPSY; FEMALE; HUMANS; KETONE BODIES; MALE; POLYSOMNOGRAPHY; QUALITY OF LIFE; SEIZURES;

EID: 36248983790     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2007.09.008     Document Type: Article

References (48)

1. Anonymous. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. From the Commission on Classification and Terminology of the International League against Epilepsy. Epilepsia 22 (1981) 489-501
2. Anonymous. Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League against Epilepsy. Epilepsia 30 (1989) 389-399
3. Binnie C.D., Kasteleijn-Nolst Trenite D.G., and De Korte R. Photosensitivity as a model for acute antiepileptic drug studies. Electroencephalogr. Clin. Neurophysiol. 63 (1986) 35-41
4. Bough K.J., Schwartzkroin P.A., and Rho J.M. Calorie restriction and ketogenic diet diminish neuronal excitability in rat dentate gyrus in vivo. Epilepsia 44 (2003) 752-760
5. Bough K.J., Wetherington J., Hassel B., Pare J.F., Gawryluk J.W., Greene J.G., Shaw R., Smith Y., Geiger J.D., and Dingledine R.J. Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet. Ann. Neurol. 60 (2006) 223-235
6. Camfield P., Gordon K., Camfield C., Tibbles J., Dooley J., and Smith B. EEG results are rarely the same if repeated within 6 months in childhood epilepsy. Can. J. Neurol. Sci. 22 (1995) 297-300
7. Clarkson P., Adams M.R., Powe A.J., Donald A.E., McCredie R., Robinson J., McCarthy S.N., Keech A., Celermajer D.S., and Deanfield J.E. Oral l-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J. Clin. Invest. 97 (1996) 1989-1994
8. Coman D.J., Sinclair K.G., Burke C.J., Appleton D.B., Pelekanos J.T., O'Neil C.M., Wallace G.B., Bowling F.G., Wang D., De Vivo D.C., and McGill J.J. Seizures, ataxia, developmental delay and the general paediatrician: glucose transporter 1 deficiency syndrome. J. Paediatr. Child Health 42 (2006) 263-267
9. Dahlin M., Elfving A., Ungerstedt U., and Amark P. The ketogenic diet influences the levels of excitatory and inhibitory amino acids in the CSF in children with refractory epilepsy. Epilepsy Res. 64 (2005) 115-125
10. Eriksson A.S., Knutsson E., and Nergardh A. The effect of lamotrigine on epileptiform discharges in young patients with drug-resistant epilepsy. Epilepsia 42 (2001) 230-236
11. Freeman J., Kelly M., and Freeman J. The Epilepsy Diet Treatment: An Introduction to the Ketogenic Diet (1994), Demos, New York
12. Freeman J.M., Vining E.P., Pillas D.J., Pyzik P.L., Casey J.C., and Kelly L.M. The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 children. Pediatrics 102 (1998) 1358-1363
13. Friedman J.R., Thiele E.A., Wang D., Levine K.B., Cloherty E.K., Pfeifer H.H., De Vivo D.C., Carruthers A., and Natowicz M.R. Atypical Glut-1 deficiency with prominent movement disorder responsive to ketogenic diet. Mov. Disord. 21 (2006) 241-245
14. Fujii T., Ho Y.Y., Wang D., De Vivo D.C., Miyajima T., Wong H.Y., Tsang P.T., Shirasaka Y., Kudo T., and Ito M. Three Japanese patients with glucose transporter type 1 deficiency syndrome. Brain Dev. 29 (2007) 92-97
15. Geyelin H. Fasting as a method for treating epilepsy. Med. Rec. 99 (1921) 1037-1039
16. Gordon N., and Newton R.W. Glucose transporter type 1 (Glut-1) deficiency. Brain Dev. 25 (2003) 477-480
17. Gotman J. Relationships between interictal spiking and seizures: human and experimental evidence. Can. J. Neurol. Sci. 18 (1991) 573-576
18. Gotman J., and Yves J. Computer-assisted data collection and analysis. In: Engel J.J., and Pedley T. (Eds). Epilepsy: A Comprehensive Textbook (1997), Lippincott-Raven, Philadelphia 1029-1044
19. Hallbook T., Lundgren J., Blennow G., Stromblad L.-G., and Rosen I. Long term effects on epileptiform activity with vagus nerve stimulation in children. Seizure 14 (2005) 527-533
20. Hallbook T., Lundgren J., and Rosén I. Ketogenic diet improves sleep quality in children with therapy resistant epilepsy. Epilepsia 48 (2007) 59-65
21. Henderson C. Efficacy of the ketogenic diet as a treatment option for epilepsy: meta-analysis. J. Child Neurol. 21 (2006) 193-198
22. Hori A., Tandon P., Holmes G.L., and Stafstrom C.E. Ketogenic diet: effects on expression of kindled seizures and behavior in adult rats. Epilepsia 38 (1997) 750-758
23. Hostetler W.E., Doller H.J., and Homan R.W. Assessment of a computer program to detect epileptiform spikes. Electroencephalogr. Clin. Neurophysiol. 83 (1992) 1-11
24. Keene D.L. A systematic review of the use of the ketogenic diet in childhood epilepsy. Pediatr. Neurol. 35 (2006) 1-5
25. Kokaia M., Holmberg K., Nanobashvili A., Xu Z.Q., Kokaia Z., Lendahl U., Hilke S., Theodorsson E., Kahl U., Bartfai T., Lindvall O., and Hokfelt T. Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 14006-14011
26. Kwiterovich Jr. P.O., Vining E.P., Pyzik P., Skolasky Jr. R., and Freeman J.M. Effect of a high-fat ketogenic diet on plasma levels of lipids, lipoproteins, and apolipoproteins in children. JAMA 290 (2003) 912-920
27. Lefevre F., and Aronson N. Ketogenic diet for the treatment of refractory epilepsy in children: a systematic review of efficacy. Pediatrics 105 (2000) E46
28. Likhodii S.S., and Burnham W.M. Calorie restriction may not elevate the threshold of ptz-induced seizures. Epilepsy Res. 57 (2003) 77-78 (author reply 79-80)
29. Likhodii S.S., Serbanescu I., Cortez M.A., Murphy P., Snead III O.C., and Burnham W.M. Anticonvulsant properties of acetone, a brain ketone elevated by the ketogenic diet. Ann. Neurol. 54 (2003) 219-226
30. Liuba P., Persson J., Luoma J., Yla-Herttuala S., and Pesonen E. Acute infections in children are accompanied by oxidative modification of LDL and decrease of HDL cholesterol, and are followed by thickening of carotid intima-media. Eur. Heart J. 24 (2003) 515-521
31. Martins da Silva A., Aarts J.H., Binnie C.D., Laxminarayan R., Lopes da Silva F.H., Meijer J.W., and Nagelkerke N. The circadian distribution of interictal epileptiform EEG activity. Electroencephalogr. Clin. Neurophysiol. 58 (1984) 1-13
32. Mazarati A.M., Hohmann J.G., Bacon A., Liu H., Sankar R., Steiner R.A., Wynick D., and Wasterlain C.G. Modulation of hippocampal excitability and seizures by galanin. J. Neurosci. 20 (2000) 6276-6281
33. Mendez M., and Radtke R.A. Interactions between sleep and epilepsy. J. Clin. Neurophysiol. 18 (2001) 106-127
34. Mizrahi E.M. Avoiding the pitfalls of EEG interpretation in childhood epilepsy. Epilepsia 37 Suppl. 1 (1996) S41-S51
35. Murphy P., and Burnham W.M. The ketogenic diet causes a reversible decrease in activity level in long-evans rats. Exp. Neurol. 201 (2006) 84-89
36. Nylen K., Likhodii S.S., Hum K.M., and Burnham W.M. A ketogenic diet and diallyl sulfide do not elevate after discharge thresholds in adult kindled rats. Epilepsy Res. 71 (2006) 23-31
37. Pedley T. Interictal epileptiform discharges: discriminating characteristics and clinical correlations. Am. J. EEG Technol. 20 (1980) 101-119
38. Pulsifer M.B., Gordon J.M., Brandt J., Vining E.P., and Freeman J.M. Effects of ketogenic diet on development and behavior: preliminary report of a prospective study. Dev. Med. Child Neurol. 43 (2001) 301-306
39. Sherin J.E., Elmquist J.K., Torrealba F., and Saper C.B. Innervation of histaminergic tuberomammillary neurons by gabaergic and galaninergic neurons in the ventrolateral preoptic nucleus of the rat. J. Neurosci. 18 (1998) 4705-4721
40. Shouse M.N., Farber P.R., and Staba R.J. Physiological basis: how non-REM sleep components can promote and Rem sleep components can suppress seizure discharge propagation. Clin. Neurophysiol. 111 Suppl. 2 (2000) S9-S18
41. Stodieck S., Steinhoff B.J., Kolmsee S., and van Rijckevorsel K. Effect of levetiracetam in patients with epilepsy and interictal epileptiform discharges. Seizure 10 (2001) 583-587
42. Thavendiranathan P., Chow C., Cunnane S., and McIntyre Burnham W. The effect of the 'classic' ketogenic diet on animal seizure models. Brain Res. 959 (2003) 206-213
43. Thio L., Erbayat-Altay E., Rensing N., and Yamada K. Leptins contribute to slower weight gain in juvenile rodents on a ketogenic. Diet Pediatr. Res. 50 10 (2006)
44. Wang J., Akabayashi A., Yu H.J., Dourmashkin J., Alexander J.T., Silva I., Lighter J., and Leibowitz S.F. Hypothalamic galanin: control by signals of fat metabolism. Brain Res. 804 (1998) 7-20
45. Wang D., Pascual J.M., Yang H., Engelstad K., Jhung S., Sun R.P., and De Vivo D.C. Glut-1 deficiency syndrome: clinical, genetic, and therapeutic aspects. Ann. Neurol. 57 (2005) 111-118
46. Wilder R. The effects of ketonemia on the course of epilepsy. Mayo Clin. Proc. (1921) 307-308
47. Wilson S.B., Harner R.N., Duffy F.H., Tharp B.R., Nuwer M.R., and Sperling M.R. Spike detection I: correlation and reliability of human experts. Electroencephalogr. Clin. Neurophysiol. 98 (1996) 186-198
48. Wilson S.B., Turner C.A., Emerson R.G., and Scheuer M.L. Spike detection II: automatic, perception-based detection and clustering. Clin. Neurophysiol. 110 (1999) 404-411