Effect of site-directed PEGylation of trichosanthin on its biological activity, immunogenicity, and pharmacokinetics

Biomolecular Engineering

Volumn 24, Issue 6, 2007, Pages 643-649

  An, Qunxing ^a   Lei, Yingfeng ^b   Jia, Ning ^c   Zhang, Xianqing ^a   Bai, Yinlan ^b   Yi, Jing ^a   Chen, Rui ^a   Xia, Aijun ^a   Yang, Jing ^b   Wei, Sanhua ^d   Cheng, Xiaodong ^a   Fan, Ailing ^a   Mu, Shijie ^a   Xu, Zhikai ^b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c NONE   (China)

^d FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Immunogenicity; Pharmacokinetics; Ribosome inactivating protein; Site directed PEGylation; Trichosanthin

Indexed keywords

BIOACTIVITY; IMMUNOLOGY; PHARMACOKINETICS; POLYETHYLENE GLYCOLS;

IMMUNOGENICITY; RIBOSOME-INACTIVATING PROTEIN; SITE-DIRECTED PEGYLATION; TRICHOSANTHIN;

PROTEINS;

DEOXYRIBONUCLEASE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; RIBOSOME INACTIVATING PROTEIN; TRICHOSANTHIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BAGG ALBINO MOUSE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG HALF LIFE; IC 50; IMMUNOGENICITY; LD 50; MEAN RESIDENCE TIME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; RAT; SITE DIRECTED MUTAGENESIS; SPRAGUE DAWLEY RAT; STATISTICAL ANALYSIS; TUMOR;

ANIMALS; ANTI-HIV AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; MICE; MICE, INBRED BALB C; MUTAGENESIS, SITE-DIRECTED; POLYETHYLENE GLYCOLS; RIBOSOME INACTIVATING PROTEINS; TRICHOSANTHIN;

EID: 36248975290     PISSN: 13890344     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bioeng.2007.10.002     Document Type: Article

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