Cysteine-rich 61 (CCN1) enhances chemotactic migration, transendothelial cell migration, and intravasation by concomitantly up-regulating chemokine receptor 1 and 2

Molecular Cancer Research

Volumn 5, Issue 11, 2007, Pages 1111-1123

  Lin, Been Ren ^a   Chang, Cheng Chi ^a   Chen, Li Ro ^a   Wu, Ming Hsun ^a   Wang, Ming Yang ^a   Kuo, I Hsin ^a   Chu, Chia Yu ^a   Chang, King Jen ^a,b   Lee, Po Huang ^a   Chen, Wei Jao ^a   Kuo, Min Liang ^a,b   Lin, Ming Tsan ^a,b,c  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR2; CYSTEINE RICH PROTEIN 61; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; VERY LATE ACTIVATION ANTIGEN 2; VITRONECTIN RECEPTOR;

ARTICLE; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH ADENOCARCINOMA; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CHEMOTAXIS; ENDOTHELIUM; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMEDIATE-EARLY PROTEINS; INTEGRIN ALPHA2BETA1; INTEGRIN ALPHA3BETA1; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, INTERLEUKIN-8A; RECEPTORS, INTERLEUKIN-8B; SRC-FAMILY KINASES; STOMACH NEOPLASMS; UP-REGULATION;

EID: 36248954890     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-06-0289     Document Type: Article

References (63)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: Globocan 2000. Int J Cancer 2001;94:153-6.
2. Parkin DM, Pisani P, Ferlay J. Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer 1999;80:827-41.
3. Oliveira FJ, Ferrao H, Furtado E, et al. Early gastric cancer: report of 58 cases. Gastric Cancer 1998;1:51-6.
4. Lin MT, Kung SP, Yeh SL, et al. The effect of glutamine-supplemented total parenteral nutrition on nitrogen economy depends on severity of diseases in surgical patients. Clin Nutr 2002;21:213-8.
5. Lin MT, Chou TH, Lai PS, et al. A New Surgical Technique: Mini-invasive surgery for radical subtotal gastrectomy by gasless laparoscopy-assist for early cancer. Hepatogastroenterology 2006;53:843-4.
6. Chambers AF, Groom AC, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2002;2:563-72.
7. Muller A, Homey B, Soto H, et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001;410:50-6.
8. Murphy PM. Chemokines and molecular basis of cancer metastasis. N Engl J Med 2001;354:833-5.
9. Lee J, Horuk R, Rice GC, et al. Characterization of two high affinity human interleukin-8 receptors. J Biol Chem 1992;267:16283-7.
10. Campbell JJ, Butcher EC. Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. Curr Opin Immunol 2000;12:336-41.
11. Zlotnik A, Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity 2000;12:121-7.
12. Sun YX, Wang J, Shelburne CE, et al. Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo. Cell Biochem 2003;89: 462-73.
13. Scotton CJ, Wilson JL, Milliken D, et. al. Epithelial cancer cell migration: a role for chemokine receptors. Cancer Res 2001;61:4961-5.
14. Geminder H, Sagi-Assif O, Goldberg L, et al. A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastoma. J Immunol 2001;167:4747-57.
15. Juarez J, Bendall L. SDF-1 and CXCR4 in normal and malignant hematopoiesis. Histol Histopathol 2004;19:299-309.
16. Balkwill F. Cancer and the chemokine network. Nat Rev Cancer 2004;4:540-50.
17. Murphy C, McGurk M, Pettigrew J, et al. Nonapical and cytoplasmic expression of interleukin-8, CXCR1, and CXCR2 correlates with cell proliferation and microvessel density in prostate cancer. Clin Cancer Res 2005;11:4117-27.
18. Varney ML, Li A, Dave BJ, et al. Expression of CXCR1 and CXCR2 receptors in malignant melanoma with different metastatic potential and their role in interleukin-8(CXCL-8)-mediated modulation of metastatic phenotype. Clin Exp Metastasis 2003;20:723-31.
19. Kuwada Y, Sasaki T, Morinaka K, et al. Potential involvement of IL-8 and its receptors in the invasiveness of pancreatic cancer cells. Int J Oncol 2003;22:765-71.
20. Li A, Varney ML, Singh RK. Expression of interleukin 8 and its receptors in human colon carcinoma cells with different metastatic potentials. Clin Cancer Res 2001;7:3298-304.
21. Lau LF, Nathans D. Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells. EMBO J 1985;4:3145-51.
22. Brigstock DR. The connective tissue growth factor/cycteine-rich 61/nephroblastoma overexpressed (CCN) family. Endocr Rev 1999;20:189-206.
23. Brigstock DR. The CCN family: a new stimulus package. J Endocrinol 2003;178:169-75.
24. Lau LF, Lam SC. The CCN family of angiogenic regulators: the integrin connection. Exp Cell Res 1999;248:44-57.
25. Perbal B. CCN proteins: multifunctional signaling regulators. Lancet 2004;363:62-4.
26. Kireeva ML, Mo FE, Yang GP, et al. Cyr61, a product of a growth factor-inducible immediate-early gene, promotes cell proliferation, migration, and adhesion. Mol Cell Biol 1996;16:1326-34.
27. Xie D, Nakachi K, Wang H, et al. Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features. Cancer Res 2001;61:8917-23.
28. Xie D, Yin D, Tong X, et al. Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and β-Catenin-TCF/Lef signaling pathways. Cancer Res 2004;64:1987-96.
29. Holloway SE, Beck AW, Girard L, et al. Increased expression of Cyr61 (CCN1) identified in peritoneal metastases from human pancreatic cancer. J Am Coll Surg 2005;200:371-7.
30. Lin MT, Zuon CY, Chang CC, et al. Cyr61 induces gastric cancer cell motility/invasion via activation of the integrin/nuclear factor-kappaB/ cyclooxygenase-2 signaling pathway. Clin Cancer Res 2005;11:5809-20.
31. Lin MT, Chang CC, Chen ST, et al. Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of NF-κB-dependent XIAP up-regulation. J Biol Chem 2004;279:24015-23.
32. Eck M, Schmausser B, Scheller K, et al. Pleiotropic effects of CXC chemokines in gastric carcinoma: differences in CXCL8 and CXCL1 expression between diffuse and intestinal types of gastric carcinoma. Clin Exp Immuno 2003;134:508-15.
33. Kwak MK, Hur K, Park DJ, et al. Expression of chemokine receptors in human gastric cancer. Tumour Biol 2005;26:65-70.
34. Burger JA, Burger M, Kipps TJ. Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells. Blood 1999;94:3658-67.
35. Ramjeesingh R, Leung R, Siu CH. Interleukin-8 secreted by endothelial cells induces chemotaxis of melanoma cells through the chemokine receptor CXCR1. FASEB J 2003;17:1292-4.
36. Yamaguchi H, Ishii E, Tashiro K, et al. Role of umblical vein endothelial cells in hematopoiesis. Leuk Lymphoma 1998;31:61-9.
37. Menendez JA, Vellon L, Mehmi I, et al. A novel CYR61-triggered CYR61-αvβ3 integrin loop' regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2MAPK signaling pathway. Oncogene 2005;24:761-79.
38. Kohn AD, Kovacina KS, Roth RA. Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase. EMBO J 1995;14:4288-295.
39. Kireeva ML, Lam SC, Lau LF. Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin αvβ3. J Biol Chem 1998;273:3090-6.
40. Leu SJ, Lam SC, Lau LF. Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins avh3 and a6h1 in human umbilical vein endothelial cells. J Biol Chem 2002;277:46248-55.
41. Grzeszkiewicz TM, Kirschling DJ, Chen N, et al. CYR61 stimulates human skin fibroblast migration through integrin αv-β5 and enhances mitogenesis through integrin αv-β3, independent of its carboxyl-terminal domain. J Biol Chem 2001;276:21943-50.
42. Stupack DG, Cheresh DA. Get a ligand, get a life: integrins, signaling and cell survival. J Cell Sci 2002;115:3729-38.
43. Tsai MS, Bogart DF, Li P, et al. Expression and function of CYR61, an angiogenic factor, in breast cancer cell lines and tumor biopsies. Cancer Res 2002;60:5603-7.
44. Tong X, Xie D, O'Kelly J, et al. Cyr61, a member of CCN family, is a tumor suppressor in non-small cell lung cancer. J Biol Chem 2001;276:47709-14.
45. Sampath D, Winneker RC, Zhang Z. Cyr61, a member of the CCN family, is required for MCF-7 cell proliferation: regulation by 17β-estradiol and over expression in human breast cancer. Endocrinology 2001;142:2540-8.
46. Richards BL, Eisma RJ, Spiro JD, et al. Coexpression of interleukin-8 receptors in head and neck squamous cell carcinoma. Am J Surg 1997;174:507-12.
47. Kitadai Y, Haruma K, Mukaida N, et al. Regulation of disease-progression genes in human gastric carcinoma cells by interleukin 8. Clin Cancer Res 2000;6:2735-40.
48. Miller LJ, Kurtzman SH, Wang Y, et al. Expression of interleukin-8 receptors on tumor cells and vascular endothelial cells in human breast cancer tissues. Anticancer Res 1998;18:77-82.
49. Mashino K, Sadanaga N, Yamaguchi H, et al. Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. Cancer Res 2002;62:2937-41.
50. Gunn MD, Kyuwa S, Tam C, et al. Tobacco, alcohol and the risk of gastric cancer. A population-based case-control study in Sweden. Int J Cancer 1994;57:26-31.
51. Nicolson GL. Metastatic tumor cell attachment and invasion assay utilizing vascular endothelial cell monolayers. J Histochem Cytochem 1982;30:214-20.
52. Cohen MC, Bereta M, Bereta J. Effect of cytokines on tumor cell-endothelial interactions. Indian J Biochem Biophys 1997;34:199-204.
53. Nicolson GL, Irimura T, Nakajima M, et al. Metastatic cell attachment to and invasion of vascular endothelium and its underlying basal lamina using endothelial cell monolayers. Symp Fundam Cancer Res 1983;36:145-67.
54. Chen N, Leu SJ, Todorovic V, et al. Identification of a novel integrin avh3 binding site in CCN1 (CYR61) critical for pro-angiogenic activities in vascular endothelial cells. J Biol Chem 2004;279:44166-76.
55. Schober JM, Chen N, Grzeszkiewicz TM, et al. Identification of integrin α(M)β(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions. Blood 2002;99:4457-65.
56. Wang GK, Zhang W. The signaling network of tumor invasion. Histol Histopathol 2005;20:593-602.
57. Babic AM, Kireeva ML, Kolesnikova TV, et al. CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth. Proc Natl Acad Sci U S A 1998;95:6355-60.
58. Hruska KA, Teitelbaum SL. Renal osteodystrophy. N Engl J Med 1995;333:166-74.
59. Chellaiah M, Fitzgerald C, Filardo EJ, et al. Osteopontin activation of c-src in human melanoma cells requires the cytoplasmic domain of the integrin β v-subunit. Endocrinology 1996;137:2432-40.
60. Obergfell A, Eto K, Mocsai A, et al. Coordinate interactions of Csk, Src, and Syk kinases with [α]IIb[β]3 initiate integrin signaling to the cytoskeleton. J Cell Biol 2002;157:265-75.
61. Arias-Salgado EG, Lizano S, Sarkar S, et al. Src kinase activation by direct interaction with the integrin β cytoplasmic domain. Proc Natl Acad Sci U S A 2003;100:13298-302.
62. Luscinskas FW, Brock AF, Arnaout MA, et al. Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium. J Immunol 1989;142:2257-63.
63. Zijlstra A, Mellor R, Panzarella G, et al. A quantitive analysis of rate-limiting steps in the metastatic cascade using human-specific real-time polymerase chain reaction. Cancer Res 2002;62:7083-7092.