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Volumn 29, Issue 10, 2007, Pages 2134-2153

Evidence-Based Pharmacologic Management of Pulmonary Arterial Hypertension

Author keywords

bosentan; epoprostenol; prostacyclin; pulmonary arterial hypertension; sildenafil; treprostinil

Indexed keywords

ANTICOAGULANT AGENT; BERAPROST; BOSENTAN; CALCIUM CHANNEL BLOCKING AGENT; CONTRACEPTIVE AGENT; CYCLOSPORIN; DIGITALIS; DIURETIC AGENT; ENDOTHELIN RECEPTOR ANTAGONIST; GLIBENCLAMIDE; ILOPROST; PHOSPHODIESTERASE INHIBITOR; PLACEBO; PROSTACYCLIN; SILDENAFIL; UNIPROST; VASODILATOR AGENT;

EID: 36248950177     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2007.10.009     Document Type: Article
Times cited : (70)

References (62)
  • 1
    • 0025837793 scopus 로고
    • Survival in patients with primary pulmonary hypertension. Results from a national prospective registry
    • D'Alonzo G., Barst R., Ayres S., et al. Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann Intern Med 115 (1991) 343-349
    • (1991) Ann Intern Med , vol.115 , pp. 343-349
    • D'Alonzo, G.1    Barst, R.2    Ayres, S.3
  • 2
    • 0023615359 scopus 로고
    • Primary pulmonary hypertension. A national prospective study
    • Rich S., Dantzker D., Ayres S., et al. Primary pulmonary hypertension. A national prospective study. Ann Intern Med 107 (1987) 216-223
    • (1987) Ann Intern Med , vol.107 , pp. 216-223
    • Rich, S.1    Dantzker, D.2    Ayres, S.3
  • 3
    • 2942522878 scopus 로고    scopus 로고
    • Clinical classification of pulmonary hypertension
    • Simonneau G., Galie N., Rubin L., et al. Clinical classification of pulmonary hypertension. J Am Coll Cardiol 43 Suppl 12 (2004) 5S-12S
    • (2004) J Am Coll Cardiol , vol.43 , Issue.SUPPL. 12
    • Simonneau, G.1    Galie, N.2    Rubin, L.3
  • 4
    • 0035797529 scopus 로고    scopus 로고
    • Mutation in the gene for bone morphogenic protein receptor II as a cause of primary pulmonary hypertension in a large kindred
    • [published corrections appear in
    • Newman J., Wheeler L., Lane K., et al. Mutation in the gene for bone morphogenic protein receptor II as a cause of primary pulmonary hypertension in a large kindred. N Engl J Med 345 (2001) 319-324 [published corrections appear in
    • (2001) N Engl J Med , vol.345 , pp. 319-324
    • Newman, J.1    Wheeler, L.2    Lane, K.3
  • 5
    • 0035797529 scopus 로고    scopus 로고
    • Mutation in the gene for bone morphogenic protein receptor II as a cause of primary pulmonary hypertension in a large kindred
    • Newman J., Wheeler L., Lane K., et al. Mutation in the gene for bone morphogenic protein receptor II as a cause of primary pulmonary hypertension in a large kindred. N Engl J Med 345 (2001) 1506
    • (2001) N Engl J Med , vol.345 , pp. 1506
    • Newman, J.1    Wheeler, L.2    Lane, K.3
  • 6
    • 26944485648 scopus 로고    scopus 로고
    • Mutation in the gene for bone morphogenic protein receptor II as a cause of primary pulmonary hypertension in a large kindred
    • ]
    • Newman J., Wheeler L., Lane K., et al. Mutation in the gene for bone morphogenic protein receptor II as a cause of primary pulmonary hypertension in a large kindred. N Engl J Med 346 (2002) 1258 ]
    • (2002) N Engl J Med , vol.346 , pp. 1258
    • Newman, J.1    Wheeler, L.2    Lane, K.3
  • 7
    • 3042511852 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension: Future directions: Report of a National Heart, Lung and Blood Institute/Office of Rare Diseases workshop
    • National Heart, Lung and Blood Institute/Office of Rare Diseases
    • Newman J., Fanburg B., Archer S., et al., National Heart, Lung and Blood Institute/Office of Rare Diseases. Pulmonary arterial hypertension: Future directions: Report of a National Heart, Lung and Blood Institute/Office of Rare Diseases workshop. Circulation 109 (2004) 2947-2952
    • (2004) Circulation , vol.109 , pp. 2947-2952
    • Newman, J.1    Fanburg, B.2    Archer, S.3
  • 8
    • 3142692425 scopus 로고    scopus 로고
    • Screening, early detection and diagnosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines
    • American College of Chest Physicians
    • McGoon M., Gutterman D., Steen V., et al., American College of Chest Physicians. Screening, early detection and diagnosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. Chest 126 Suppl 1 (2004) 14S-34S
    • (2004) Chest , vol.126 , Issue.SUPPL. 1
    • McGoon, M.1    Gutterman, D.2    Steen, V.3
  • 9
    • 3142726157 scopus 로고    scopus 로고
    • Medical therapy for pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines
    • American College of Chest Physicians
    • Badesch D., Abman S., Ahearn G., et al., American College of Chest Physicians. Medical therapy for pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. Chest 126 Suppl 1 (2004) 35S-62S
    • (2004) Chest , vol.126 , Issue.SUPPL. 1
    • Badesch, D.1    Abman, S.2    Ahearn, G.3
  • 11
    • 0020410785 scopus 로고
    • Psychophysical bases of perceived exertion
    • Borg G. Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14 (1982) 377-381
    • (1982) Med Sci Sports Exerc , vol.14 , pp. 377-381
    • Borg, G.1
  • 12
    • 0034107636 scopus 로고    scopus 로고
    • Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension. Comparison with cardiopulmonary exercise testing
    • Miyamoto S., Nagaya N., Satoh T., et al. Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension. Comparison with cardiopulmonary exercise testing. Am J Respir Crit Care Med 161 (2000) 487-492
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 487-492
    • Miyamoto, S.1    Nagaya, N.2    Satoh, T.3
  • 13
    • 23644431874 scopus 로고    scopus 로고
    • Evaluation and management of the patient with pulmonary arterial hypertension
    • Rubin L., and Badesch D. Evaluation and management of the patient with pulmonary arterial hypertension. Ann Intern Med 143 (2005) 282-292
    • (2005) Ann Intern Med , vol.143 , pp. 282-292
    • Rubin, L.1    Badesch, D.2
  • 14
    • 20544448927 scopus 로고    scopus 로고
    • Long-term response to calcium channel blockers in idiopathic pulmonary arterial hypertension
    • Sitbon O., Humbert M., Jais X., et al. Long-term response to calcium channel blockers in idiopathic pulmonary arterial hypertension. Circulation 111 (2005) 3105-3111
    • (2005) Circulation , vol.111 , pp. 3105-3111
    • Sitbon, O.1    Humbert, M.2    Jais, X.3
  • 15
    • 0026632785 scopus 로고
    • The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension
    • Rich S., Kaufmann E., and Levy P. The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension. N Engl J Med 327 (1992) 76-81
    • (1992) N Engl J Med , vol.327 , pp. 76-81
    • Rich, S.1    Kaufmann, E.2    Levy, P.3
  • 16
    • 0026628265 scopus 로고
    • An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension
    • Christman B., McPherson C., Newman J., et al. An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N Engl J Med 327 (1992) 70-75
    • (1992) N Engl J Med , vol.327 , pp. 70-75
    • Christman, B.1    McPherson, C.2    Newman, J.3
  • 17
    • 0033032949 scopus 로고    scopus 로고
    • Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension
    • Tuder R., Cool C., Geraci M., et al. Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension. Am J Respir Crit Care Med 159 (1999) 1925-1932
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 1925-1932
    • Tuder, R.1    Cool, C.2    Geraci, M.3
  • 18
    • 28044452859 scopus 로고    scopus 로고
    • GlaxoSmithKline, Research Triangle Park, NC
    • Flolan (epoprostenol) [package insert] (2002), GlaxoSmithKline, Research Triangle Park, NC
    • (2002) Flolan (epoprostenol) [package insert]
  • 19
    • 0025356811 scopus 로고
    • Treatment of primary pulmonary hypertension with continuous intravenous prostacyclin (epoprostenol). Results of a randomized trial
    • Rubin L., Mendoza J., Hood M., et al. Treatment of primary pulmonary hypertension with continuous intravenous prostacyclin (epoprostenol). Results of a randomized trial. Ann Intern Med 112 (1990) 485-491
    • (1990) Ann Intern Med , vol.112 , pp. 485-491
    • Rubin, L.1    Mendoza, J.2    Hood, M.3
  • 20
    • 0030031888 scopus 로고    scopus 로고
    • A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension
    • Primary Pulmonary Hypertension Study Group
    • Barst R., Rubin L., Long W., et al., Primary Pulmonary Hypertension Study Group. A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. N Engl J Med 334 (1996) 296-302
    • (1996) N Engl J Med , vol.334 , pp. 296-302
    • Barst, R.1    Rubin, L.2    Long, W.3
  • 21
    • 17144452827 scopus 로고    scopus 로고
    • Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trial
    • Badesch D., Tapson V., McGoon M., et al. Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trial. Ann Intern Med 132 (2000) 425-434
    • (2000) Ann Intern Med , vol.132 , pp. 425-434
    • Badesch, D.1    Tapson, V.2    McGoon, M.3
  • 22
    • 0346363598 scopus 로고    scopus 로고
    • Treatment of pulmonary arterial hypertension: A preliminary decision analysis
    • Highland K., Strange C., Mazur J., and Simpson K. Treatment of pulmonary arterial hypertension: A preliminary decision analysis. Chest 124 (2003) 2087-2092
    • (2003) Chest , vol.124 , pp. 2087-2092
    • Highland, K.1    Strange, C.2    Mazur, J.3    Simpson, K.4
  • 23
    • 36249000728 scopus 로고    scopus 로고
    • United Therapeutics Corporation, Silver Spring, Md
    • Remodulin (treprostinil) [package insert] (2006), United Therapeutics Corporation, Silver Spring, Md
    • (2006) Remodulin (treprostinil) [package insert]
  • 24
    • 0037086133 scopus 로고    scopus 로고
    • Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension: A doubleblind, randomized, placebo-controlled trial
    • Treprostinil Study Group
    • Simonneau G., Barst R., Galie N., et al., Treprostinil Study Group. Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension: A doubleblind, randomized, placebo-controlled trial. Am J Respir Crit Care Med 165 (2002) 800-804
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 800-804
    • Simonneau, G.1    Barst, R.2    Galie, N.3
  • 25
    • 12244251412 scopus 로고    scopus 로고
    • Efficacy and safety of treprostinil: An epoprostenol analog for primary pulmonary hypertension
    • Treprostinil Study Group
    • McLaughlin V., Gaine S., Barst R., et al., Treprostinil Study Group. Efficacy and safety of treprostinil: An epoprostenol analog for primary pulmonary hypertension. J Cardiovasc Pharm 41 (2003) 293-299
    • (2003) J Cardiovasc Pharm , vol.41 , pp. 293-299
    • McLaughlin, V.1    Gaine, S.2    Barst, R.3
  • 26
    • 36249001793 scopus 로고    scopus 로고
    • Actelion Pharmaceuticals US, Inc, South San Francisco, Calif
    • Ventavis (iloprost) [package insert] (2006), Actelion Pharmaceuticals US, Inc, South San Francisco, Calif
    • (2006) Ventavis (iloprost) [package insert]
  • 27
    • 0034702248 scopus 로고    scopus 로고
    • Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue
    • Hoeper M., Schwarze M., Ehlerding S., et al. Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue. N Engl J Med 342 (2000) 1866-1870
    • (2000) N Engl J Med , vol.342 , pp. 1866-1870
    • Hoeper, M.1    Schwarze, M.2    Ehlerding, S.3
  • 28
    • 0036682273 scopus 로고    scopus 로고
    • Inhaled iloprost for severe pulmonary hypertension
    • Aerosolized Iloprost Randomized Study Group
    • Olschewski H., Simonneau G., Galie N., et al., Aerosolized Iloprost Randomized Study Group. Inhaled iloprost for severe pulmonary hypertension. N Engl J Med 347 (2002) 322-329
    • (2002) N Engl J Med , vol.347 , pp. 322-329
    • Olschewski, H.1    Simonneau, G.2    Galie, N.3
  • 29
    • 21544449424 scopus 로고    scopus 로고
    • Clinical efficacy and survival with first-line inhaled iloprost therapy in patients with idiopathic pulmonary arterial hypertension
    • Opitz C., Wensel R., Winkler J., et al. Clinical efficacy and survival with first-line inhaled iloprost therapy in patients with idiopathic pulmonary arterial hypertension. Eur Heart J 26 (2005) 1895-1902
    • (2005) Eur Heart J , vol.26 , pp. 1895-1902
    • Opitz, C.1    Wensel, R.2    Winkler, J.3
  • 30
    • 0037322944 scopus 로고    scopus 로고
    • Assessment of the vasodilator response in primary pulmonary hypertension. Comparing prostacyclin and iloprost administered by either infusion or inhalation
    • Opitz C., Wensel R., Bettmann M., et al. Assessment of the vasodilator response in primary pulmonary hypertension. Comparing prostacyclin and iloprost administered by either infusion or inhalation. Eur Heart J 24 (2003) 356-365
    • (2003) Eur Heart J , vol.24 , pp. 356-365
    • Opitz, C.1    Wensel, R.2    Bettmann, M.3
  • 31
    • 0036569119 scopus 로고    scopus 로고
    • Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: A randomized, double-blind, placebo-controlled trial
    • Arterial Pulmonary Hypertension and Beraprost European (ALPHABET) Study Group
    • Galie N., Humbert M., Vachiery J., et al., Arterial Pulmonary Hypertension and Beraprost European (ALPHABET) Study Group. Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: A randomized, double-blind, placebo-controlled trial. J Am Coll Cardiol 39 (2002) 1496-1502
    • (2002) J Am Coll Cardiol , vol.39 , pp. 1496-1502
    • Galie, N.1    Humbert, M.2    Vachiery, J.3
  • 32
    • 0038037766 scopus 로고    scopus 로고
    • Beraprost therapy for pulmonary arterial hypertension
    • Beraprost Study Grop [published correction appears in
    • Barst R., McGoon M., McLaughlin V., et al., Beraprost Study Grop. Beraprost therapy for pulmonary arterial hypertension. J Am Coll Cardiol 41 (2003) 2119-2125 [published correction appears in
    • (2003) J Am Coll Cardiol , vol.41 , pp. 2119-2125
    • Barst, R.1    McGoon, M.2    McLaughlin, V.3
  • 33
    • 10744228331 scopus 로고    scopus 로고
    • Beraprost therapy for pulmonary arterial hypertension
    • Beraprost Study Grop ]
    • Barst R., McGoon M., McLaughlin V., et al., Beraprost Study Grop. Beraprost therapy for pulmonary arterial hypertension. J Am Coll Cardiol 42 (2003) 591 ]
    • (2003) J Am Coll Cardiol , vol.42 , pp. 591
    • Barst, R.1    McGoon, M.2    McLaughlin, V.3
  • 34
    • 0029860546 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of the endothelin-receptor antagonist bosentan in healthy human subjects
    • Weber C., Schmitt R., Birnboeck H., et al. Pharmacokinetics and pharmacodynamics of the endothelin-receptor antagonist bosentan in healthy human subjects. Clin Pharmacol Ther 60 (1996) 124-137
    • (1996) Clin Pharmacol Ther , vol.60 , pp. 124-137
    • Weber, C.1    Schmitt, R.2    Birnboeck, H.3
  • 35
    • 10744230817 scopus 로고    scopus 로고
    • Sitaxsentan therapy for pulmonary arterial hypertension
    • STRIDE-1 Study Group
    • Barst R., Langleben D., Frost A., et al., STRIDE-1 Study Group. Sitaxsentan therapy for pulmonary arterial hypertension. Am J Resp Crit Care Med 169 (2004) 441-447
    • (2004) Am J Resp Crit Care Med , vol.169 , pp. 441-447
    • Barst, R.1    Langleben, D.2    Frost, A.3
  • 36
    • 33646255654 scopus 로고    scopus 로고
    • Treatment of pulmonary arterial hypertension with the selective endothelin- A receptor antagonist sitaxsentan
    • STRIDE-2 Study Group
    • Barst R., Langleben D., Badesch D., et al., STRIDE-2 Study Group. Treatment of pulmonary arterial hypertension with the selective endothelin- A receptor antagonist sitaxsentan. J Am Coll Cardol 47 (2006) 2049-2056
    • (2006) J Am Coll Cardol , vol.47 , pp. 2049-2056
    • Barst, R.1    Langleben, D.2    Badesch, D.3
  • 38
    • 36248997784 scopus 로고    scopus 로고
    • Actelion Pharmaceuticals US, Inc, South San Francisco, Calif
    • Tracleer (bosentan) [package insert] (2007), Actelion Pharmaceuticals US, Inc, South San Francisco, Calif
    • (2007) Tracleer (bosentan) [package insert]
  • 39
    • 0035818316 scopus 로고    scopus 로고
    • Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: A randomized placebo-controlled study
    • Channick R., Simonneau G., Sitbon O., et al. Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: A randomized placebo-controlled study. Lancet 358 (2001) 1119-1123
    • (2001) Lancet , vol.358 , pp. 1119-1123
    • Channick, R.1    Simonneau, G.2    Sitbon, O.3
  • 40
    • 0037149718 scopus 로고    scopus 로고
    • Bosentan therapy for pulmonary arterial hypertension
    • [published correction appears in
    • Rubin L., Badesch D., Barst R., et al. Bosentan therapy for pulmonary arterial hypertension. N Engl J Med 346 (2002) 896-903 [published correction appears in
    • (2002) N Engl J Med , vol.346 , pp. 896-903
    • Rubin, L.1    Badesch, D.2    Barst, R.3
  • 41
    • 0037149718 scopus 로고    scopus 로고
    • Bosentan therapy for pulmonary arterial hypertension
    • ]
    • Rubin L., Badesch D., Barst R., et al. Bosentan therapy for pulmonary arterial hypertension. N Engl J Med 346 (2002) 1258 ]
    • (2002) N Engl J Med , vol.346 , pp. 1258
    • Rubin, L.1    Badesch, D.2    Barst, R.3
  • 43
    • 0035942990 scopus 로고    scopus 로고
    • Sildenafil inhibits hypoxia-induced pulmonary hypertension
    • Zhao L., Mason N., Morrell N., et al. Sildenafil inhibits hypoxia-induced pulmonary hypertension. Circulation 104 (2001) 424-428
    • (2001) Circulation , vol.104 , pp. 424-428
    • Zhao, L.1    Mason, N.2    Morrell, N.3
  • 44
    • 1842530387 scopus 로고    scopus 로고
    • Clinical efficacy of sildenafil in primary pulmonary hypertension: A randomized, placebo-controlled, double-blind, crossover study
    • Sastry B., Narasimhan C., Reddy N., and Raju B. Clinical efficacy of sildenafil in primary pulmonary hypertension: A randomized, placebo-controlled, double-blind, crossover study. J Am Coll Cardiol 43 (2004) 1149-1153
    • (2004) J Am Coll Cardiol , vol.43 , pp. 1149-1153
    • Sastry, B.1    Narasimhan, C.2    Reddy, N.3    Raju, B.4
  • 45
    • 21144437393 scopus 로고    scopus 로고
    • Sildenafil versus endothelin receptor antagonist for pulmonary hypertension (SERAPH) study
    • Wilkins M., Paul G., Strange J., et al. Sildenafil versus endothelin receptor antagonist for pulmonary hypertension (SERAPH) study. Am J Respir Crit Care Med 171 (2005) 1292-1297
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 1292-1297
    • Wilkins, M.1    Paul, G.2    Strange, J.3
  • 46
    • 2942604605 scopus 로고    scopus 로고
    • End points and clinical trial designs in pulmonary arterial hypertension: Clinical and regulatory perspectives
    • Hoeper M., Oudiz R., Peacock A., et al. End points and clinical trial designs in pulmonary arterial hypertension: Clinical and regulatory perspectives. J Am Coll Cardiol 43 Suppl 12S (2004) 48S-55S
    • (2004) J Am Coll Cardiol , vol.43 , Issue.SUPPL. 12S
    • Hoeper, M.1    Oudiz, R.2    Peacock, A.3
  • 47
    • 26444534291 scopus 로고    scopus 로고
    • Sildenafil citrate therapy for pulmonary arterial hypertension
    • Sildenafil Use in Pulmonary Arterial Hypertension (SUPER) Study Group [published correction appears in
    • Galie N., Ghofrani H., Torbicki A., et al., Sildenafil Use in Pulmonary Arterial Hypertension (SUPER) Study Group. Sildenafil citrate therapy for pulmonary arterial hypertension. N Engl J Med 353 (2005) 2148-2157 [published correction appears in
    • (2005) N Engl J Med , vol.353 , pp. 2148-2157
    • Galie, N.1    Ghofrani, H.2    Torbicki, A.3
  • 48
    • 85033574121 scopus 로고    scopus 로고
    • Sildenafil citrate therapy for pulmonary arterial hypertension
    • Sildenafil Use in Pulmonary Arterial Hypertension (SUPER) Study Group ]
    • Galie N., Ghofrani H., Torbicki A., et al., Sildenafil Use in Pulmonary Arterial Hypertension (SUPER) Study Group. Sildenafil citrate therapy for pulmonary arterial hypertension. N Engl J Med 354 (2006) 2400-2401 ]
    • (2006) N Engl J Med , vol.354 , pp. 2400-2401
    • Galie, N.1    Ghofrani, H.2    Torbicki, A.3
  • 49
    • 0242349756 scopus 로고    scopus 로고
    • Long-term treatment with oral sildenafil is safe and improves functional capacity and hemodynamics in patients with pulmonary arterial hypertension
    • Michelakis E., Tymchak W., Noga M., et al. Long-term treatment with oral sildenafil is safe and improves functional capacity and hemodynamics in patients with pulmonary arterial hypertension. Circulation 108 (2003) 2066-2069
    • (2003) Circulation , vol.108 , pp. 2066-2069
    • Michelakis, E.1    Tymchak, W.2    Noga, M.3
  • 50
    • 0041742185 scopus 로고    scopus 로고
    • Bosentan treatment in patients with primary pulmonary hypertension receiving nonparenteral prostanoids
    • Hoeper M., Taha N., Bekjarova A., et al. Bosentan treatment in patients with primary pulmonary hypertension receiving nonparenteral prostanoids. Eur Respir J 22 (2003) 330-334
    • (2003) Eur Respir J , vol.22 , pp. 330-334
    • Hoeper, M.1    Taha, N.2    Bekjarova, A.3
  • 51
    • 4544383466 scopus 로고    scopus 로고
    • Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2
    • Humbert M., Barst R., Robbins I., et al. Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2. Eur Respir J 24 (2004) 353-359
    • (2004) Eur Respir J , vol.24 , pp. 353-359
    • Humbert, M.1    Barst, R.2    Robbins, I.3
  • 52
    • 0037006966 scopus 로고    scopus 로고
    • Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension
    • Ghofrani H., Wiedemann R., Rose F., et al. Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension. Ann Intern Med 136 (2002) 515-522
    • (2002) Ann Intern Med , vol.136 , pp. 515-522
    • Ghofrani, H.1    Wiedemann, R.2    Rose, F.3
  • 53
    • 0037389118 scopus 로고    scopus 로고
    • Long-term treatment with oral sildenafil in addition to continuous IV epoprostenol in patients with pulmonary arterial hypertension
    • Stiebellehner L., Petkov V., Vonbank K., et al. Long-term treatment with oral sildenafil in addition to continuous IV epoprostenol in patients with pulmonary arterial hypertension. Chest 123 (2003) 1293-1295
    • (2003) Chest , vol.123 , pp. 1293-1295
    • Stiebellehner, L.1    Petkov, V.2    Vonbank, K.3
  • 54
    • 10444246635 scopus 로고    scopus 로고
    • Combination therapy with bosentan and sildenafil in idiopathic pulmonary arterial hypertension
    • Hoeper M., Faulenbach C., Golpon H., et al. Combination therapy with bosentan and sildenafil in idiopathic pulmonary arterial hypertension. Eur Respir J 24 (2004) 1007-1010
    • (2004) Eur Respir J , vol.24 , pp. 1007-1010
    • Hoeper, M.1    Faulenbach, C.2    Golpon, H.3
  • 55
    • 33845526777 scopus 로고    scopus 로고
    • Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension
    • McLaughlin V., Oudiz R., Frost A., et al. Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension. Am J Respir Crit Care Med 174 (2006) 1257-1263
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 1257-1263
    • McLaughlin, V.1    Oudiz, R.2    Frost, A.3
  • 56
    • 27744504402 scopus 로고    scopus 로고
    • Goal-oriented treatment and combination therapy for pulmonary arterial hypertension
    • Hoeper M., Markevych I., Spiekerkotter E., et al. Goal-oriented treatment and combination therapy for pulmonary arterial hypertension. Eur Respir J 26 (2005) 858-863
    • (2005) Eur Respir J , vol.26 , pp. 858-863
    • Hoeper, M.1    Markevych, I.2    Spiekerkotter, E.3
  • 57
    • 0036663330 scopus 로고    scopus 로고
    • Chronic oral sildenafil therapy in severe pulmonary artery hypertension
    • Kothari S., and Duggal B. Chronic oral sildenafil therapy in severe pulmonary artery hypertension. Indian Heart J 54 (2002) 404-409
    • (2002) Indian Heart J , vol.54 , pp. 404-409
    • Kothari, S.1    Duggal, B.2
  • 58
    • 0141482069 scopus 로고    scopus 로고
    • Immediate and long-term hemodynamic and clinical effects of sildenafil in patients with pulmonary arterial hypertension receiving vasodilator therapy
    • Bhatia S., Frantz R., Severson C., et al. Immediate and long-term hemodynamic and clinical effects of sildenafil in patients with pulmonary arterial hypertension receiving vasodilator therapy. Mayo Clin Proc 78 (2003) 1207-1213
    • (2003) Mayo Clin Proc , vol.78 , pp. 1207-1213
    • Bhatia, S.1    Frantz, R.2    Severson, C.3
  • 59
    • 0037441640 scopus 로고    scopus 로고
    • Outcome in 91 consecutive patients with pulmonary arterial hypertension receiving epoprostenol
    • Kuhn K., Byrne D., Arbogast P., et al. Outcome in 91 consecutive patients with pulmonary arterial hypertension receiving epoprostenol. Am J Respir Crit Care Med 167 (2003) 580-586
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 580-586
    • Kuhn, K.1    Byrne, D.2    Arbogast, P.3
  • 60
    • 0037151645 scopus 로고    scopus 로고
    • Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: Prognostic factors and survival
    • Sitbon O., Humbert M., Nunes H., et al. Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: Prognostic factors and survival. J Am Coll Cardiol 40 (2002) 780-788
    • (2002) J Am Coll Cardiol , vol.40 , pp. 780-788
    • Sitbon, O.1    Humbert, M.2    Nunes, H.3
  • 61
    • 0037126044 scopus 로고    scopus 로고
    • Survival in primary pulmonary hypertension: The impact of epoprostenol therapy
    • McLaughlin V., Shillington A., and Rich S. Survival in primary pulmonary hypertension: The impact of epoprostenol therapy. Circulation 106 (2002) 1477-1482
    • (2002) Circulation , vol.106 , pp. 1477-1482
    • McLaughlin, V.1    Shillington, A.2    Rich, S.3
  • 62
    • 36248994230 scopus 로고    scopus 로고
    • Frost AE. An update on improving survivability in pulmonary hypertension. http://www.medscape.com/viewarticle/508767. Accessed October 15, 2007.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.