Impaired T-amplitude adaptation to heart rate characterizes IKr inhibition in the congenital and acquired forms of the long QT syndrome

Journal of Cardiovascular Electrophysiology

Volumn 18, Issue 12, 2007, Pages 1299-1305

  Couderc, Jean Philippe ^a   Vaglio, Martino ^a   Xia, Xiajuan ^a   Mcnitt, Scott ^a   Wicker, Pierre ^b   Sarapa, Nenad ^c   Moss, Arthur J ^a   Zareba, Wojciech ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b PFIZER INC   (United States)

^c DAIICHI SANKYO INC   (United States)

Author keywords

Electrocardiography; Heart rate; Long QT syndrome; QT; T wave amplitude

Indexed keywords

POTASSIUM; SOTALOL;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; DOSE RESPONSE; DRUG EFFECT; ELECTROCARDIOGRAM; ELECTROCARDIOGRAPHY; FEMALE; GENE MUTATION; HEART RATE; HOLTER MONITORING; HUMAN; KINETICS; LONG QT SYNDROME; MALE; PENETRANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; QT INTERVAL; QT PROLONGATION; REPOLARIZATION; RR INTERVAL; STATISTICAL SIGNIFICANCE; T WAVE AMPLITUDE;

ADULT; DIAGNOSIS, COMPUTER-ASSISTED; ELECTROCARDIOGRAPHY, AMBULATORY; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HEART RATE; HUMANS; LONG QT SYNDROME; MALE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 36148994006     PISSN: 10453873     EISSN: 15408167     Source Type: Journal    
DOI: 10.1111/j.1540-8167.2007.00960.x     Document Type: Article

References (28)

1. Sanguinetti MC, Curran ME, Spector PS, Keating MT : Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia. Proc Natl Acad Sci USA 1996 93 : 2208 2212.
2. Mitcheson JS, Chen J, Lin M, Culberson C, Sanguinetti MC : A structural basis for drug-induced long QT syndrome. Proc Natl Acad Sci USA 2000 97 : 12329 12333.
3. Chen J, Zou A, Splawski I, Keating MT, Sanguinetti MC : Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation. J Biol Chem 1999 274 : 10113 10118.
4. Furutani M, Trudeau MC, Hagiwara N, Seki A, Gong Q, Zhou Z, Imamura S, Nagashima H, Kasanuki H, Takao A, Momma K, January CT, Robertson GA, Matsuoka R : Novel mechanism associated with an inherited cardiac arrhythmia: Defective protein trafficking by the mutant HERG (G601S) potassium channel. Circulation 1999 99 : 2290 2294.
5. Antzelevitch C, Dumaine R : Electrical heterogeneity in the heart: Physiological, pharmacological, and clinical implications. Handbook of Physiology. The Heart. Bethesda, MD : Am Physiol Soc 2001 : 654 692.
6. Couderc JP, McNitt S, Xia J, Zareba W, Moss AJ : Repolarization morphology in adult LQT2 carriers with borderline prolonged QTc interval. Heart Rhythm 2006 3 : 1460 1466.
7. Chevalier P, Burri H, Adeleine P, Kirkorian G, Lopez M, Leizorovicz A, X-Fouet A, Chapon P, Rubel P, Touboul P : QT dynamicity and sudden death after myocardial infarction: Results of a long-term follow-up study. J Cardiovasc Electrophysiol 2003 14 : 227 233.
8. Krahn AD, Klein GJ, Yee R : Hysteresis of the RT interval with exercise: A new marker for the long-QT syndrome? Circulation 1997 96 : 1551 1556.
9. Fossa AA, Wisialowski T, Crimin K : QT prolongation modifies dynamic restitution and hysteresis of the beat-to-beat QT-TQ interval relationship during normal sinus rhythm under varying states of repolarization. J Pharmacol Exp Ther 2006 316 : 498 506.
10. Sanguinetti MC, Curran ME, Spector PS, Keating MT : Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia. Proc Natl Acad Sci USA 1996 93 : 2208 2212.
11. Antzelevitch C, Shimizu W : Cellular mechanisms underlying the long QT syndrome. Curr Opin Cardiol 2002 17 : 43 51.
12. Sarapa N, Morganroth J, Couderc JP, Francom SF, Darpo B, Fleishaker JC, McEnroe JD, Chen WT, Zareba W, Moss AJ : Electrocardiographic identification of drug-induced QT prolongation: Assessment by different recording and measurement methods. Ann Noninvasive Electrocardiol 2004 9 : 48 57.
13. Couderc JP, Xiaojuan X, Zareba W, Moss AJ : Assessment of the stability of the individual-based correction of QT interval for heart rate. Ann Noninvasive Electrocardiol 2005 10 : 25 34.
14. Lepeschkin E, Surawicz B : The measurement of the Q-T interval of the electrocardiogram. Circulation 1952 6 : 378 388.
15. Badilini F, Maison-Blanche P, Childers R, Coumel P : QT interval analysis on ambulatory electrocardiogram recordings: A selective beat averaging approach. Med Biol Eng Comput 1999 37 : 71 79.
16. McCullagh P, Nelder J : Generalized Linear Models, Second Edition. London : 1989.
17. Neyroud N, Maison-Blanche P, Denjoy I, Chevret S, Donger C, Dausse E, Fayn J, Badilini F, Menhabi N, Schwartz K, Guicheney P, Coumel P : Diagnostic performance of QT interval variables from 24-h electrocardiography in the long QT syndrome. Eur Heart J 1998 19 : 158 165.
18. Merri M, Moss AJ, Benhorin J, Locati EH, Alberti M, Badilini F : Relation between ventricular repolarization duration and cardiac cycle length during 24-hour Holter recordings. Findings in normal patients and patients with long QT syndrome. Circulation 1992 85 : 1816 1821.
19. Nemec J, Buncova M, Bulkova V, Hejlik J, Winter B, Shen WK, Ackerman MJ : Heart rate dependence of the QT interval duration: Differences among congenital long QT syndrome subtypes. J Cardiovasc Electrophysiol 2004 15 : 550 556.
20. Jurkiewicz NK, Sanguinetti MC : Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide. Circ Res 1993 72 : 75 83.
21. Di BD, Langley P, Murray A : Effect of changes in heart rate and in action potential duration on the electrocardiogram T wave shape. Physiol Meas 2002 23 : 355 364.
22. Langley P, Di BD, Murray A : Quantification of T wave shape changes following exercise. Pacing Clin Electrophysiol 2002 25 : 1230 1234.
23. Lehmann MH, Yang H : Sexual dimorphism in the electrocardiographic dynamics of human ventricular repolarization: Characterization in true time domain. Circulation 2001 104 : 32 38.
24. Gima K, Rudy Y : Ionic current basis of electrocardiographic waveforms: A model study. Circ Res 2002 90 : 889 896.
25. Houltz B, Darpo B, Edvardsson N, Blomstrom P, Brachmann J, Crijns HJ, Jensen SM, Svernhage E, Vallin H, Swedberg K : Electrocardiographic and clinical predictors of torsades de pointes induced by almokalant infusion in patients with chronic atrial fibrillation or flutter: A prospective study. Pacing Clin Electrophysiol 1998 21 : 1044 1057.
26. Houltz B, Darpo B, Edvardsson N, Blomstrom P, Brachmann J, Crijns HJ, Jensen SM, Svernhage E, Vallin H, Swedberg K : Electrocardiographic and clinical predictors of torsades de pointes induced by almokalant infusion in patients with chronic atrial fibrillation or flutter: A prospective study. Pacing Clin Electrophysiol 1998 21 : 1044 1057.
27. Houltz B, Darpo B, Swedberg K, Blomstrom P, Brachmann J, Crijns HJ, Jensen SM, Svernhage E, Vallin H, Edvardsson N : Effects of the Ikr-blocker almokalant and predictors of conversion of chronic atrial tachyarrhythmias to sinus rhythm. A prospective study. Cardiovasc Drugs Ther 1999 13 : 329 338.
28. Murray A, McLaughlin NB, Bourke JP, Doig JC, Furniss SS, Campbell RW : Errors in manual measurement of QT intervals. Br Heart J 1994 71 : 386 390.