Effect of major liver resection on hepatic ureagenesis in humans

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 293, Issue 5, 2007, Pages

  Van De Poll, Marcel C G ^a   Wigmore, Stephen J ^b   Redhead, Doris N ^b   Beets Tan, Regina G H ^a   Garden, O James ^b   Greve, Jan Willem M ^a   Soeters, Peter B ^a   Deutz, Nicolaas E P ^a   Fearon, Kenneth C H ^b   Dejong, Cornelis H C ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Computerized tomography volumetry; Liver function; Liver volume; Stable isotopes

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; AMMONIA; ASPARTATE AMINOTRANSFERASE; CARBON 13; INDOCYANINE GREEN; UREA;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; AMINOACIDEMIA; AMMONIA BLOOD LEVEL; ARTERIAL BLOOD; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; LIVER CANCER; LIVER RESECTION; LIVER WEIGHT; MALE; PRIORITY JOURNAL; TUMOR VOLUME; UREA BLOOD LEVEL; UREA CYCLE; VOLUMETRY;

ADULT; AGED; AMINO ACIDS; AMMONIA; BLOOD FLOW VELOCITY; HEPATECTOMY; HUMANS; INDOCYANINE GREEN; LIVER; LIVER CIRCULATION; LIVER NEOPLASMS; METABOLIC CLEARANCE RATE; MIDDLE AGED; NEOPLASM METASTASIS; TOMOGRAPHY, X-RAY COMPUTED; UREA;

EID: 36148986051     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00366.2006     Document Type: Article

References (35)

1. Bianchi G, Marchesini G, Vilstrup H, Fabbri A, De Mitri MS, Zoli M, Pisi E. Hepatic amino-nitrogen clearance to urea-nitrogen in control subjects and in patients with cirrhosis: a simplified method. Hepatology 13: 460-466, 1991.
2. Bruix J, Castells A, Bosch J, Feu F, Fuster J, Garcia-Pagan JC, Visa J, Bru C, Rodes J. Surgical resection of hepatocellular carcinoma in cirrhotic patients: prognostic value of preoperative portal pressure. Gastroenterology 111: 1018-1022, 1996.
3. Dejong CHC, Garden OJ. Neoplasms of the liver. In: Advanced Surgical Practice, edited by Majid AA and Kingsnorth A. London: Greenwich Medical Media, 2003, p. 146-156.
4. Engelen MP, Deutz NE, Mostert R, Wouters EF, Schols AM. Response of whole-body protein and urea turnover to exercise differs between patients with chronic obstructive pulmonary disease with and without emphysema. Am J Clin Nutr 77: 868-874, 2003.
5. Finch MD, Crosbie JL, Currie E, Garden OJ. An 8-year experience of hepatic resection: indications and outcome. Br J Surg 85: 315-319, 1998.
6. Gastaldelli A, Coggan AR, Wolfe RR. Assessment of methods for improving tracer estimation of non-steady-state rate of appearance. J Appl Physiol 87: 1813-1822, 1999.
7. Haber BA, Chin S, Chuang E, Buikhuisen W, Naji A, Taub R. High levels of glucose-6-phosphatase gene and protein expression reflect an adaptive response in proliferating liver and diabetes. J Clin Invest 95: 832-841, 1995.
8. Hamadeh MJ, Hoffer LJ. Tracer methods underestimate short-term variations in urea production in humans. Am J Physiol Endocrinol Metab 274: E547-E553, 1998.
9. Hamberg O, Nielsen K, Vilstrup H. Effects of an increase in protein intake on hepatic efficacy for urea synthesis in healthy subjects and in patients with cirrhosis. J Hepatol 14: 237-243, 1992.
10. Haussinger D. Regulation of hepatic ammonia metabolism: the intercellular glutamine cycle. Adv Enzyme Regul 25: 159-180, 1986.
11. Jahoor F, Wolfe RR. Reassessment of primed constant-infusion tracer method to measure urea kinetics. Am J Physiol Endocrinol Metab 252: E557-E564, 1987.
12. Kawasaki T, Moriyasu F, Kimura T, Someda H, Fukuda Y, Ozawa K. Changes in portal blood flow consequent to partial hepatectomy: Doppler estimation. Radiology 180: 373-377, 1991.
13. Kubota K, Makuuchi M, Kusaka K, Kobayashi T, Miki K, Hasegawa K, Harihara Y, Takayama T. Measurement of liver volume and hepatic functional reserve as a guide to decision-making in resectional surgery for hepatic tumors. Hepatology 26: 1176-1181, 1997.
14. Leu JI, Crissey MA, Leu JP, Ciliberto G, Taub R. Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury. Mol Cell Biol 21: 414-424, 2001.
15. Lodge JP, Menon KV, Fenwick SW, Prasad KR, Toogood GJ. Incontiguity and non-anatomical extension of right hepatic trisectionectomy for liver metastases. Br J Surg 92: 340-347, 2005.
16. Matthews JN, Altman DG, Campbell MJ, Royston P. Analysis of serial measurements in medical research. Br Med J 300: 230-235, 1990.
17. Meijer AJ, Lamers WH, Chamuleau RA. Nitrogen metabolism and ornithine cycle function. Physiol Rev 70: 701-748, 1990.
18. Nagasue N, Yukaya H, Ogawa Y, Kohno H, Nakamura T. Human liver regeneration after major hepatic resection. A study of normal liver and livers with chronic hepatitis and cirrhosis. Ann Surg 206: 30-39, 1987.
19. Olde Damink SW, Deutz NE, Dejong CH, Soeters PB, Jalan R. Interorgan ammonia metabolism in liver failure. Neurochem Int 41: 177-188, 2002.
20. Olde Damink SW, Jalan R, Deutz NE, Redhead DN, Dejong CH, Hynd P, Jalan RA, Hayes PC, Soeters PB. The kidney plays a major role in the hyperammonemia seen after simulated or actual GI bleeding in patients with cirrhosis. Hepatology 37: 1277-1285, 2003.
21. Pol B, Campan P, Hardwigsen J, Botti G, Pons J, Le Treut YP. Morbidity of major hepatic resections: a 100-case prospective study. Eur J Surg 165: 446-453, 1999.
22. Rafoth RJ, Onstad GR. Urea synthesis after oral protein ingestion in man. J Clin Invest 56: 1170-1174, 1975.
23. Ruers T, Bleichrodt RP. Treatment of liver metastases, an update on the possibilities and results. Eur J Cancer 38: 1023-1033, 2002.
24. Schindl MJ, Millar A, Redhead DN, Fearon KCH, Ross JA, Dejong CHC, Garden OJ, Wigmore SJ. The adaptive response of the reticuloendothelial system to major liver resection in man. Ann Surg 243: 507-514, 2006.
25. Schindl MJ, Redhead DN, Fearon KC, Garden OJ, Wigmore SJ. The value of residual liver volume as a predictor of hepatic dysfunction and infection after major liver resection. Gut 54: 289-296, 2005.
26. Schneider PD. Preoperative assessment of liver function. Surg Clin North Am 84: 355-373, 2004.
27. Shirabe K, Shimada M, Gion T, Hasegawa H, Takenaka K, Utsunomiya T, Sugimachi K. Postoperative liver failure after major hepatic resection for hepatocellular carcinoma in the modern era with special reference to remnant liver volume. J Am Coll Surg 188: 304-309, 1999.
28. Shoup M, Gonen M, D'Angelica M, Jarnagin WR, DeMatteo RP, Schwartz LH, Tuorto S, Blumgart LH, Fong Y. Volumetric analysis predicts hepatic dysfunction in patients undergoing major liver resection. J Gastrointest Surg 7: 325-330, 2003.
29. Steele R. Influences of glucose loading and of injected insulin on hepatic glucose output. Ann NY Acad Sci 82: 420-430, 1959.
30. Taub R. Liver regeneration: from myth to mechanism. Nat Rev Mol Cell Biol 5: 836-847, 2004.
31. Tygstrup N, Bak S, Krog B, Pietrangelo A, Shafritz DA. Gene expression of urea cycle enzymes following two-thirds partial hepatectomy in the rat. J Hepatol 22: 349-355, 1995.
32. van Eijk HM, Rooyakkers DR, Deutz NE. Rapid routine determination of amino acids in plasma by high-performance liquid chromatography with a 2-3 microns Spherisorb ODS II column. J Chromatogr 620: 143-148, 1993.
33. van Eijk HM, Rooyakkers DR, Soeters PB, Deutz NE. Determination of amino acid isotope enrichment using liquid chromatography-mass spectrometry. Anal Biochem 271: 8-17, 1999.
34. Vilstrup H. Synthesis of urea after stimulation with amino acids: relation to liver function. Gut 21: 990-995, 1980.
35. Wigmore SJ, Redhead DN, Yan XJ, Casey J, Madhavan K, Dejong CH, Currie EJ, Garden OJ. Virtual hepatic resection using threedimensional reconstruction of helical computed tomography angioportograms. Ann Surg 233: 221-226, 2001.