Infections, B cell receptor activation and autoimmunity: Different check-point impairments lead to autoimmunity, clonal B cell expansion and fibrosis in different immunological settings

Autoimmunity Reviews

Volumn 7, Issue 2, 2007, Pages 109-113

  Ferraccioli, Gianfranco ^a   Tolusso, Barbara ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Activating kinases; B cell receptor; Chronic lymphocytic leukaemia; Hepatitis C; Inhibiting kinases; Lyn; RA; SLE; SSc; Syk

Indexed keywords

B LYMPHOCYTE RECEPTOR;

AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE ACTIVATION; CHRONIC INFLAMMATION; CHRONIC LYMPHATIC LEUKEMIA; CRYOGLOBULINEMIA; DISEASE SEVERITY; EPSTEIN BARR VIRUS; FIBROSIS; HEPATITIS C VIRUS; HUMAN; HUMAN HERPESVIRUS 6; HUMAN HERPESVIRUS 8; IMMUNOREACTIVITY; INFECTION; NONHUMAN; ONCOGENE; REVIEW; RHEUMATOID ARTHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC SCLEROSIS;

ANIMALS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; AUTOIMMUNITY; B-LYMPHOCYTE SUBSETS; B-LYMPHOCYTES; CHRONIC DISEASE; CRYOGLOBULINEMIA; DNA VIRUS INFECTIONS; FIBROSIS; HUMANS; INFLAMMATION; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LYMPHOCYTE ACTIVATION; RECEPTORS, ANTIGEN, B-CELL;

EID: 36148964059     PISSN: 15689972     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autrev.2007.02.013     Document Type: Review

References (34)

1. Klinman D.M., and Steinberg A.D. Systemic autoimmune diseases arises from polyclonal B cell activation. J Exp Med 165 (1987) 1755-1760
2. Hardy R.R., Hayakawa H., Shimizu M., Yamasaki K., and Kishimoto T. Rheumatoid factor secretions from human Leu 1 B cells. Science 236 (1987) 81-83
3. Casali P., Burastero S.E., Nakamura G., Inghirami G., and Notkins A.L. Human lymphocytes making rheumatoid factor and antibody to ssDNA belong to Leu 1 B cell subset. Science 236 (1987) 77-81
4. Berekedjani-Ding I., Inamura S., Grese T., Moll H., Endres S., Sing A., et al. Staphylococcal aureus protein A triggers T cell independent B cell proliferation by sensitizing B cells for TLR2 ligands. J Immunol 178 (2007) 2803-2812
5. Kasajan M.T., Ikematsu H., and Casali P. Identification and analysis of a novel human surface CD5 B lymphocyte subset producing natural antibodies. J Immunol 148 (1992) 2690-2702
6. Gross A.J., Hochberg D., Rand W.M., and Thorley-Lawson D.A. EBV and systemic lupus erythematosus: a new perspective. J Immunol 174 (2005) 6599-6607
7. Leadbetter E.A., Rifkin I.R., Hohlnaum B.C., Beaudette M.J., Shlomchik M.J., and Marshak-Rothstein A. Chromatin IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416 (2002) 603-607
8. Zouali M., and Sarmay G. B lymphocyte signalling pathways in systemic autoimmunity. Arthritis Rheum 50 (2004) 2730-2741
9. Ferri C, Antonelli A, Mascia MT, Sebastiani M, Fallhai P, Ferrari D, et al. B cells and mixed cryoglobulinemia. Autoimmun Rev in press.
10. Dolcetti R. B lymphocytes and Epstein Barr virus: the lesson of post-transplant lymphoproliferative disorders. Autoimmun Rev in press.
11. Barozzi P, Potenza L, Riva G, Vallerini D, Quadrelli C, Bosco R, et al. B cells and herpes-viruses: a model of lymphoproliferation. Autoimmun Rev in press.
12. Zuckerman E. Expansion of CD5+ B cell overexpressing CD81 in HCV infection: towards better understanding the link between HCV infection, B cell activation and lymphoproliferation. J Hepatol 38 (2003) 674-676
13. De Vita S., De Re V., Gasparotto D., Ballare B., Pivetta B., Ferraccioli G., et al. Oligoclonal non neoplastic B cell expansion is the key feature of type II mixed cryoglobulinemia: clinical and molecular findings do not support a bone marrow pathologic diagnosis of indolent B cell lymphoma. Arthritis Rheum 43 (2000) 94-102
14. De Re V., De Vita S., Gasparotto D., Marzotto A., Carbone A., Ferraccioli G., et al. Salivary gland B cell lymphoproliferative disorders in Sjogren's syndrome present a restricted use of antigen receptor gene segments similar to those used by hepatitis C virus associated non Hodgkin's lymphoma. Eur J Immunol 32 (2002) 903-910
15. Harley J.B., Harley I.T.W., Guthridge J.M., and James J.A. The curiously suspicious: a role for Epstein Barr virus in lupus. Lupus 15 (2006) 768-777
16. Kang I., Quan T., Nolasco H., Park S.H., Hong M.S., Crouch J., et al. Defective control of latent Epstein Barr virus infection in systemic lupus erythematosus. J Immunol 172 (2004) 1287-1294
17. Carbonari M., Caprini E., Tedesco T., Mazzetta F., Tocco V., Casato M., et al. Hepatitis C virus drives the unconstrained monoclonal expansion of VH1-69 expressing memory B cells in type II cryoglobulinemia: a model of infection driven lymphomagenesis. J Immunol 174 (2005) 32-39
18. Plater-Zybrec C., Maini R.N., Lam K., Kennedy T.D., and Janossy G. A rheumatoid arthritis B cell subset express a phenotype similar to the chronic lymphatic leukaemia. Arthritis Rheum 28 (1985) 971-976
19. Rifkin I.R., Leadbetter E.A., Beaudette B.C., Kiani C., Monestier M., Shlomchik K.M., et al. Immune complexes presentation in sera of autoimmune mice activate rheumatoid factor B cells. J Immunol 165 (2000) 1625-1633
20. Suzuki N., Sakane T., and Engleman E.G. Anti DNA antibody production by CD5+ and CD5- B cells of patients with systemic lupus erythematosus. J Clin Invest 85 (1990) 238-247
21. Ghia P, Scielzo C, Frenquelli M, Muzio M, Calligaris-Cappio F. From normal to clonal B cells: chronic lymphocytic leukaemia (CLL) at the crossroad between neoplasia and autoimmunity. Autoimmun Rev in press.
22. Efremov DG, Gobessi S, Longo PG. Signaling pathways activated by antigen -receptor engagement in chronic lymphocytic leukaemia B cells. Autoimmun Rev in press.
23. Pritchard N.R., and Smith K.C.G. B cell inhibitory receptors and autoimmunity. Immunology 108 (2003) 263-273
24. Yurasov S., Tiller T., Tsuiji M., Velinzon K., Pascual V., Wardermann H., et al. Persistent expression of autoantibodies in SLE patients in remission. J Exp Med 203 (2006) 2255-2261
25. Picchianti Diamanti A, Rosado MM, Carsetti R, Valesini G. B cells in SLE: different biological drugs for different pathogenic mechanisms. Autoimmun Rev in press.
26. Youinou P, Renaudineau Y. The paradox of CD5 expressing B cells in systemic lupus erythematosus. Autoimmun Rev in press.
27. Samuels J., Yen-Shing Ng, Capillaud C., Paget D., and Meffre E. Impaired early B cell tolerance in patients with rheumatoid arthritis. J Exp Med 201 (2005) 1659-1667
28. Fujimoto M., and Sato S. B lymphocytes and systemic sclerosis. Curr Opin Rheumatol 17 (2005) 746-751
29. Bugatti S, Codullo, Caporali R, Montecucco C. B cells in rheumatoid arthritis. Autoimmun Rev in press.
30. Edwards J.C.W., and Cambridge G. B cell targeting in rheumatoid arthritis and other autoimmune diseases. Nat Rev Immunol 6 (2006) 394-403
31. Gabrielli A, Svegliati S, Moroncini G, Lucchetti M, Tonnini C, Avvedimento EV. Stimulatory autoantibodies to the PDGF receptor: a link to fibrosis in scleroderma and pathway for novel therapeutic targets. Autoimmun Rev in press.
32. Hasegawa M., Hamaguchi Y., Yanaha K., Bouziz J.D., Uchida J., Fujimoto M., et al. B lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight skin mouse model for systemic sclerosis. Am J Pathol 169 (2006) 954-966
33. Sato S., Fujimoto M., Hasegawa M., and Takehara K. Altered blood B lymphocyte homeostasis in systemic sclerosis. Expanded naïve B cells and diminished but activated memory B cells. Arthritis Rheum 50 (2004) 1918-1927
34. Tedder T.F., Poe J.C., Fujimoto M., Haas K.M., and Sato S. The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: systemic sclerosis as a model system. Curr Dir Autoimmun 8 (2005) 55-90