A bioavailability study comparing two oral formulations containing zinc (Zn bis-glycinate vs. Zn gluconate) after a single administration to twelve healthy female volunteers

International Journal for Vitamin and Nutrition Research

Volumn 77, Issue 4, 2007, Pages 243-248

  Gandia, Peggy ^a   Bour, Dorothée ^b   Maurette, Jean Marc ^c   Donazzolo, Yves ^d   Duchène, Patrick ^b   Béjot, Marie ^c   Houin, Georges ^a  

^a UNIVERSITÉ DE TOULOUSE   (France)

^b ADME Bioanalyses   (France)

^c Laboratoire Oenobiol   (France)

^d OPTIMED Clinical Research   (France)

Author keywords

Bis glycinate; Dietary Reference Intake; Gluconate; Oral bioavailability; Zinc

Indexed keywords

GLUCONATE ZINC; UNCLASSIFIED DRUG; ZINC BIS GLYCINATE; ZINC DERIVATIVE;

ADULT; ANALYSIS OF VARIANCE; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG TOLERABILITY; FEMALE; FLAME PHOTOMETRY; HUMAN; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL;

ABSORPTION; ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CROSS-OVER STUDIES; FEMALE; GLUCONATES; GLYCINE; HUMANS;

EID: 36148959298     PISSN: 03009831     EISSN: None     Source Type: Journal    
DOI: 10.1024/0300-9831.77.4.243     Document Type: Article

References (31)

1. Prasad, A.S. (1967) Trace elements in nutrition. Nutritional metabolic role of zinc. Fed. Proc. 26, 172-185.
2. Arrêté du 9 mai 2006 relatif aux nutriments pouvant être employés dans la fabrication des compléments alimentaires. Journal Officiel de la République Française.
3. U.S. Food and Drug Administration (2006) Attachment 33: Pre NLEA Nutritional Labeling Charts. http://www.fda.gov/ora/inspect_ref/igs/nleaattc. html
4. U.S. Government Food and Nutrition Information Center. (2006) List of Dietary References Intakes (DRI) and Recommended Dietary Allowances (RDA). http://www.nal.usda.gov/fnic/etext/000105.html
5. Hambidge, K.M., Casey, C.E. and Krebs, N.F. (1986) Trace Elements in Human and Animal Nutrition. Mertz, W., ed. Orlando, Florida, USA.
6. Favier, A., Arnaud, J. and Faure, H. (1987) Le Zinc en Médecine et en Biologie, Editions Médicales Internationales, Paris, France.
7. Neve, J. and Peretz, A. (1988) [Nutritional importance and physiopathology of zinc]. J. Pharm. Belg. 43, 466-477.
8. Cousins, R.J. (1985) Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin. Physiol. Rev. 65, 238-309.
9. Prasad, A.S. (1985) Clinical manifestations of zinc deficiency. Annu. Rev. Nutr. 5, 341-363.
10. Ronaghy, H.A. (1987) The role of zinc in human nutrition. World Rev. Nutr. Diet. 54, 237-254.
11. Dreno, B., Amblard, P., Agache, P., Sirot, S. and Litoux, P. (1989) Low doses of zinc gluconate for inflammatory acne. Acta Derm. Venereol. 69, 541-543.
12. Keen, C.L. and Gershwin, M.E. (1990) Zinc deficiency and immune function. Annu. Rev. Nutr. 10, 415-431.
13. Escolar, G. and Bulbena, O. (1989) Zinc compounds, a new treatment in peptic ulcer. Drugs Exp. Clin. Res. 15, 83-89.
14. Eby, G.A., Davis, D.R. and Halcomb, W.W. (1984) Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Antimicrob. Agents Chemother. 25, 20-24.
15. Hill, G.M., Brewer, G.J., Juni, J.E., Prasad, A.S. and Dick, R.D. (1986) Treatment of Wilson's disease with zinc. II. Validation of oral 64copper with copper balance. Am. J. Med. Sci. 292, 344-349.
16. Hill, G.M., Brewer, G.J., Prasad, A.S., Hydrick, C.R. and Hartmann, D.E. (1987) Treatment of Wilson's disease with zinc. I. Oral zinc therapy regimens. Hepatology 7, 522-528.
17. Barrie, S.A., Wright, J.V., Pizzorno, J.E., Kutter, E. and Barron, P.C. (1987) Comparative absorption of zinc picolinate, zinc citrate and zinc gluconate in humans. Agents Actions 21, 223-228.
18. Neve, J., Hanocq, M., Peretz, A., Abi Khalil, F. and Pelen, F (1993) [Some factors influencing the bioavailability of zinc in oral pharmaceutical dosage forms]. J. Pharm. Belg. 48, 5-11.
19. Neve, J., Hanocq, M., Peretz, A., Khalil, F.A. and Pelen, F. (1992) Absorption and metabolism of oral zinc gluconate in humans in fasting state, during, and after a meal. Biol. Trace Elem. Res. 32, 201-212.
20. Ashmead, S.D., Graff, D.J. and Ashmead, H.H. (1985) Intestinal absorption of metal ions and chelates, Charles C. Thomas Publisher, Springfield, Illinois, USA.
21. Szarfarc, S.C., de Cassana, L.M., Fujimori, E., Guerra-Shinohara, E.M. and de Oliveira, I.M. (2001) Relative effectiveness of iron bis-glycinate chelate (Ferrochel) and ferrous sulfate in the control of iron deficiency in pregnant women. Arch. Latinoam. Nutr. 51, 42-47.
22. Olivares, M. and Pizarro, F. (2001) Bioavailability of iron bis-glycinate chelate in water. Arch. Latinoam. Nutr. 51, 22-25.
23. Kapsokefalou, M., Alexandropoulou, I., Komaitis, M. and Politis, I. (2005) In vitro evaluation of iron solubility and dialyzability of various iron fortificants and of iron-fortified milk products targeted for infants and toddlers. Int. J. Food Sci. Nutr. 56, 293-302.
24. Shah, V.P., Midha, K.K., Findlay, J.W., Hill, H.M., Hulse, J.D., McGilveray, I.J. (2000) Bioanalytical method validation - a revisit with a decade of progress. Pharm. Res. 17, 1551-1557.
25. Lellouch, J. and Lazar, P. (1996) Méthodes statistiques en expérimentation biologique. Flammarion, Paris, France.
26. Tran, C.D., Miller, L.V., Krebs, N.F., Lei, S. and Hambidge, K.M. (2004) Zinc absorption as a function of the dose of zinc sulfate in aqueous solution. Am. J. Clin. Nutr. 80, 1570-1573.
27. Ashmead, S.D. (2001) The chemistry of ferrous bis-glycinate chelate. Arch. Latinoam. Nutr. 51, 7-12.
28. Garcia-Casal, M.N. and Layrisse, M. (2001) The effect of change in pH on the solubility of iron bis-glycinate chelate and other iron compounds. Arch. Latinoam. Nutr. 51, 35-36.
29. Hertrampf, E. and Olivares, M. (2004) Iron amino acid chelates. Int. J. Vitam. Nutr. Res. 74, 435-443.
30. Lopez de Romana, D., Lonnerdal, B. and Brown, K.H. (2003) Absorption of zinc from wheat products fortified with iron and either zinc sulfate or zinc oxide. Am. J. Clin. Nutr. 78, 279-283.
31. Fredlund, K., Isaksson, M., Rossander-Hulthen, L., Almgren, A. and Sandberg, A.S. (2006) Absorption of zinc and retention of calcium: dose-dependent inhibition by phytate. J. Trace Elem. Med. Biol. 20, 49-57. Epub 2006 Mar 2.