Solid-phase library synthesis of polyynes similar to natural products

Angewandte Chemie - International Edition

Volumn 46, Issue 44, 2007, Pages 8422-8425

  Lee, Seonwoo ^a   Lee, Taeho ^a   Yun, Mi Lee ^a   Kim, Deukjoon ^a   Kim, Sanghee ^a  

^a Seoul National University   (South Korea)

Author keywords

Combinatorial chemistry; Cross coupling; Natural products; Polyynes; Solid phase synthesis

Indexed keywords

ACETYLENE; DRUG PRODUCTS; SOLID STATE REACTIONS; SYNTHESIS (CHEMICAL);

COMBINATORIAL CHEMISTRY; CROSS COUPLING; NATURAL PRODUCTS; POLYYNES; SOLID PHASE SYNTHESIS;

ORGANIC POLYMERS;

ALKYNE; ANTINEOPLASTIC AGENT; FLUORIDE SODIUM; METAL; POLYACETYLENE DERIVATIVE;

ARTICLE; BIOTECHNOLOGY; CATALYSIS; CHEMICAL MODEL; CHEMISTRY; CHROMATOGRAPHY; COLON TUMOR; DRUG DESIGN; HUMAN; IC 50; METHODOLOGY; PROTEIN ENGINEERING; SYNTHESIS; TUMOR CELL LINE;

ALKYNES; ANTINEOPLASTIC AGENTS; BIOTECHNOLOGY; CATALYSIS; CELL LINE, TUMOR; CHEMISTRY; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY; COLONIC NEOPLASMS; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; METALS; MODELS, CHEMICAL; POLYACETYLENES; PROTEIN ENGINEERING; SODIUM FLUORIDE;

EID: 36148956166     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200703208     Document Type: Article

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34. The exact mechanism of the cytotoxicity of the active members is under investigation. For this study and in vivo testing, ca. 200 mg of the most active members, A5/B3/C1 and A2/B3/C1, were individually prepared without difficulty by the solid-phase method described.