Exploring the structural basis of neurotoxicity in C17-polyacetylenes isolated from water hemlock

Journal of Medicinal Chemistry

Volumn 43, Issue 23, 2000, Pages 4508-4515

  Uwai, K ^a   Ohashi, K ^a   Takaya, Y ^a   Ohta, T ^b   Tadano, T ^c   Kisara, K ^c   Shibusawa, K ^d   Sakakibara, R ^d   Oshima, Y ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^d DAIICHI PURE CHEMICALS CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 CHLORODECA 1,3 DIEN 5 OL; 1 DEHYDROXYVIROL A; 1 IODOPENTYN 5 OL; 4 AMINOBUTYRIC ACID RECEPTOR; CICUTOXIN; DODECA 3,5 DIEN 1 YN 7 OL; POLYACETYLENE; TETRODOTOXIN; UNCLASSIFIED DRUG; VIROL A; VIROL B;

ACETYLATION; ARTICLE; CICUTA VIROSA; CONVULSION; DIAPHRAGM PARALYSIS; DRUG ISOLATION; GEOMETRY; METHYLATION; NEUROTOXICITY; OXIDATION; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ACETYLENE; ACUTE TOXICITY TESTS; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; CEREBRAL CORTEX; CHLORIDE CHANNELS; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; HEMLOCK; ION CHANNEL GATING; LETHAL DOSE 50; MALE; MICE; PLANTS, TOXIC; RADIOLIGAND ASSAY; RATS; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034676323     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000185k     Document Type: Article

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