Anxiogenic effects of activation of NK-1 receptors of the dorsal periaqueductal gray as assessed by the elevated plus-maze, ultrasound vocalizations and tail-flick tests

Neuropeptides

Volumn 41, Issue 6, 2007, Pages 365-374

  Bassi, Gabriel S ^a,b   Nobre, Manoel J ^a,b   de Araújo, João E ^a,b   Brandão, Marcus L ^a,b  

^a Instituto de Neurociencias and Comportamento INeC   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Dorsal PAG; Elevated plus maze; NK 1 receptors; Ultrasound vocalizations

Indexed keywords

NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR AGONIST; SUBSTANCE P [9 SARCOSINE 11 METHIONINE]; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ECHOGRAPHY; MALE; MAZE TEST; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; RAT; TAIL FLICK TEST;

ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; FEAR; MALE; MAZE LEARNING; PAIN MEASUREMENT; PERIAQUEDUCTAL GRAY; RATS; RATS, WISTAR; RECEPTORS, NEUROKININ-1; ULTRASONICS; VOCALIZATION, ANIMAL;

ANIMALIA; RATTUS;

EID: 36049047000     PISSN: 01434179     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.npep.2007.09.004     Document Type: Article

References (61)

1. Aguiar M.S., and Brandão M.L. Conditioned place aversion induced by microinjections of substance P in the dorsal periaqueductal gray. Behavioural Pharmacology 5 (1994) 369-373
2. Aguiar M.S., and Brandão M.L. Effects of microinjections of the neuropeptide Substance P in the dorsal periaqueductal gray of rats submitted to the plus maze test. Physiology & Behavior 60 (1996) 1183-1186
3. Albrechet-Souza L., Oliveira A.R., De Luca M.C.Z., Tomazini F., Santos N.R., and Brandão M.L. A comparative study with two types of elevated plus-maze (transparent vs. opaque walls) on the anxiolytic effects of midazolam, one-trial tolerance and fear-induced analgesia. Progress in Neuropsychopharmacology Biological Psychiatry 29 (2005) 571-579
4. Anseloni V.C.Z., and Brandão M.L. Ethopharmacological analysis of behaviour of rats using variations of the elevated plus-maze. Behavioural Pharmacology 8 (1997) 533-540
5. Bandler R., and Carrive P. Integrated defence reaction elicited by excitatory amino acid microinjection in the midbrain periaqueductal grey region of the unrestrained cat. Brain Research 439 (1988) 95-106
6. Barbaresi P. Immunocytochemical localization of substance P receptor in rat periaqueductal gray matter: a light and electron microscopic study. Journal of Comparative Neurology 398 (1998) 473-490
7. Bassi G.S., Nobre M.J., Carvalho M.C., and Brandão M.L. Substance P injected into the dorsal periaqueductal gray causes anxiogenic effects similar to the long-term isolation as assessed by ultrasound vocalizations measurements. Behavioural Brain Research 182 (2007) 301-307
8. Blanchard D.C., and Blanchard R.J. Crouching as an index of fear. Journal of Comparative Physiological Psychology 67 (1969) 370-375
9. Blanchard D.C., and Blanchard R.J. Innate and conditioned reactions to threat in rats with amygdaloid lesions. Journal of Comparative and Physiological Psychology 81 (1972) 281-290
10. Blanchard R.J., Blanchard D.C., Agullana R., and Weiss S.M. Twenty-two kHz alarm cries to presentation of a predator, by laboratory rats living in visible burrow systems. Physiology & Behavior 50 (1991) 967-972
11. Bolles R.C., and Fanselow M.S. A perceptual-defensive-recuperative model of fear and pain. Behavioral Brain Sciences 2 (1980) 291-301
12. Brandão M.L., Anseloni V.Z., Pandóssio J.E., De Araújo J.E., and Castilho V.M. Neurochemical mechanisms of the defensive behavior in the dorsal midbrain. Neuroscience Biobehavioral Reviews 23 (1999) 863-875
13. Brandão M.L., Troncoso A.C., De Souza Silva M.A., and Huston J.P. The relevance of neuronal substrates of defense in the midbrain tectum to anxiety and stress: empirical and conceptual considerations. European Journal of Pharmacology 463 (2003) 225-233
14. Brandão M.L., Borelli K.G., Nobre M.J., Santos J.M., Albrechet-Souza L., Oliveira A.R., and Martinez R.C. Gabaergic regulation of the neural organization of fear in the midbrain tectum. Neuroscience Biobehavioral Reviews 29 (2005) 1299-1311
15. Brandão M.L., Coimbra N.C., and Leão-Borges P.C. Effects of morphine and midazolam on reactivity to peripheral noxious and central aversive stimuli. Neuroscience Biobehavioral Reviews 14 (1990) 495-499
16. Brudzynski S.M., and Chiu E.M. Behavioural responses of laboratory rats to playback of 22 kHz ultrasonic calls. Physiology & Behavior 57 (1995) 1039-1044
17. Brudzynski S.M., and Holland G. Acoustic characteristics of air puff-induced 22 kHz alarm calls in direct recordings. Neuroscience and Biobehavioral Reviews 29 (2005) 1169-1180
18. Castilho V.M., Macedo C.E., and Brandão M.L. Role of benzodiazepine and serotonergic mechanisms in conditioned freezing and antinociception using electrical stimulation of the dorsal periaqueductal gray as unconditioned stimulus in rats. Psychopharmacology 165 (2002) 77-85
19. Coimbra N.C., De Oliveira R., Freitas R.L., Ribeiro S.J., Borelli K.G., and Brandão M.L. Neuroanatomical approaches of the tectum-reticular pathways and immunohistochemical evidence for serotonin-positive perikarya on neuronal substrates of the superior colliculus and periaqueductal gray matter involved in the elaboration of the defensive behavior and fear-induced analgesia. Experimental Neurology 197 (2006) 93-112
20. Commissaris R.L., Palmer A., Neophytou S., Graham M., Beckett S., and Marsden C.A. Acoustically elicited behaviours in Lister hooded and Wistar rats. Physiology & Behavior 68 (2000) 521-531
21. Cuomo V., Cagiano R., De Salvia M.A., Maselli M.A., Renna G., and Racagni G. Ultrasonic vocalization in response to unavoidable aversive stimuli in rats: effects of benzodiazepines. Life Sciences 43 (1988) 485-491
22. De Araújo J.E., Huston J.P., and Brandão M.L. Aversive effects of the C-fragment of substance P in the dorsal periaqueductal gray matter. Experimental Brain Research 123 (1998) 84-89
23. De Araújo J.E., Brandão M.L., and Huston J.P. Anxiogenic effects of substance P and its 7-11 C-terminal, but not the 1-7-N-terminal, injected into the dorsal periaqueductal gray. Peptides 20 (1999) 1437-1444
24. De Araújo J.E., Huston J.P., and Brandão M.L. Opposite effects of substance P fragments C-(anxiogenic) and N-(anxiolytic) injected into dorsal periaqueductal gray. European Journal of Pharmacology 432 (2001) 43-51
25. De Araújo J.E., Huston J.P., and Brandão M.L. Place aversion induced by microinjections of C-fragment of substance P into the dorsal periaqueductal gray of rats is mediated by tachykinin NK1 receptors. Peptides 22 (2001) 1447-1452
26. Duarte F.S., Testolin R., and De Lima T.C. Further evidence on the anxiogenic-like effect of substance P evaluated in the elevated plus-maze in rats. Behavioural Brain Research 154 (2004) 501-510
27. De Luca-Vinhas M.C., Macedo C.E., and Brandão M.L. Pharmacological assessment of the freezing, antinociception, and exploratory behavior organized in the ventrolateral periaqueductal gray. Pain 121 (2006) 94-110
28. Dusterhoft F., Hausler U., and Jurgens U. Neuronal activity in the periaqueductal gray and bordering structures during vocal communication in the squirrel monkey. Neuroscience 123 (2004) 53-60
29. Fanselow M.S. The midbrain periaqueductal gray as a coordinator of action in response to fear and anxiety. In: Bandler R., and Depaulis A. (Eds). The Midbrain Periaqueductal Grey Matter: Functional, Anatomical and Immunohistochemical Organization (1991), Plenum Press, New York 151-173
30. Fanselow M.S., and Helmstetter F.J. Conditional analgesia, defensive freezing, and benzodiazepines. Behavioral Neuroscience 102 (1988) 233-243
31. Fardin V., Oliveras J.L., and Besson J.M. A reinvestigation of the analgesic effects induced by stimulation of the periaqueductal grey matter in the rat. I. The production of behavioural side effects together with analgesia. Brain Research 306 (1984) 105-123
32. Graeff F.G. Serotonin, the periaqueductal gray and panic. Neuroscience Biobehavioral Reviews 28 (2004) 239-259
33. Holstege G. Anatomical study of the final common pathway for vocalization in the cat. Journal of Comparative Neurology 284 (1989) 242-252
34. Jelen P., Soltysik S., and Zagrodzka J. 22-kHz ultrasonic vocalization in rats as an index of anxiety but not fear: behavioral and pharmacological modulation of affective state. Behavioural Brain Research 141 (2003) 63-72
35. Jenkinson K.M., Mann P.T., Southwell B.R., and Furness J.B. Independent endocytosis of the NK(1) and NK(3) tachykinin receptors in neurons of the rat myenteric plexus. Neuroscience 100 (2000) 191-199
36. Kramer M.S., Cutler N., Feighner J., Shrivastava R., Carman J., Sramek J.J., Reines S.A., Liu G., Snavely D., Wyatt-Knowles E., Hale J.J., Mills S.G., MacCoss M., Swain C.J., Harrison T., Hill R.G., Hefti F., Scolnick E.M., Cascieri M.A., Chicchi G.G., Sadowski S., Williams A.R., Hewson L., Smith D., Carlson E.J., Hargreaves R.J., and Rupniak N.M. Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science 281 (1998) 1640-1645
37. Li Y.Q., Jia H.G., Rao Z.R., and Shi J.W. Serotonin-, substance P- or leucine-enkephalin-containing neurons in the midbrain periaqueductal gray and nucleus raphe dorsalis send projection fibers to the central amygdaloid nucleus in the rat. Neuroscience Letters 120 (1990) 124-127
38. Ljungdahl A.O., Hokfelt T., and Nisson G. Distribution of substance P-like immunoreactivity in the central nervous system of the rat: I Cell bodies and nerve terminals. Neuroscience 3 (1978) 861-943
39. Lu C.-L., and Jürgens U. Effects of chemical stimulation in the periaqueductal gray on vocalization in the squirrel monkey. Brain Research Bulletin 32 (1993) 143-151
40. 1A receptor activation on the anxiogenic effects induced by isolation in the elevated plus-maze test. Physiology & Behavior 54 (1993) 753-758
41. Mamede-Rosa M.L., Nobre M.J., Oliveira A.R., and Brandão M.L. Isolation-induced changes in ultrasonic vocalization, fear-potentiated startle and prepulse inhibition in rats. Neuropsychobiology 51 (2005) 248-255
42. Mongeau R., De Oca B.M., Fanselow M.S., and Marsden C.A. Differential effects of neurokinin-1 receptor activation in subregions of the periaqueductal gray matter on conditional and unconditional fear behaviors in rats. Behavioral Neuroscience 112 (1998) 1125-1135
43. Morgan M.M., Whitney P.K., and Gold M.S. Immobility and flight associated with antinociception produced by activation of the ventral and lateral/dorsal regions of the periaqueductal gray. Brain Research 804 (1998) 159-166
44. Nobre M.J., and Brandão M.L. Analysis of freezing behavior and ultrasonic vocalization in response to foot-shocks, ultrasound signals and GABAergic inhibition in the inferior colliculus:effects of muscimol and midazolam. European Neuropsychopharmacology 14 (2004) 45-52
45. Nobre M.J., Sandner G., and Brandão M.L. Enhancement of acoustic evoked potentials and impairment of startle reflex induced by reduction of GABAergic control of the neural substrates of aversion in the inferior colliculus. Hearing Research 84 (2003) 82-90
46. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates (1997), Academic Press, Sydney
47. Pellow S., Chopin P., File S.E., and Briley M. Validation of open: closed arm entries in the elevated plus-maze as a measure of anxiety in the rat. Journal of. Neuroscience Methods 14 (1985) 149-167
48. Ranga K., and Krishnan R. Clinical experience with Substance P receptor (NK1) antagonist in depression. Journal of clinical Psychiatry 63 (2002) 25-29
49. Regoli D., Boudon A., and Fauchere J.L. Receptors and antagonists for substance P and related peptides. Pharmacological Reviews 46 (1994) 551-599
50. Santarelli, L., Gobbi, G., Debs, P.C., Sibille, E.T., Blier, P., Hen, R., Heath, M.J., 2001. Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function. In: Proceedings of the National Academy of Sciences USA. 98, 1912-1917.
51. Santos J.M., Gárgaro A.C., Oliveira A.R., Masson S., and Brandão M.L. Pharmacological dissociation of moderate and high contextual fear as assessed by freezing behavior and fear-potentiated startle. European Journal of Neuropsychopharmacology 15 (2005) 239-246
52. Sculptoreanu A., and Groat W.C. Neurokinins enhance excitability in capsaicin-responsive DRG neurons. Experimental Neurology 205 (2007) 92-100
53. Shaikh M.B., Steinberg A., and Siegel A. Evidence that substance P is utilized in medial amygdaloid facilitation of defensive rage behavior in the cat. Brain Research 625 (1993) 283-294
54. Silva R.C.B., and Brandão M.L. Acute and chronic effects of gepirone and fluoxetine in rats tested in the elevated plus-maze: An ethological analysis. Pharmacology Biochemistry & Behavior 65 (2000) 209-216
55. Tomazini F.M., Reimer A., Albrechet-Souza L., and Brandão M.L. Opposite effects of short- and long-duration isolation on ultrasonic vocalization, startle and prepulse inhibition in rats. Journal of Neuroscience Methods 153 (2006) 114-120
56. Vianna D.M.L., Landeira-Fernandez J., and Brandão M.L. Dorsolateral and ventral regions of the periaqueductal gray matter are involved in distinct types of fear. Neuroscience Biobehavioral Reviews 25 (2001) 711-719
57. Walker D.L., Cassella J.V., Lee Y., De Lima T.C., and Davis M. Opposing roles of the amygdala and dorsolateral periaqueductal gray in fear-potentiated startle. Neuroscience Biobehavioral Reviews 21 (1997) 743-753
58. Wohr M., Borta A., and Schwarting R.K. Overt behavior and ultrasonic vocalization in a fear conditioning paradigm: a dose-response study in the rat. Neurobiology of Learning & Memory 84 (2005) 228-240
59. Yajima Y., Hayashi Y., and Yoshi N. The midbrain central gray substance as a highly sensitive neural structure for the production of ultrasonic vocalization in the rat. Brain Research 198 (1980) 446-452
60. Yip J., and Chahl L.A. Distribution of Fos-like immunoreactivity in guinea-pig brain following administration of the neurokinin-1 receptor agonist, [SAR9,MET(O2)11]substance P. Neuroscience 94 (1999) 663-673
61. Yip J., and Chahl L.A. Localization of NK1 and NK3 receptors in guinea-pig brain. Regulatory Peptides 98 (2001) 55-62