Phosphorylation and translocation of heat shock protein 27 and αB-crystallin in human myocardium after cardioplegia and cardiopulmonary bypass

Journal of Thoracic and Cardiovascular Surgery

Volumn 134, Issue 6, 2007, Pages

  Clements, Richard T ^a   Sodha, Neel R ^a   Feng, Jun ^a   Mieno, Shigetoshi ^a   Boodhwani, Munir ^a   Ramlawi, Basel ^a   Bianchi, Cesario ^a   Sellke, Frank W ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHAB CRYSTALLIN; CRYSTALLIN; HEAT SHOCK PROTEIN 27; PHOSPHOSPECIFIC ANTIBODY; UNCLASSIFIED DRUG;

ARTICLE; CARDIOPLEGIA; CARDIOPULMONARY BYPASS; CONFOCAL MICROSCOPY; HEART MUSCLE; HEART RIGHT ATRIUM; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; SKELETAL MUSCLE;

EID: 36049027470     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2007.06.026     Document Type: Article

References (28)

1. Kloner R.A., and Jennings R.B. Consequences of brief ischemia: stunning, preconditioning, and their clinical implications: part 2. Circulation 104 (2001) 3158-3167
2. Kloner R.A., and Jennings R.B. Consequences of brief ischemia: stunning, preconditioning, and their clinical implications: part 1. Circulation 104 (2001) 2981-2989
3. Bolli R., and Marban E. Molecular and cellular mechanisms of myocardial stunning. Physiol Rev 79 (1999) 609-634
4. Welsh M.J., and Gaestel M. Small heat-shock protein family: function in health and disease. Ann N Y Acad Sci 851 (1998) 28-35
5. Golenhofen N., Perng M.D., Quinlan R.A., and Drenckhahn D. Comparison of the small heat shock proteins alphaB-crystallin, MKBP, HSP25, HSP20, and cvHSP in heart and skeletal muscle. Histochem Cell Biol 122 (2004) 415-425
6. Chiesi M., Longoni S., and Limbruno U. Cardiac alpha-crystallin. III. Involvement during heart ischemia. Mol Cell Biochem 97 (1990) 129-136
7. Chen Y., Rajashree R., Liu Q., and Hofmann P. Acute p38 MAPK activation decreases force development in ventricular myocytes. Am J Physiol Heart Circ Physiol 285 (2003) H2578-H2586
8. Hollander J.M., Martin J.L., Belke D.D., Scott B.T., Swanson E., Krishnamoorthy V., et al. Overexpression of wild-type heat shock protein 27 and a nonphosphorylatable heat shock protein 27 mutant protects against ischemia/reperfusion injury in a transgenic mouse model. Circulation 110 (2004) 3544-3552
9. Morrison L.E., Whittaker R.J., Klepper R.E., Wawrousek E.F., and Glembotski C.C. Roles for alphaB-crystallin and HSPB2 in protecting the myocardium from ischemia-reperfusion-induced damage in a KO mouse model. Am J Physiol Heart Circ Physiol 286 (2004) H847-H855
10. Lutsch G., Vetter R., Offhauss U., Wieske M., Grone H.J., Klemenz R., et al. Abundance and location of the small heat shock proteins HSP25 and alphaB-crystallin in rat and human heart. Circulation 96 (1997) 3466-3476
11. Sun Y., and MacRae T.H. The small heat shock proteins and their role in human disease. FEBS J 272 (2005) 2613-2627
12. Mehlen P., Hickey E., Weber L.A., and Arrigo A.P. Large unphosphorylated aggregates as the active form of hsp27 which controls intracellular reactive oxygen species and glutathione levels and generates a protection against TNFalpha in NIH-3T3-ras cells. Biochem Biophys Res Commun 241 (1997) 187-192
13. Martin J.L., Hickey E., Weber L.A., Dillmann W.H., and Mestril R. Influence of phosphorylation and oligomerization on the protective role of the small heat shock protein 27 in rat adult cardiomyocytes. Gene Expr 7 (1999) 349-355
14. Rogalla T., Ehrnsperger M., Preville X., Kotlyarov A., Lutsch G., Ducasse C., et al. Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation. J Biol Chem 274 (1999) 18947-18956
15. Morrison L.E., Hoover H.E., Thuerauf D.J., and Glembotski C.C. Mimicking phosphorylation of alphaB-crystallin on serine-59 is necessary and sufficient to provide maximal protection of cardiac myocytes from apoptosis. Circ Res 92 (2003) 203-211
16. Bennardini F., Wrzosek A., and Chiesi M. Alpha B-crystallin in cardiac tissue. Association with actin and desmin filaments. Circ Res 71 (1992) 288-294
17. Golenhofen N., Arbeiter A., Koob R., and Drenckhahn D. Ischemia-induced association of the stress protein alpha B-crystallin with I-band portion of cardiac titin. J Mol Cell Cardiol 34 (2002) 309-319
18. Golenhofen N., Ness W., Koob R., Htun P., Schaper W., and Drenckhahn D. Ischemia-induced phosphorylation and translocation of stress protein alpha B-crystallin to Z lines of myocardium. Am J Physiol 274 5 Pt 2 (1998) H1457-H1464
19. Landry J., Lambert H., Zhou M., Lavoie J.N., Hickey E., Weber L.A., et al. Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II. J Biol Chem 267 (1992) 794-803
20. Ito H., Okamoto K., Nakayama H., Isobe T., and Kato K. Phosphorylation of alpha B-crystallin in response to various types of stress. J Biol Chem 272 (1997) 29934-29941
21. Talmor D., Applebaum A., Rudich A., Shapira Y., and Tirosh A. Activation of mitogen-activated protein kinases in human heart during cardiopulmonary bypass. Circ Res 86 (2000) 1004-1007
22. Khan T.A., Bianchi C., Ruel M., Voisine P., Li J., Liddicoat J.R., et al. Mitogen-activated protein kinase inhibition and cardioplegia-cardiopulmonary bypass reduce coronary myogenic tone. Circulation 108 (2003) II-348
23. Weisel R.D. Myocardial stunning after coronary bypass surgery. J Card Surg 8 2 Suppl (1993) 242-244
24. Liao P., Wang S.Q., Wang S., Zheng M., Zheng M., Zhang S.J., et al. p38 Mitogen-activated protein kinase mediates a negative inotropic effect in cardiac myocytes. Circ Res 90 (2002) 190-196
25. Hedges J.C., Dechert M.A., Yamboliev I.A., Martin J.L., Hickey E., Weber L.A., et al. A role for p38(MAPK)/HSP27 pathway in smooth muscle cell migration. J Biol Chem 274 (1999) 24211-24219
26. Taylor R.P., and Benjamin I.J. Small heat shock proteins: a new classification scheme in mammals. J Mol Cell Cardiol 38 (2005) 433-444
27. den Engelsman J., Gerrits D., de Jong W.W., Robbins J., Kato K., and Boelens W.C. Nuclear import of {alpha}B-crystallin is phosphorylation-dependent and hampered by hyperphosphorylation of the myopathy-related mutant R120G. J Biol Chem 280 (2005) 37139-37148
28. Araujo E.G., Bianchi C., Sato K., Faro R., Li X.A., and Sellke F.W. Inactivation of the MEK/ERK pathway in the myocardium during cardiopulmonary bypass. J Thorac Cardiovasc Surg 121 (2001) 773-781