Synthesis and antitumor activity of heterocyclic acid ester derivatives of 20S-camptothecins

Chinese Chemical Letters

Volumn 18, Issue 11, 2007, Pages 1335-1338

  Li, Di Zao ^a   Li, Yan ^a   Chen, Xiao Guang ^a   Zhu, Chen Gen ^a   Yang, Jing ^a   Liu, Hong Yan ^a   Pan, Xian Dao ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Antitumor activity; Camptothecin; Heterocyclic acid; Synthesis

Indexed keywords

EID: 36049024045     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cclet.2007.09.014     Document Type: Article

References (14)

1. Lee K.H. J. Nat. Prod. 67 (2004) 273
2. Kohn K.W., and Pommier Y. Ann. N.Y. Acad. Sci. 922 (2000) 11
3. Fassberg J., and Stella V.J. J. Pharm. Sci. 81 (1992) 676
4. Zhao H., Lee C., Sai P., Choe Y.H., Boro M., Pendri A., Guan S., and Greenwald R.B. J. Org. Chem. 65 (2000) 4601
5. B.R. Vishnuvajjala, A. Garzon-Aburbeh, US Patent 4,943,579 (1990).
6. Cao Z., Harris N., Kozielski A., Vardeman D., Stehlin J.S., and Giovanella B. J. Med. Chem. 41 (1998) 31
7. Z. Cao, B.C. Giovanella, US Patent 6,228,855 (2001).
8. Bhatt R., Vries D.P., Tulinsky J., Baker B., Singer J.W., and Klein P. J. Med. Chem. 46 (2003) 90
9. Yang L.X., Pan X.D., and Wang H.J. Bioorg. Med. Chem. Lett. 12 (2002) 1241
10. Wang C.Y., Pan X.D., Liu H.Y., Fu Z.D., Wei X.Y., and Yang L.X. Bioorg. Med. Chem. 12 (2004) 3657
11. Sawada S., Nokata K., and Furuta T. Chem. Pharm. Bull. 39 (1991) 2574
12. Pan X.D., Han R., and Sun P.Y. Bioorg. Med. Chem. Lett. 13 (2003) 3739
13. Pan X.D., Liu H.Y., Sun P.Y., Zhu C.G., Yang J., Yuan K.H., and Han R. Acta Pharm. Sin. 39 (2004) 591
14. 3, δ ppm): 8.41 (s, 1H, Ar-H), 8.28 (d, 1H, J = 8.4 Hz, Ar-H), 7.94 (d, 1H, J = 7.8 Hz, Ar-H), 7.87 (t, 1H, J = 7.2 Hz, Ar-H), 7.69 (t, 1H, J = 7.5 Hz, Ar-H), 7.11 (s, 2H, Ar-H), 6.92 (m, 3H, Ar-H), 5.65, 5.41 (d, 2H, J = 17.7 Hz, 17-H), 5.27 (s, 2H, 5-H), 5.06 (t, 1H, J = 2.7 Hz, 2′-CH), 4.47 (m, 2H, ...