Regioselective synthesis and cytotoxicities of camptothecin derivatives modified at the 7-, 10- and 20-positions

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 21, 2003, Pages 3739-3741

  Pan, Xian Dao ^a   Han, Rui ^a   Sun, Piao Yang ^b  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b Hengrui Pharmaceutical Co   (China)

Author keywords

[No Author keywords available]

Indexed keywords

20 O ACYL 7 ACYLOXYMETHYLCAMPTOTHECIN; 7 ACYLOXYMETHYLCAMPTOTHECIN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN DERIVATIVE; ESTER DERIVATIVE; IRINOTECAN; TOPOTECAN; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG SYNTHESIS; ESTERIFICATION; HUMAN; HUMAN CELL; LIPOPHILICITY; LIVER CANCER; LUNG CANCER; OVARY CANCER; SQUAMOUS CELL CARCINOMA; STEREOCHEMISTRY;

EID: 0141646449     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.08.012     Document Type: Article

References (7)

1. Bailly C. Crit. Rev. Oncol. Hematol. 45:2003;91.
2. Liu L.F., Desai S.D., Li T.-K., Mao Y., Sun M., Sim S.-P. Ann. N.Y. Acad. Sci. 922:2000;1.
3. Burke T.G., Bom D. Ann. N.Y. Acad. Sci. 922:2000;36.
4. Yang L.-X., Pan X., Wang H.J. Bioorg. Med. Chem. Lett. 12:2002;1241.
5. Sawada S., Nokata K., Furuta T., Yokokura T., Miyasaki T. Chem. Pharm. Bull. 39:1991;2574.
6. Dhaon M.K., Olsen R.K., Ramasamy K. J. Org. Chem. 47:1982;1962.
7. 3); 4a. Yield 67.8%, mp 180-183 °C.