Synthesis and antitumor activity of 20-O-linked nitrogen-based camptothecin ester derivatives

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 13, 2004, Pages 3657-3662

  Wang, Cun Ying ^a   Pan, Xian Dao ^b   Liu, Hong Yan ^b   Fu, Zhao Di ^b   Wei, Xian Yong ^a   Yang, Li Xi ^c  

^a CHINA UNIVERSITY OF MINING AND TECHNOLOGY   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

^c CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

Author keywords

3 Aminopropionic acid; Antitumor activity; Camptothecin; Synthesis

Indexed keywords

3 AMIDOPROPIONATE; BETA ALANINE; CAMPTOTHECIN 20 O 3 (4 BROMO 1,8 NAPHTHALIMIDO)PROPIONATE; CAMPTOTHECIN 20 O 3 (4 PHENYL 1 PIPERAZINYL)PROPIONATE; CAMPTOTHECIN 20 O 3 (6,7 DIMETHOXY 1,2,3,4 TETRAHYDROISOQUININ 2 YL)PROPIONATE; CAMPTOTHECIN 20 O 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]PROPIONATE; CAMPTOTHECIN 20 O 3 [4 (3 METHOXYPHENYL) 1 PIPERAZINYL]PROPIONATE; CAMPTOTHECIN 20 O 3 [4 (3 TRIFLUOROMETHYLPHENYL) 1 PIPERAZINYL]PROPIONATE; CAMPTOTHECIN 20 O 3 [4 (3,4 DICHLOROPHENYL) 1 PIPERAZINYL]PROPIONATE; CAMPTOTHECIN 20 O 3 [4 (3,4 DIMETHYLPHENYL) 1 PIPERAZINYL]PROPIONATE; CAMPTOTHECIN 20 O 3 [4 (4 ACETYLPHENYL) 1 PIPERAZINYL]PROPIONATE; CAMPTOTHECIN 20 O 3 [4 (4 CHLOROPHENYL) 1 PIPERAZINYL]PROPIONATE; CAMPTOTHECIN 20 O 3 [4 (4 FLUOROPHENYL) 1 PIPERAZINYL]PROPIONATE; CAMPTOTHECIN 20 O 3 [4 (4 NITROPHENYL) 1 PIPERAZINYL]PROPIONATE; CAMPTOTHECIN 20 O 3 PHTHALIMIDOPROPIONATE; CAMPTOTHECIN DERIVATIVE; NITROGEN; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; TUMOR; TUMOR CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CELL LINE, TUMOR; ESTERS; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; LIVER NEOPLASMS; MOLECULAR STRUCTURE; NITROGEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 2942608090     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.04.023     Document Type: Article

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