Radiolabeling and in vitro and in vivo evaluation of [18F]-FE-DABP688 as a PET radioligand for the metabotropic glutamate receptor subtype 5

Nuclear Medicine and Biology

Volumn 34, Issue 8, 2007, Pages 973-980

  Honer, Michael ^a   Stoffel, Anja ^a   Kessler, Lea J ^a   Schubiger, P August ^a   Ametamey, Simon M ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

18F FE DABP688; mGluR5; quad HIDAC; Small animal PET imaging

Indexed keywords

2 METHYL 6 [(3 METHOXYPHENYL)ETHYNYL] PYRIDINE; 3 (PYRIDIN 2 LETHYNYL) CYCLOHEX 2 ENONE OXIME; FLUOROETHYL DESMETHYL ABP688 FLUORINE 18; METABOTROPIC RECEPTOR 5; OXIME DERIVATIVE; PYRIDINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; SODIUM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; BODY DISTRIBUTION; BRAIN CORTEX; BRAIN MEMBRANE; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DISSOCIATION CONSTANT; EVALUATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; ISOTOPE LABELING; LIPOPHILICITY; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; SCATCHARD PLOT; SYNTHESIS;

ANIMALS; BRAIN; ISOTOPE LABELING; MALE; METABOLIC CLEARANCE RATE; ORGAN SPECIFICITY; OXIMES; POSITRON-EMISSION TOMOGRAPHY; PYRIDINES; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; TISSUE DISTRIBUTION;

EID: 36049022739     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2007.07.017     Document Type: Article

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