Nonlinear mixed effects model analysis of the pharmacokinetics of routinely administered bepridil in Japanese patients with arrhythmias

Biological and Pharmaceutical Bulletin

Volumn 29, Issue 3, 2006, Pages 517-521

  Taguchi, Masato ^a   Fujiki, Akira ^a   Iwamoto, Jotaro ^a   Inoue, Hiroshi ^a   Tahara, Katsutoshi ^a   Saigusa, Katsuya ^a   Horiuchi, Isao ^a   Oshima, Yukari ^a   Hashimoto, Yukiya ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Aprindine; Bepridil; CYP2D6*10; Nonlinear mixed effects model; Pharmacokinetics

Indexed keywords

APRINDINE; BEPRICOR; BEPRIDIL; CYTOCHROME P450 2D6; CYTOCHROME P450 3A5;

ADULT; AGED; ALLELE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFECT; FEMALE; HEART ARRHYTHMIA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; STEADY STATE;

ADULT; AGED; ALGORITHMS; ANTI-ARRHYTHMIA AGENTS; APRINDINE; ARRHYTHMIA; BEPRIDIL; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME SYSTEM; DATA INTERPRETATION, STATISTICAL; DRUG THERAPY, COMBINATION; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; NONLINEAR DYNAMICS;

EID: 33645219122     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.29.517     Document Type: Article

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