Mucoadhesive chitosan microspheres for non-invasive and improved nasal delivery of insulin

Indian Journal of Pharmaceutical Sciences

Volumn 69, Issue 4, 2007, Pages 498-504

  Jain, S ^a   Jain, Nitin ^a   Gupta, Y ^a   Jain, A ^a   Jain, D ^a   Chaurasia, M ^a  

^a DR H S GOUR UNIVERSITY   (India)

Author keywords

Chitosan microspheres; Insulin delivery; Mucoadhesion

Indexed keywords

CHITOSAN; CITRIC ACID; GLUCOSE; GLUTARALDEHYDE; INSULIN; MICROSPHERE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; MUCOSA; NONHUMAN;

EID: 36048976867     PISSN: 0250474X     EISSN: None     Source Type: Journal    
DOI: 10.4103/0250-474X.36933     Document Type: Article

References (16)

1. Ugwoke MI, Verbeke N, Kinget R. The biopharmaceutical aspects of nasal mucoadhesive drug delivery. J Pharm Pharmacol 2001;53:3.
2. Jain SK, Chourasia MK, Jain AK, Jain RK. Development and characterization of mucoadhesive microspheres bearing salbutamol for nasal delivery. Drug Del 2004;11:113.
3. Sinha VR, Singla AK, Wadhawan S, Kaushic R, Kumria R, Bansal K, et al. Chitosan microspheres as a potential carrier for drugs. Int J Pharm 2004;274:1.
4. Thanoo BC, Sunny MC, Jayakrishnan A. Crosslinked chitosan microspheres preparation and evaluation as a matrix for the controlled release of pharmaceutics. J Pharm Pharmcol 1992;44:283.
5. Bjork E, Edman P. Degradable starch microspheres as a nasal delivery system for insulin. Int J Pharm 1988;47:233.
6. Mumtaz AH, Ching H. Design of a dissolution apparatus suitable for in situ release study of triamcinolone acetonide from bioadhesive buccal tablets. Int J Pharm 1995;121:129.
7. Takeuchi H, Yamamoto H, Niwa T, Hini T, Kawashima Y. Enteral Absorption of Insulin in Rats from Mucoadhesive Chitosan-Coated Liposomes. Pharm Res 1996;13:896.
8. Monteiro OAC, Airoldi C. Some studies of crosslinking chitosan. glutaraldehyde interaction in a homogeneous system. Int J Biol Macromol 1999;26:119.
9. Yao KD, Yin YJ, Xu MX, Wang YF. Investigation of pH-sensitive drug delivery system of chitosan/gelatin hybrid polymer network. Poly Int 1995;38:77.
10. Dumitriu S, Vidal PF, Chornet E. Hydrogels based on polysaccharides. In: Dumitriu S, editor. Polysaccharides in Medicinal Applications. Marcel Dekker: Vol. 1, New York; 1999. p. 125.
11. Berger J, Reist M, Mayer JM, Felt O, Peppas NA, Gurny R. Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications. Eur J Pharm Biopharm 2004;57(1):19.
12. Mi FL, Chen CT, Tseng YC, Kuan CY, Shyu SS. Iron(III)-carboxymethylchitin microsphere for the pH-sensitive release of 6-mercaptopurine. J Control Rel 1997;44:19.
13. Barck HP, Tirmizi SA, Risen WM. A spectroscopic and viscometric study of the metal ion-induced gelation of the biopolymer chitosan. Polymer 1997;38::2351.
14. Yalpam M, Hall LD. Some chemical and analytical aspects of polysaccharide modifications. III. Formation of branched-chain, soluble chitosan derivatives. Macromolecules 1984;17:272.
15. Shu XZ, Zhu KJ, Song W. Novel pH-sensitive citrate crosslinked chitosan film for drug controlled release. Int J Pharm 2001;212:19.
16. Langer MA, Peppas NA. Present and future applications of biomaterials in controlled drug delivery systems. Biomaterials 1981;2:201.