Clinical review: Agitation and delirium in the critically ill - Significance and management

Critical Care

Volumn 11, Issue 3, 2007, Pages

  Chevrolet, Jean Claude ^a   Jolliet, Philippe ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIARRHYTHMIC AGENT; ANTIBIOTIC AGENT; BENZODIAZEPINE DERIVATIVE; HALOPERIDOL; KETAMINE; NEUROLEPTIC AGENT; OLANZAPINE; OPIATE; PENICILLIN G; PROPOFOL; RIFAMPICIN;

AGITATION; ANTICHOLINERGIC SYNDROME; ANXIETY DISORDER; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CRITICALLY ILL PATIENT; DELIRIUM; DISEASE ASSOCIATION; DRUG CONTRAINDICATION; ELECTROENCEPHALOGRAM; EPILEPSY; EXTRAPYRAMIDAL SYMPTOM; HEART ARRHYTHMIA; HUMAN; INTENSIVE CARE; INTENSIVE CARE UNIT; LENGTH OF STAY; MENTAL DISEASE; MENTAL HEALTH; NEUROTRANSMISSION; OUTCOME ASSESSMENT; PAIN; PATIENT MONITORING; PRIORITY JOURNAL; REVIEW; CRITICAL ILLNESS; METHODOLOGY; RESTLESSNESS;

CRITICAL ILLNESS; DELIRIUM; HUMANS; INTENSIVE CARE; PSYCHOMOTOR AGITATION;

EID: 36048951164     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc5787     Document Type: Review

References (57)

1. Pandharipande P Jackson J Ely E Delirium: Acute cognitive dysfunction in the critically ill Curr Opin Crit Care 2005 11:360-368 10.1097/ 01.ccx.0000170503.76528.4b 16015117
2. Ely E Shintani A Truman B Speroff T Gordon S Harrell F Inouye S Bernard G Dittus R Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit JAMA 2004 291:1753-1762 10.1001/jama.291.14.1753 15082703
3. Siegel M Management of agitation in the intensive care unit Clin Chest Med 2003 24:713-725 10.1016/S0272-5231(03)00104-7 14710699
4. Novaes M Knobel B Bork A Pavao O Nogueira-Martins L Ferraz M Stressors in ICU: Perception of the patient, relatives and health care team Intensive Care Med 1999 25:1421-1426 10.1007/s001340051091 10660851
5. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders. 4th edition (DSM IV) Washington, DC: American Psychiatric Publishing 1994
6. Meagher D Hanlon D Mahony E Relationship between symptoms and motoric subtypes of delirium J Neuropsychiatry Clin Neurosci 2000 12:51-58 10678513
7. Cohen IL Gallagher TJ Pohlman AS Dasta JF Abraham E Papadokos PJ Management of the agitated intensive care unit patient Crit Care Med 2002 30(1):S97-S124 10.1097/00003246-200201002-00001
8. Inouye S The dilemma of delirium: Clinical and research controversies regarding diagnosis and evaluation of delirium of hospitalized elderly medical patients Am J Med 1994 97:278-288 10.1016/0002-9343(94)90011-6 8092177
9. Francis J Martin D Kapoor W A prospective study of delirium in hospitalized elderly JAMA 1990 263:1097-1101 10.1001/jama.263.8.1097 2299782
10. Bergeron N Dubois M Dumont M Dial S Skrobic Y Intensive care delirium screening checklist: Evaluation of a new screening tool Intensive Care Med 2001 27:1432-1438 10.1007/s001340100997 11511964
11. Ely E Margolin R May L Francis J May L Truman B Dittus R Speroff T Gautam S Bernard G Inouye S Evaluation of delirium in critically ill patients: Validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) Crit Care Med 2001 29:1370-1379 10.1097/ 00003246-200107000-00012 11445689
12. Inouye S Bogardus S Charpentier P Leo-Summers L Acampora D Holford T Cooney LJ A multicomponent intervention to prevent delirium in hospitalized older patients N Engl J Med 1999 340:669-676 10.1056/ NEJM199903043400901 10053175
13. Riker R Fraser G Einstein, quantum mechanics and delirium Crit Care Med 2005 33:1421-1422 15942366
14. Crippen D Life-threatening brain failure and agitation in the intensive care unit Crit Care 2000 4:81-90 11094497 10.1186/cc661 137331
15. Sharshar T Hopkinson N Orlikowski D Annane D Science review: The brain in sepsis - culprit and victim Crit Care 2005 9:37-44 1065096 15693982 10.1186/cc2951
16. Milbrandt E Angus D Potential mechanisms and markers of critical illness-associated cognitive dysfunction Curr Opin Crit Care 2005 11:355-359 10.1097/01.ccx.0000170508.63067.04 16015116
17. Hirsch L Continuous EEG monitoring in the intensive care unit: An overview J Clin Neurophysiol 2004 21:332-340 15592007
18. Flacker J Wei J Endogenous anticholinergic substances may exist during acute illness in elderly medical patients J Gerontol A Biol Sci Med Sci 2001 56:M353-M355 11382794
19. Mussi C Ferrari R Ascari S Salvioli G Importance of serum anticholinergic activity in the assessment of elderly patients with delirium J Geriatr Psychiatry Neurol 1999 12:82-86 10.1177/ 089198879901200208 10483930
20. Czura C Tracey K Autonomic neural regulation of immunity J Intern Med 2005 257:156-166 10.1111/j.1365-2796.2004.01442.x 15656874
21. Borovikova L Ivanova S Zhang M Yang H Botchkina G Watkins L Wang H Abumrad N Eaton J Tracey K Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin Nature 2000 405:458-462 10.1038/35013070 10839541
22. Sommer B Wise L Kraemer H Is dopamine administration possibly a risk factor for delirium? Crit Care Med 2002 30:1508-1511 10.1097/ 00003246-200207000-00019 12130971
23. Boyer E Shannon M The serotonin syndrome N Engl J Med 2005 352:1112-1120 10.1056/NEJMra041867 15784664
24. Pandharipande P Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients Anesthesiology 2006 104:21-26 10.1097/00000542-200601000-00005 16394685
25. Marcantonio E Juarez G Goldman L Mangione C Ludwig L Lind L Katz N Cook F Orav J Lee T The relationship of postoperative delirium with psychoactive medications JAMA 1994 272:1518-1522 10.1001/ jama.272.19.1518 7966844
26. Orlikowski D Sharshar T Annane D The brain in sepsis Adv Sepsis 2003 3:4-8
27. Jackson J The association between delirium and cognitive decline: A review of the empirical litterature Neuropsychol Rev 2004 14:87-98 10.1023/B:NERV.0000028080.39602.17 15264710
28. Jackson J Hart R Gordon S Shintani A Truman B May L Ely E Six-month neuropsychological outcome of medical intensive care unit patients Crit Care Med 2003 31:1226-1234 10.1097/01.CCM.0000059996.30263.94 12682497
29. Jones C Griffith R Humpris G Memory, delusions, and the development of of acute posttraumatic stress disorder-related symptoms after intensive care Crit Care Med 2001 29:573-580 10.1097/00003246-200103000-00019 11373423
30. Lorente L Huidoboro M Martin M Jimenez A Mora M Accidental catheter removal in critically ill patients: A prospective and observational study Crit Care 2004 8:R229-R233 522842 15312222 10.1186/cc2874
31. Thomason J Shintani A Peterson E Pun B Jackson J Ely E Intensive care unit delirium is an independent predictor of longer hospital stay: A prospective analysis of 261 non-ventilated patients Crit Care 2005 9:R375-R381 1269454 16137350 10.1186/cc3729
32. Pisani M Inouye S McNicoll L Redlich C Screening for pre-existing cognitive impairment in older intensive care patients J Am Geriatr Soc 2003 51:591-598 12752832 10.1034/j.1600-0579.2003.00201.x
33. De Jonghe B Cook D Appere-De-Vecchi C Guyatt GH Mead M Outin H Using and understanding sedation scoring systems: A systematic review Intensive Care Med 2000 26:275-285 10.1007/s001340051150 10823383
34. De Jonghe B Cook D Griffith R Appere-de-Vecchi C Guyatt GH Théron V Vagnerre V Outin H Adaptation to the intensive care environment (ATICE): Development and validation of a new sedation assessment instrument Crit Care Med 2003 31:2344-2354 10.1097/ 01.CCM.0000084850.16444.94 14501966
35. Ely E Inouye S Bernard G Gordon S Francis J May L Truman B Speroff T Gautam S Margolin R Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU) JAMA 2001 286:2703-2710 10.1001/ jama.286.21.2703 11730446
36. Devlin J Boleski G Mlynarek M Mark R Nerenz D Peterson E Jankowski M Horst H Zarowitz B Motor activity assessment scale: A valid and reliable sedation scale for use with mechanical ventilated patients in an adult surgical intensive care unit Crit Care Med 1999 27:1271-1275 10.1097/ 00003246-199907000-00008 10446819
37. Riker R Picard J Fraser G Prospective evaluation of the Sedation-Agitation Scale (SAS) for adult critically ill patients Crit Care Med 1999 27:1325-1329 10.1097/00003246-199907000-00022 10446827
38. Truman B Gordon S Peterson J Shintani A Jackson J Foss J Harding S Bernard G Dittus R Ely E Large-scale implementation of sedation and delirium monitoring in the intensive care unit: A report from two medical centers Crit Care Med 2005 33:1199-1205 10.1097/ 01.CCM.0000166867.78320.AC 15942331
39. Micek S Anand N Laible B Shannon W Kollef M Delirium as detected by the CAM-ICU predicts restraint use among mechanically ventilated patients Crit Care Med 2005 33:1260-1265 10.1097/01.CCM.0000164540.58515.BF 15942341
40. Pisani M Araujo K Van Ness P Zhang Y Ely E Inouye S A research algorithm to improve detection of delirium in the intensive care unit Crit Care 2006 10:R121-R129 1750978 16919169 10.1186/cc5027
41. Consales G de Gaudio A Sepsis assopciated encephalopathy Minerva Anestesiol 2005 71:39-52 15711505
42. Claassen J Mayer S Hirsch L Continuous EEG monitoring in patients with subarachnoid hemorrhage J Clin Neurophysiol 2005 22:92-98 10.1097/ 01.WNP.0000145006.02048.3A 15805808
43. Jordan K Continuous EEG monitoring in the neuroscience intensive care unit and emergency department J Clin Neurophysiol 1999 16:14-39 10082089 10.1097/00004691-199901000-00002
44. Chong D Hirsch L Which EEG patterns warrant treatment in the critically ill ? Reviewing the evidence for treatment of periodic epileptiform discharges and related patterns J Clin Neurophysiol 2005 22:79-91 10.1097/01.WNP.0000158699.78529.AF 15805807
45. Hirsch L Brenner R Drislane F So E Kaplan P Jordan K Herman S LaRoche S Young B Bleck T The ACNS subcommittee on research terminology for continuous EEG monitoring: Proposed standardized terminology for rythmic and periodic EEG patterns encountered in critically ill patients J Clin Neurophysiol 2005 22:128-135 10.1097/01.WNP.0000158701.89576.4C 15805813
46. Nasraway S Wu E Kelleher R Yasuda C Donnelly A How reliable is the bispectral index in critically ill patients ? A prospective, comparative, single-blinded observer study Crit Care Med 2002 30:1483-1487 10.1097/00003246-200207000-00014 12130966
47. Ely E Truman B Manzi D Sigl J Shintani A Bernard G Consciousness monitoring in ventilated patients: Bispectral EEG monitors arousal, not delirium Intensive Care Med 2004 30:1537-1543 10.1007/s00134-004-2298-1 15127189
48. Schulte-Tamburen A Scheier J Briegel J Schwender D Peter K Comparison of five sedation scoring systems by means of auditory evoked potentials Intensive Care Med 1999 25:350-352 10.1007/s001340050861 10342506
49. Zauner C Gendo A Kramer L Funk G Bauer E Schenk P Raatheiser K Madl C Impaired subcortical and cortical sensory evoked potential pathways in septic patients Crit Care Med 2002 30:1136-1139 10.1097/ 00003246-200205000-00030 12006815
50. Maccioli G Dorman T Brown B Mazuski J McLean B Kuszaij J Rosenbaum S Frankel L Devlin J Govert J Clinical practice guidelines for the maintenance of patient physical safety in intensive care unit: Use of retraining therapies - American College of Critical Care Medicine Task Force 2001-2002 Crit Care Med 2003 31:2665-2676 10.1097/ 01.CCM.0000095463.72353.AD 14605540
51. Battaglia J Pharmacological management of acute agitation Drugs 2005 65:1207-1222 10.2165/00003495-200565090-00003 15916448
52. Walder B Tramèr M Analgesia and sedation in critically ill patients Swiss Med Wkly 2004 134:333-336 15318283
53. Jacobi J Fraser G Coursin D Riker R Fontaine D Wittbrodt E Chalfin D Masica M Bjerke H Coplin W Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult, developed through the Task Froce of the American College of Critical Care Medicine (ACCM) of the Society of Critical Care Medicine (SCCM) in collaboration with the American Society of Health-System Pharmacists (ASHP), and in alliance with the American College of Chest Physicians, and approved by the Board of Regents of ACCM, and the Council of SCCM and the ASHP Board of Directors Crit Care Med 2002 30:119-141 10.1097/ 00003246-200201000-00020 11902253
54. Battaglia J Moss S Rush J Leedom L Dubin W McGlynn C Goodman L Haloperidol, lorazepam, or both for psychotic agitation ? A multicenter, prospective, double-blind, emergency department study Am J Emerg Med 1997 15:335-340 10.1016/S0735-6757(97)90119-4 9217519
55. Milbrandt E Kersten A Kong L Weissfeld L Clermont G Fink M Angus DC Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients Crit Care Med 2005 33:226-229 10.1097/ 01.CCM.0000150743.16005.9A 15644675
56. Skrobic Y Bergeron N Dumont M Gottfried S Olanzapine vs. haloperidol: treating delirium in a critical care setting Intensive Care Med 2004 30:444-449 10.1007/s00134-003-2117-0 14685663
57. Ely E The MIND Study http://www.clinicaltrials.gov/ct/gui/show/ NCT00096863;jessionid=D25B155CB67EEA3F8C98F5D6B67C9F1B?order=2