Mechanisms underlying the anti-inflammatory activity and gastric safety of acemetacin

British Journal of Pharmacology

Volumn 152, Issue 6, 2007, Pages 930-938

  Chavez Pina A E ^a,b   McKnight, W ^b   Dicay, M ^b   Castaneda Hernandez G ^a   Wallace, J L ^b  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Acemetacin; Cyclooxygenase; Gastric ulcer; Indomethacin; Inflammation; Leukocyte infiltration; Leukotriene; NSAID; Prostaglandin; Thromboxane

Indexed keywords

ACEMETACIN; INDOMETACIN; LEUKOTRIENE B4; PROSTAGLANDIN E2; THROMBOXANE B2; ZYMOSAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG SAFETY; DRUG TRANSFORMATION; IN VIVO STUDY; INFLAMMATION; LEUKOCYTE; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RAT; STOMACH INJURY;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DINOPROSTONE; EXUDATES AND TRANSUDATES; INDOMETHACIN; INFLAMMATION; INJECTIONS, SUBCUTANEOUS; LEUKOTRIENE B4; MALE; PROSTAGLANDINS; RATS; RATS, WISTAR; STOMACH ULCER; THROMBOXANES; ZYMOSAN;

EID: 36048935311     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707451     Document Type: Article

References (34)

1. Asako H, Kubes P, Wallace J, Gaginella T, Wolf RE, Granger DN (1992a). Indomethacin-induced leukocyte adhesion in mesenteric venules: role of lipoxygenase products. Am J Physiol 262: G903-G908.
2. Asako H, Kubes P, Wallace J, Wolf RE, Granger DN (1992b). Modulation of leukocyte adhesion in rat mesenteric venules by aspirin and salicylate. Gastroenterology 103: 146-152.
3. Boltze K, Brendler O, Jacobi H, Optiz W, Raddatz S, Seidel PR et al. (1980). Chemical structure and anti-inflammatory activity in the group of substituted indole-3 acetic acids. Arzneim-Forsch/Drug Res 30: 1314-1325.
4. Bori-Segura G, Torres A, Herrera LE, Olguín J (2002). Efficacy and tolerability of acemetacin, a non-steroidal anti-inflammatory drug, in Mexican patients: result of the ETAPAM study. Proc West Pharmacol Soc 45: 104-107.
5. Chou CT, Tsai YY (2002). A double-blind, randomized, controlled parallel group study evaluating the efficacy and safety of acemetacin for the management of osteoarthritis. Int J Clin Pharmacol Res 22: 1-6.
6. Edwards JW, Sedgwick AD, Willoughby DA (1981). The formulation of a structure with features of synovial lining by subcutaneous injection of air: an in vivo tissue culture system. J Pathol 134: 147-156.
7. Ferrandiz ML, Foster SJ (1991). Tumor necrosis factor production in a rat airpouch model of inflammation: role of eicosanoids. Agents Actions 32: 289-294.
8. Gilroy DW, Colville-Nash PR, Willis D, Chivers J, Paul-Clark MJ, Willoughby DA (1999). Inducible cyclooxygenase may have anti-inflammatory properties. Nat Med 5: 698-701.
9. 4 release from activated neutrophils. Proc Natl Acad Sci USA 80: 4349-4355.
10. Jacobi H, Breier P, Dell HD (1980). Anti-inflammatory action of acemetacin. Arzneim-Forsch/Drug Res 30: 1326-1347.
11. Jacobi H, Dell HD (1980). On the pharmacodynamics of acemetacin. Arzneim-Forsch/Drug Res 30: 1348-1362.
12. Jones RW, Collins AJ, Notarianni LJ, Sedman E (1991). The comparative pharmacokinetic of acemetacin in young subjects and elderly patients. Br J Clin Pharmacol 31: 543-545.
13. Kirchner T, Aparicio B, Argentieri DC, Lau CY, Ritchie DM (1997). Effects of tepoxalin, a dual inhibitor of cyclooxygenase/5-lipoxygenase, on events associated with NSAID-induced gastrointestinal inflammation. Prostaglandins Leukot Essent Fatty Acids 56: 417-423.
14. Leeb BF, Bucsi L, Keszthelyi B, Bohmova J, Valesova M, Hawel R et al. (2004). Treatment of osteoarthritis of the knee joint. Efficacy and tolerance to acemetacin slow release in comparison to celecoxib. Orthopade 33: 1032-1041.
15. Muscara MN, Vergnolle N, Lovren F, Triggle CR, Elliott SN, Asfaha S et al. (2000). Selective cyclo-oxygenase-2 inhibition with celecoxib elevates blood pressure and promotes leukocyte adherence. Br J Pharmacol 129: 1423-1430.
16. Notarianni L, Collins AJ (1987). Method for the determination of acemetacin, a non-steroidal anti-inflammatory drug, in plasma by high-performance liquid chromatography. J Chromatogr 413: 305-308.
17. Payá M, García-Pastor P, Coloma J, Alcaraz JM (1997). Nitric oxide synthase and cyclo-oxygenase pathways in the inflammatory response induced by zymosan in the rat airpouch. Br J Pharmacol 120: 1445-1452.
18. Rivera-Espinosa L, Muriel P, Ordaz-Gallo M, Perez-Urizar J, Palma-Aguirre A, Castaneda-Hernandez G (2003). Ketorolac pharmacokinetics in experimental cirrhosis by bile duct ligation in the rat. Ann Hepatol 2: 175-181.
19. 4 production during acute anaphylaxis in sheep. J Exp Med 163: 1509-1517.
20. Salmon JA, Simmons PM, Moncada S (1983). The effects of BW755C and other anti-inflammatory drugs on eicosanoid concentrations and leukocyte accumulation in experimentally-induced acute inflammation. J Pharm Pharmacol 35: 808-813.
21. Schoenfeld P, Kimmey MB, Scheiman J, Bjorkman D, Laine L (1999). Review article: nonsteroidal anti-inflammatory drug-associated gastrointestinal complications - guidelines for prevention and treatment. Aliment Pharmacol Ther 13: 1273-1285.
22. Serhan CN, Brain SD, Buckley CD, Gilroy DW, Haslett C, O'Neill LA et al. (2007). Resolution of inflammation: state of the art, definitions and terms. FASEB J 21: 325-332.
23. Tavares IA, Bennett A (1993). Acemetacin and indomethacin: differential inhibition of constitutive and inducible cyclo-oxygenases in human gastric mucosa and leucocytes. Int J Tissue Reac 15: 49-53.
24. Vaananen PM, Keenan CM, Grisham MB, Wallace JL (1992). Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy. Inflammation 16: 227-240.
25. Wallace JL (1997). Nonsteroidal anti-inflammatory drugs and gastroenteropathy: the second hundred years. Gastroenterology 112: 1000-1016.
26. Wallace JL, Arfors KE, McKnight GW (1991). A monoclonal antibody against the CD18 leukocyte adhesion molecule prevents indomethacin-induced gastric damage in the rabbit. Gastroenterology 100: 878-883.
27. Wallace JL, Bak A, McKnight W, Asfaha S, Sharkey KA, MacNaughton W (1998). Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: implications for gastrointestinal toxicity. Gastroenterology 115: 101-109.
28. Wallace JL, Caliendo G, Santagada V, Cirino G, Fiorucci S (2007). Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat. Gastroenterology 132: 261-271.
29. Wallace JL, Chapman K, McKnight W (1999). Limited anti-inflammatory efficacy of cyclo-oxygenase-2 inhibition in carrageenanairpouch inflammation. Br J Pharmacol 126: 1200-1204.
30. Wallace JL, Keenan CM, Granger DN (1990). Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process. Am J Physiol 259: G462-G467.
31. Wallace JL, McKnight W, Miyasaka M, Tamatani T, Paulson J, Anderson DC et al. (1993). Role of endothelial adhesion molecules in NSAID-induced gastric mucosal injury. Am J Physiol 265: G993-G998.
32. Wallace JL, McKnight W, Reuter BK, Vergnolle N (2000). NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2. Gastroenterology 119: 706-714.
33. Warner TD, Giuliano F, Vojnovic I, Bukasa A, Mitchell JA, Vane JR (1999). Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci USA 96: 7563-7568.
34. Zarraga IG, Schwarz ER (2007). Coxibs and heart disease: what we have learned and what else we need to know. J Am Coll Cardiol 49: 1-14.