Underestimated collateral effects of antibiotic therapy in prosthesis-associated bacterial infections

International Journal of Artificial Organs

Volumn 30, Issue 9, 2007, Pages 786-791

  Baldassarri, Lucilla ^a   Montanaro, L ^b,c   Creti, R ^a   Arciola, C R ^b,c  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Antibiotic therapy; Biomaterial associated infections; Virulence

Indexed keywords

BACTERIA; PATIENT TREATMENT;

ANTIBIOTIC THERAPY; ANTIBIOTIC TREATMENT; BACTERIAL INFECTIONS; BIOMATERIAL-ASSOCIATED INFECTION; COLLATERAL EFFECTS; HEALTHCARE PROBLEMS; MEDICAL DEVICES; VIRULENCE; VIRULENCE FACTORS;

ANTIBIOTICS;

ALPHA TOXIN; ANTIBIOTIC AGENT; AZITHROMYCIN; BIOMATERIAL; CEFAMANDOLE; CHLORAMPHENICOL; CIPROFLOXACIN; CLARITHROMYCIN; CLINDAMYCIN; DALFOPRISTIN PLUS QUINUPRISTIN; GENTAMICIN; OFLOXACIN; OXACILLIN; PENICILLIN G; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TEICOPLANIN; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; BACTERIAL INFECTION; BACTERIAL VIRULENCE; BACTERIUM ADHERENCE; BIOFILM; DRUG CHOICE; DRUG EFFICACY; ESCHERICHIA COLI O157; GENE EXPRESSION REGULATION; HUMAN; IRON METABOLISM; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; OXIDATIVE STRESS; PROSTHESIS INFECTION; REVIEW; STAPHYLOCOCCUS AUREUS;

EID: 36048930371     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.1177/039139880703000907     Document Type: Review

References (58)

1. Gristina AG, Giridhar G, Gabriel BL, Naylor PT, Myrvik QN. Cell biology and molecular mechanisms in artificial device infections. Int J Artif Organs 1993; 16: 755-63.
2. Arciola CR, An YH, Campoccia D, Donati ME, Montanaro L. Etiology of implant orthopaedic infections: a survey on 1027 clinical isolates. Int J Artif Organs 2005; 28: 1091-100.
3. Costerton JW, Montanaro L, Arciola CR. Biofilm in implant infections: its production and regulation. Int J Artif Organs 2005; 28: 1062-8.
4. Fabretti F, Huebner J. Implant infections due to enterococci: role of capsular polysaccharides and biofilm. Int J Artif Organs 2005; 28: 1079-90.
5. Obst U, Schwartz T, Volkmann H. Antibiotic resistant pathogenic bacteria and their resistance genes in bacterial biofilms. Int J Artif Organs 2005; 29: 387-94.
6. Campoccia D, Montanaro L, Baldassarri L, An YH, Arciola CR. Antibiotic resistance in Staphylococcus aureus and Staphylococcus epidermidis clinical isolates from implant orthopedic infections. Int J Artif Organs 2005; 28: 1186-91.
7. Martinez JL, Blazquez J, Baquero F. Non-canonical mechanisms of antibiotic resistance. Eur J Clin Microbiol Infect Dis 1994; 13: 1015-22.
8. McDonald PJ, Craig WA, Kunin CM. Persistent effect of antibiotics on Staphylococcus aureus after exposure for limited periods of time. J Infect Dis 1977; 135: 217-23.
9. Odenholt-Tornqvist I, Lowdin E, Cars O. Postantibiotic sub-MIC effects of vancomycin, roxithromycin, sparfloxacin and amikacin. Antimicrob Agents Chemother 1992; 36: 1852-8.
10. Weber DJ. Collateral damage and what the future might hold. The need to balance prudent antibiotic utilization and stewardship with effective patient management. Int J Infect Dis 2006; 10: 17-24.
11. Bigger JW. The bactericidal action of penicillin on Staphylococcus pyogenes: part I. Irish J Med Sci 1944; 227: 533-68.
12. Eagle H, Musselman AD. The slow recovery of bacteria from the toxic effects of penicillin. J Bacteriol 1949; 58: 475-90.
13. Parker RF, Luse S. The action of penicillin on staphylococcus: further observations on the effect of a short exposure. J Bacteriol 1948; 56: 75-81.
14. Craig WA. Pharmacokinetic/Pharmacodynamic Parameters: Rationale for Antibacterial Dosing of Mice and Men. Clin Infect Dis 1998; 26: 1-12
15. Odenholt I. Pharmacodynamic effects of subinhibitory antibiotic concentrations. Int J Antimicrob Agents 2001; 17: 1-8.
16. Schifferli DM, Beachey EH. Bacterial adhesion: modulation by antibiotics which perturb protein synthesis. Antimicrob Agents Chemother 1988; 32: 1603-8.
17. Shibl AM. Influence of subinhibitory concentrations of antibiotics on virulence of staphylococci. Rev Infect Dis 1987; 9: 704-12.
18. Sonstein SA, Burnham JC. Effect of low concentrations of quinolone antibiotics on bacterial virulence mechanisms. Diagn Microbiol Infect Dis 1993; 16: 277-89.
19. Braga PC. Effects of subinhibitory concentrations of seven macrolides and four fluoroquinolones on adhesion of Staphylococcus aureus to human mucosal cells. Chemotherapy 1994; 40: 304-10.
20. Desnottes JF, Diallo N, Loubeyre C, Moreau N. Effect of pefloxacin on microorganism: host cell interaction. J Antimicrob Chemother 1990; 26: 17-26.
21. Braga PC, Piatti G. Interference by subinhibitory concentrations of azitromycin with the mechanism of bacterial adhesion. Exper Chemother 1993; 39: 4324-37.
22. Ferrara A, Dos Santos C, Lupi A. Effect of different antibacterial agents and surfactant protein-A (SP-A) on adherence of some respiratory pathogens to bronchial epithelial cells. Int J Antimicrob Agents 2001; 17: 401-5.
23. Grimwood K, To M, Rabin HN, Woods DE. Subinhibitory antibiotics reduce Pseudomonas aeruginosa tissue injury in the rat lung model. J Antimicrob Chemother 1989; 24: 937-45.
24. Sofer D, Gilboa-Gaber N, Belz A, Garber NC. Subinhibiotry erythromycin represses production of Pseudomonas aeruginosa lectins, autoinducer and virulence factors. Chemotherapy 1999; 45: 335-41.
25. Pagano PJ, Buchanan LV, Dailey CF, Haas JV, Van Enk RA, Gibson JK. Effects of linezolid on staphylococcal adherence versus time of treatment. Int J Antimicrob Agents 2004; 23: 226-34.
26. Chisari G, Accossano S, Reibaldi M. Effect of aminoglycosides (sub-MICs) on adherence of coagulase-negative staphylococci to intraocular lens surface. J Chemother 2002; 14: 574-8.
27. Cerca N, Martins S, Pier GB, Oliveira R, Azeredo J. The relationship between inhibition of bacterial adhesion to a solid surface by sub-MICs of antibiotics and subsequent development of a biofilm. Res Microbiol 2005; 56: 650-5.
28. Hachler H. Cohen SP, Levy SB. marA, a regulated locus which controls expression of chromosomal multiple antibiotic resistance in Escherichia coli. J Bacteriol 1991; 173: 5532-8.
29. Barbosa TM, Levy SB. Differential expression of over 60 chromosomal genes in Escherichia coli by constitutive expression of MarA. J Bacteriol 2000; 182: 3467-74.
30. Kernodle DS, McGraw PA, Barg NL, Menzies BE, Voladri RKR, Harshman S. growth of Staphylococcus aureus with nafcillin in vitro induces a-toxin production and increases the lethal activity of sterile broth filtrates in a murine model. J Infect Dis 1995; 172: 410-9.
31. Azizoglou RO, Drake M. Impact of antibiotic stress on acid and heat tolerance and virulence factor expression of Escherichia coli O157:H7. J Food Prot 2007; 70: 194-9.
32. Proctor RA, Hamill RJ, Mosher DF, Textor JA, Olbrantz PJ. Effects of subinhibitory concentrations of antibiotics on Staphylococcus aureus interactions with fibronectin. J Antimicrob Chemother 1983; 12: 85-95.
33. Proctor RA, Olbrantz PJ, Mosher DF. Subinhibitory concentrations of antibiotics alter fibronectin binding to Staphylococcus aureus. Antimicrob Agents Chemother 1983; 24: 823-6.
34. Butcher WG, Close J, Krajewska-Pietrasik D, Switalski LM. Antibiotics alter interactions of Staphylococcus aureus with collagenous substrata. Chemotherapy 1994; 40: 114-23.
35. Bisognano C, Pierre EW, Lew DP, Ng EY, Hooper DC. Increased expression of fibronectin-binding proteins by fluoroquinolone-resistant Staphylococcus aureus exposed to subinhibitory levels of ciprofloxacin. Antimicrob Agents Chemother 1997; 41: 906-13.
36. Bisognano C, Vaudaux P, Rohner P, Lew DP, Hooper DC. Induction of fibronectin-binding proteins and increased adhesion of quinolone-resistant Staphylococcus aureus by subinhibitory levels of ciprofloxacin. Antimicrob Agents Chemother 2000; 44: 1428-37.
37. Costerton JW, Stewart PS, Greenber EP. Bacterial biofilms: a common cause of persistent infections. Science 1999; 284: 1318-22.
38. Henriques M, Cerca N, Azeredo J, Oliveira R. Influence of sub-inhibitory concentrations of antimicrobial agents on biofilm formation in indwelling medical devices. Int J Artif Organs 2005; 28: 1181-5.
39. Christensen GD, Simpson WA, Bisno AL, Beachey EH. Experimental foreign body infections in mice challenged with slime-producing Staphylococcus epidermidis. Infect Immun 1983; 40: 407-10.
40. Christensen GD, Baddour LM, Simpson WA. Phenotypic variation of Staphylococcus epidermidis slime production in vitro and in vivo. Infect Immun 1987; 55: 2870-7.
41. Anderl JN, Franklin MJ, Stewart PS. Role of antibiotic penetration limitation in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin. Antimicrob Agents Chemother 2000; 44: 1818-24.
42. Al-Fattani MA, Douglas LJ. Penetration of Candida biofilms by antifungal agents. Antimicrob Agents Chemother 2004; 48:3291-7.
43. Roberts ME, Stewart PS. Modeling antibiotic tolerance in biofilms by accounting for nutrient limitation. Antimicrob Agents Chemother 2004; 48: 48-52.
44. Konig C, Schwank S, Blaser J. Factors compromising antibiotic activity against biofilms of Staphylococcus epidermidis. Eur J Clin Microbiol Infect Dis 2001; 20: 20-6.
45. Zheng Z, Stewart PS. Penetration of rifampin through Staphylococcus epidermidis biofilms. Antimicrob Agents Chemother 2002; 46: 900-3.
46. Anderl JN, Zahller J, Roe F, Stewart PS. Role of nutrient limitation and stationary-phase existence in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin. Antimicrob Agents Chemother 2003; 47: 1251-6.
47. Bordello G, Werner E, Roe F, Kim AM, Ehrlich GD, Stewart PS. Oxygen limitation contributes to antibiotic tolerance of Pseudomonas aeruginosa in biofilms. Antimicrob Agents Chemother 2004; 48: 2659-64.
48. Drenkard E, Ausubel FM. Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation. Nature 2002; 416: 740-3.
49. Mah TF, Pitts B, Pellock B, Walker GC, Stewart PS, O'Toole GA. A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance. Nature 2003; 426: 306-10.
50. Whiteley M, Bangera MG, Bumgarner RE, Parsek MR, Teitzel GM, Lory S, Greenberg EP. Gene expression in Pseudomonas aeruginosa biofilms. Nature 2001; 413: 860-4.
51. El-Azizi M, Rao S, Kanchanapoom T, Khardori N. In vitro activity of vancomycin, quinupristin/dalfopristin, and linezolid against intact and disrupted biofilms of staphylococci. Ann Clin Microbiol Antimicrob 2005; 4: 2.
52. Dunne WMJ. Effects of subinhibitory concentrations of vancomycin or cefamandole on biofiim production by coagulase-negative staphylococci. Antimicrob Agents Chemother 1990; 34: 390-3.
53. Rachid S, Ohlsen K, Witte W, Hacker J, Ziebuhr W. Effect of subinhibitory antibiotic concentrations on polysaccharide intercellular adhesin expression in biofilm forming Staphylococcus epidermidis. Antimicrob Agents Chemother 2000; 44: 3357-63.
54. Di Rosa R, Basoli A, Donelli G, Penni A, Salvatori FM, Fiocca F, Baldassarri L. A microbiological and morphological study of blocked biliary stents. Microb Ecol Health Dis 1999; 11: 84-8.
55. Donelli G, Paletti C, Baldassarri L, Guaglianone E, Di Rosa R, Magi G, Spinaci C, Facinelli B. Sex-pheromone response, clumping and slime production in enterococcal strains isolated from occluded biliary stents. J Clin Microbiol 2004; 42: 3419-27.
56. Baldassarri L, Creti R, Montanaro L, Orefici L, Arciola CR. Pathogenesis of implant infections by enterococci. Int J Artif Organs 2005; 28: 1101-9.
57. Baldassarri L, Cecchini R, Bertuccini L, Ammendolia MG, Iosi F, Arciola CR, Montanaro L, Di Rosa R, Gherardi G, Dicuonzo G, Orefici G, Creti R. Enterococcus spp. produces slime and survives in rat peritoneal macrophages. Med Microbiol Immunol 2001; 190: 113-20.
58. Baldassarri L, Creti R, Recchia S, Imperi M, Facinelli B, Giovanetti E, Pataracchia M, Alfarone G, Orefici G. Therapeutic failures of macrolide-susceptible S.pyogenes inections may be due to biofilm formation. J Clin Microbiol 2006; 44: 2721-7.