Increased expression of fibronectin-binding proteins by fluoroquinolone-resistant Staphylococcus aureus exposed to subinhibitory levels of ciprofloxacin

Antimicrobial Agents and Chemotherapy

Volumn 41, Issue 5, 1997, Pages 906-913

  Bisognano, Carmelo ^a   Vaudaux, Pierre E ^a   Lew, Daniel P ^a   Ng, Eva Y W ^b   Hooper, David C ^b  

^a Faculty of Medicine   (Switzerland)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); FIBRONECTIN; PROTEIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL VIRULENCE; BACTERIUM ADHERENCE; BACTERIUM MUTANT; GENE OVEREXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAPHYLOCOCCUS AUREUS;

EID: 0031001948     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.5.906     Document Type: Article

References (62)

1. Boyce, J. M., S. M. Opal, G. Potter-Bynoe, and A. A. Medeiros. 1993. Spread of methicillin-resistant Staphylococcus aureus in a hospital after exposure to a health care worker with chronic sinusitis. Clin. Infect. Dis. 17:496-504.
2. Braga, P. C. 1994. Effects of subinhibitory concentrations of seven macrolides and four fluoroquinolones on adhesion of Staphylococcus aureus to human mucosal cells. Chemotherapy 40:304-310.
3. Butcher, W. G., J. Close, D. Krajewska-Pietrasik, and L. M. Switalski. 1994. Antibiotics alter interactions of Staphylococcus aureus with collagenous substrata. Chemotherapy 40:114-123.
4. - mutant of Staphylococcus aureus in the rabbit model of endocarditis. J. Clin. Invest. 94:1815-1822.
5. Desnottes, J. F., N. Diallo, C. Loubeyre, and N. Moreau. 1990. Effect of pefloxacin on microorganism: host cell interaction. J. Antimicrob. Chemother. 26(Suppl. B):17-26.
6. Ferrero, L., B. Cameron, and J. Crouzet. 1995. Analysis of gyrA and grlA mutations in stepwise-selected ciprofloxacin-resistant mutants of Staphylococcus aureus. Antimicrob. Agents Chemother. 39:1554-1558.
7. Ferrero, L., B. Cameron, B. Manse, D. Lagneaux, J. Crouzet, A. Famechon, and F. Blanche 1994. Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones. Mol. Microbiol. 13:641-653.
8. Flock, J. I., G. Froman, K. Jonsson, B. Guss, C. Signäs, B. Nilsson, G. Raucci, M. Höök, T. Wadström, and M. Linberg. 1987. Cloning and expression of the gene for a fibronectin-binding protein from Staphylococcus aureus. EMBO J. 6:2351-2357.
9. Foster, T. J., and D. McDevitt. 1994. Surface-associated proteins of Staphylococcus aureus: their possible roles in virulence. FEMS Microbiol. Lett. 118:199-206.
10. Foster, T. J., and D. McDevitt. 1994. Molecular basis of adherence of staphylococci to biomaterials, p. 31-44. In A. L. Bisno and F. A. Waldvogel (ed.), Infections associated with indwelling medical devices. American Society for Microbiology, Washington, D.C.
11. Greene, C., D. McDevitt, P. François, P. Vaudaux, D. P. Lew, and T. J. Foster. 1995. Adhesion properties of mutants of Staphylococcus aureus defective in fibronectin binding proteins and studies ob the expression of fnb genes. Mol. Microbiol. 17:1143-1152.
12. Greene, C., P. E. Vaudaux, P. François, R. A. Proctor, D. McDevitt, and T. J. Foster. 1996. A low-fibronectin-binding mutant of Staphylococcus aureus 879R4S has Tn918 inserted into its single fnb gene. Microbiology 142:2153-2160.
13. Hart, M. E., M. S. Smeltzer, and J. J. Iandolo. 1993. The extracellular protein regulator (xpr) affects exoprotein and agr mRNA levels in Staphylococcus aureus. J. Bacteriol. 175:7875-7879.
14. Herrmann, M., Q. J. Lai, R. M. Albrecht, D. F. Mosher, and R. A. Proctor. 1993. Adhesion of Staphylococcus aureus to surface-bound platelets: role of fibrinogen/fibrin and platelet integrins. J. Infect. Dis. 167:312-322.
15. Herrmann, M., S. J. Suchard, L. A. Boxer, F. A. Waldvogel, and D. P. Lew. 1991. Thrombospondin binds to Staphylococcus aureus and promotes staphylococcal adherence to surface. Infect. Immun. 59:279-288.
16. Herrmann, M., P. Vaudaux, D. Pittet, R. Auckenthaler, D. P. Lew, F. Schumacher-Perdreau, G. Peters, and F. A. Waldvogel. 1988. Fibronectin, fibrinogen and laminin act as mediators of adherence of clinical staphylococcal isolates to foreign material. J. Infect. Dis. 158:693-701.
17. Höök, M., L. M. Switalski, T. Wadström, and M. Lindberg. 1989. Interactions of pathogenic microorganisms with fibronectin, p. 295-308. In D. F. Mosher (ed.), Fibronectin. Academic Press, Inc., San Diego, Calif.
18. Hooper, D. C., and J. S. Wolfson. 1993. Mechanisms of bacterial resistance to quinolones, p. 97-118. In D. C. Hooper and J. S. Wolfson (ed.), Quinolone antimicrobial agents. American Society for Microbiology, Washington, D.C.
19. Ito, H., H. Yoshida, M. Bogaki-Shonai, T. Niga, H. Hattori, and S. Nakamura. 1994. Quinolone resistance mutations in the DNA gyrase gyrA and gyrB genes of Staphylococcus aureus. Antimicrob. Agents Chemother. 38: 2014-2023.
20. Jonsson, K., C. Signäs, H. P. Muller, and M. Lindberg. 1991. Two different genes encode fibronectin binding proteins in Staphylococcus aureus. The complete nucleotide sequence and characterization of the second gene. Eur. J. Biochem. 202:1041-1048.
21. Kaatz, G. W., S. M. Seo, and C. A. Ruble. 1993. Efflux-mediated fluoroquinolone resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 37:1086-1094.
22. Kernodle, D. S., P. A. McGraw, N. L. Barg, B. E. Menzies, R. K. R. Voladri, and S. Harshman. 1995. Growth of Staphylococcus aureus with nafcillin in vitro filtrates in a murine model. J. Infect. Dis. 172:410-419.
23. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-683.
24. Liang, O. D., M. Maccarana, J.-I. Flock, M. Paulsson, K. T. Preissne, and T. Wadström. 1993. Multiple interactions between human vitronectin and Staphylococcus aureus. Biochim. Biophys. Acta 1225:57-63.
25. Lindberg, M., K. Jönsson, H. P. Müller, H. Jonsson, C. Signäs, M. Höök, R. Raja, G. Raucci, and G. M. Anantharamaiah. 1990. Fibronectin-binding proteins in Staphylococcus aureus, p. 343-356. In R. P. Novick (ed.), Molecular biology of the staphylococci. VCH, New York.
26. Lopez, J. D., M. Dos Ries, and R. R. Bretani. 1985. Presence of laminin receptors in Staphylococcus aureus. Science 229:275-277.
27. McDevitt, D., P. François, P. Vaudauz, and T. J. Foster. 1994. Molecular characterization of the clumping factor (fibrinogen receptor) of Staphylococcus aureus. Mol. Microbiol. 11:237-248.
28. Muder, R. R., C. Brennen, M. M. Wagener, R. M. Vicker, J. D. Rihs, G. A. Hancock, Y. C. Yee, J. M. Miller, and V. L. Yu. 1991. Methicillin-resistant staphylococcal colonization and infection in a long-term care facility. Ann. Intern. Med. 114:107-112.
29. National Committee for Clincial Laboratory Standards. 1990. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7-A2. National Committee for Clinical Laboratory Standards, Villanova, Pa.
30. Neyfakh, A. A., C. M. Borsch, and G. W. Kaatz. 1993. Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter. Antimicrob. Agents Chemother. 37:128-129.
31. Ng, E. Y., M. Trucksis, and D. C. Hooper. 1996. Quinolone resistance mutations in topoisomerase IV: relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus. Antimicrob. Aeents Chemother. 40:1881-1888.
32. Ng, E. Y. W., M. Trucksis, and D. C. Hooper. 1994. Quinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome. Antimicrob Agents Chemother. 38:1345-1355.
33. Novick, R. P., S. J. Projan, J. Kornblum, H. F. Ross, G. Ji, B. Kreiswirth, F. Vandenesch, and S. Moghazeh. 1995. The agr P2 operon: an autocatalytic sensory transduction system in Staphylococcus aureus. Mol. Gen. Genet. 248:446-458.
34. Ohshita, Y., K. Hiramatsu, and T. Yokota. 1990. A point mutation in norA gene is responsible for quinolone resistance in Staphylococcus aureus. Biochem. Biophys. Res. Commun. 172:1028-1034.
35. Patel, A. H., P. Nowlan, E. D. Weavers, and T. J. Foster. 1987. Virulence of protein A-deficient and alpha-toxin-deficicnt mutants of Staphylococcus aureus isolated by allele-replacement. Infect. Immun. 55:3103-3110.
36. Patti, J. M., B. L. Allen, M. J. McGavin, and M. Hook. 1994. MSCRAMM-mediated adherence of microorganisms to host tissues. Annu. Rev. Microbiol. 48:585-617.
37. Patti, J. M., J. O. Boles, and M. Höök. 1993. Identification and biochemical characterization of the ligand binding domain of the collagen adhesin from Staphylococcus aureus. Biochemistry 32:11428-11435.
38. Patti, J. M., T. Bremell, D. Krajewska-Pietrasik, A. Abdelnour, A. Tarkowski, C. Rydén, and M. Höök. 1994. The Staphylococcus aureus collagen adhesin is a virulence determinant in experimental septic arthritis. Infect. Immun. 62:152-161.
39. Patti, J. M., K. House-Pompeo, J. O. Boles, N. Garza, S. Gurusiddappa, and M. Höök. 1995. Critical residues in the ligand-binding site of the Staphylococcus aureus collagen-binding adhesin (MSCRAMM). J. Biol. Chem. 270: 12005-12011.
40. Patti, J. M., H. Jonsson, B. Guss, L. M. Switalski, K. Wiberg, M. Lindberg, and M. Höök. 1992. Molecular characterization and expression of a gene encoding Staphylococcus aureus collagen adhesin. J. Biol. Chem. 267:4766-4772.
41. Peterson, L. R., K. E. Willard, L. M. Sinn, C. E. Fasching, and D. N. Gerding. 1993. gyrA sequence analysis of Staphylococcus aureus and methicillin-resistant S. aureus strains selected, in vitro, for high-level ciprofloxacin resistance. Diagn. Microbiol. Infect. Dis. 17:97-101.
42. Proctor, R. A., R. J. Hamill, D. F. Mosher, J. A. Textor, and P. J. Olbrantz. 1983. Effects of subinhibitory concentrations of antibiotics on Staphylococcus aureus interactions with fibronectin. J. Antimicrob. Chemother. 12(Suppl. C):85-95.
43. Proctor, R. A., P. J. Olbrantz, and D. F. Mosher. 1983. Subinhibitory concentrations of antibiotics alter fibronectin binding to Staphylococcus aureus. Antimicrob. Agents Chemother. 24:823-826.
44. Sanford, M. D., A. F. Widmer, M. J. Bale, R. N. Jones, and R. P. Wenzel. 1994. Efficient detection and long-term persistence of the carriage of methicillin-resistant Staphylococcus aureus. Clin. Infect. Dis. 19:1123-1128.
45. Schifferli, D. M., and E. H. Beachey. 1988. Bacterial adhesion: modulation by antibiotics which perturb protein synthesis. Antimicrob. Agents Chemother: 32:1603-1608.
46. Shibl, A. M. 1987. Influence of subinhibitory concentrations of antibiotics on virulene of staphylococci. Rev. Infect. Dis. 9:704-712.
47. Sonstein, S. A., and J. C. Burnham. 1993. Effect of low concentrations of quinolone antibiotics on bacterial virulence mechanisms. Diagn. Microbiol. Infect. Dis. 16:277-289.
48. Spycher, M. O., and U. E. Nydegger. 1986. Part of the activating cross-linked immunoglobulin G is internalized by human platelets to sites not accessible for enzymatic digestion. Blood 67:12-18.
49. Stahl, M. L., and P. A. Pattee. 1983. Confirmation of protoplast fusion-derived linkages in Staphylococcus aureus by transformation with protoplast DNA J. Bacteriol. 154:406-412.
50. Tanaka, M., Y. X. Zhang, H. Ishida, T. Akasaka, K. Sato, and I. Hayakawa. 1995. Mechanisms of 4-quinolone resistance in quinolone-resistant and methicillin-resistant Staphylococcus aureus isolates from Japan and China. J. Med. Microbiol. 42:214-219.
51. Tankovic, J., J. Duval, and P. Courvalin. 1994. Construction of a gyrA plasmid for genetic characterization of fluoroquinolone-resistant Staphylococcus aureus. FEMS Immunol. Med. Microbiol. 9:35-40.
52. Trucksis, M., D. C. Hooper, and J. S. Wolfson. 1991. Emerging resistance to fluoroquinolones in staphylococci: an alert. Ann. Intern. Med. 114:424-426. (Editorial.)
53. Trucksis, M., J. S. Wolfson, and D. C. Hooper. 1991. A novel locus conferring fluoroquinolone resistance in Staphylococcus aureus. J. Bacteriol. 173: 5854-5860.
54. Vaudaux, P., D. P. Lew, and F. A. Waldvogel. 1994. Host factors predisposing to and influencing therapy of foreign body infections, p. 1-29. In A. L. Bisno and F. A. Waldvogel (ed.), Infections associated with indwelling medical devices. American Society for Microbiology, Washington, D.C.
55. Vaudaux, P., D. Pittet, A. Haeberli, E. Huggler, U. E. Nydegger, D. P. Lew, and F. A. Waldvogel. 1989. Host factors selectively increase staphylococcal adherence on inserted catheters: a role for fibronectin and fibrinogen/fibrin. J. Infect. Dis. 160:865-875.
56. Vaudaux, P., D. Pittet, A. Haeberli, P. G. Lerch, J. J. Morgenthaler, R. A. Proctor, F. A. Waldvogel, and D. P. Lew. 1993. Fibronectin is more active than fibrin or fibrinogen in promoting Staphylococcus aureus adherence to inserted intravascular catheters. J. Infect. Dis. 167:633-641.
57. Vaudaux, P., R. Suzuki, F. A. Waldvogel, J. J. Morgenthaler, and U. E. Nydegger. 1984. Foreign body infection: role of fibronectin as a ligand for the adherence of Staphylococcus aureus. J. Infect. Dis. 150:546-553.
58. Vaudaux, P., F. A. Waldvogel, J. J. Morgenthaler, and U. E. Nydegger. 1984. Adsorption of fibronectin onto polymethylmethacrylate and promotion of Staphylococcus aureus adherence. Infect. Immun. 45:768-774.
59. Vaudaux, P. E., P. François, R. A. Proctor, D. McDevitt, T. J. Foster, R. M. Albrecht, D. P. Lew, H. Wabers, and S. L. Cooper. 1995. Use of adhesion-defective mutants of Staphylocuccus aureus to define the role of specific plasma proteins in promoting bacterial adhesion to canine arteriovenous shunts. Infect. Immun. 53:585-590.
60. Woo Park, P., D. D. Roberts, L. E. Grosso, W. C. Parks, J. Rosenbloom, W. R. Abrams, and R. P. Mecham. 1991. Binding of elastin to Staphylococcus aureus. J. Biol. Chem. 266:23399-23406.
61. Yacoub, A., P. Lindahl, K. Rubin, M. Wendel, D. Heinegård, and C. Rydén. 1994. Purification of a bone sialoprotein-binding protein from Staphylococcus aureus. Eur. J. Biochem. 222:919-925.
62. Yamagishi, J. I., T. Kojima, Y. Oyamada, K. Fujimoto, H. Hattori, S. Nakamura, and M. Inoue. 1996. Alterations in the DNA topoisomerase IV grlA gene responsible for quinolone resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 40:1157-1163.